Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach

The present study investigated the role of histamine H3 and H4 receptors in gastric mucosal defense, by the use of selective ligands. Firstly, the affinities of several histaminergic agonists for the rat histamine H3 and H4 receptors were checked in HEK 293T cells transfected with either receptor su...

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Veröffentlicht in:	European journal of pharmacology 2011-11, Vol.669 (1-3), p.121-127
Hauptverfasser:	Coruzzi, Gabriella, Adami, Maristella, Pozzoli, Cristina, de Esch, Iwan J.P., Smits, Rogier, Leurs, Rob
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Animals antagonists Binding Biological and medical sciences Gastric lesions HCl HEK293 Cells histamine Histamine Agonists - pharmacology Histamine Antagonists - pharmacology Histamine H3 receptor Histamine H4 receptor Humans Hydrochloric Acid Male Medical sciences pharmacology Pharmacology. Drug treatments Protein Binding Radioligand Assay Rats Rats, Wistar receptors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, Histamine - genetics Receptors, Histamine - metabolism Receptors, Histamine H3 - genetics Receptors, Histamine H3 - metabolism Receptors, Histamine H4 stomach Stomach Ulcer - chemically induced Stomach Ulcer - drug therapy Stomach Ulcer - metabolism Transfection
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