Inhibition of advanced glycation end products by aminoguanidine restores mast cell numbers and reactivity in alloxan-diabetic rats

Mast cell number and reactivity have been shown to be down-regulated under diabetic conditions. This study was undertaken in order to investigate the role of the advanced glycation end products in the reduction of mast cell number and reactivity in diabetic rats. The effect of aminoguanidine on mast...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2011-11, Vol.669 (1-3), p.143-148
Hauptverfasser:	Carvalho, Vinicius F., Florim, Luisa T., de O. Barreto, Emiliano, Torres, Rafael C., Batista, Marcelo M., Amendoeira, Fabio C., Cordeiro, Renato S.B., Martins, Marco A., e Silva, Patrícia M.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	advanced glycation end products Advanced glycation end-product Advanced glycosylation end products alloxan Animals antigens Antigens - pharmacology Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - immunology Biological and medical sciences Blood Glucose - analysis Cell Count Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - immunology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme Inhibitors - pharmacology Etiopathogenesis. Screening. Investigations. Target tissue resistance fluorescence Glycation End Products, Advanced - blood Glycation End Products, Advanced - immunology Guanidines - pharmacology histamine Insulin - blood intravenous injection Male Mast cell mast cells Mast Cells - drug effects Mast Cells - immunology Medical sciences Mesentery - immunology Peritoneal Cavity - pathology Pharmacology. Drug treatments Pleural Cavity - immunology Rats Rats, Wistar substance P Substance P - pharmacology Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!