The clozapine metabolite N-desmethylclozapine displays variable activity in diverse functional assays at human dopamine D2 and serotonin 5-HT1A receptors

N-desmethylclozapine (NDMC or norclozapine) is the major active metabolite of the antipsychotic clozapine in humans. The activity of NDMC differs from clozapine at a number of neurotransmitter receptors, probably influencing the pharmacological effects of clozapine treatment. Here, we tested the pro...

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Veröffentlicht in:	European journal of pharmacology 2011-11, Vol.669 (1-3), p.51-58
Hauptverfasser:	Heusler, Peter, Bruins Slot, Liesbeth, Tourette, Amélie, Tardif, Stéphanie, Cussac, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Animals Antipsychotic Agents - pharmacology Antipsychotics Biological and medical sciences calcium Calcium - metabolism Cells, Cultured chimerism CHO Cells Clozapine Clozapine - analogs & derivatives Clozapine - pharmacology Cricetinae Cricetulus dopamine Dopamine Agonists - pharmacology Dopamine Antagonists - pharmacology Dopamine D2 receptor Dopamine D2 Receptor Antagonists drugs G Protein-Coupled Inwardly-Rectifying Potassium Channels - agonists G Protein-Coupled Inwardly-Rectifying Potassium Channels - antagonists & inhibitors G Protein-Coupled Inwardly-Rectifying Potassium Channels - physiology Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Humans Medical sciences metabolites mitogen-activated protein kinase Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism N-desmethylclozapine oocytes Oocytes - drug effects Oocytes - physiology Pharmacology. Drug treatments phosphorylation potassium channels Receptor, Serotonin, 5-HT1A - metabolism receptors Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - metabolism serotonin Serotonin 5-HT1 Receptor Agonists - pharmacology Serotonin 5-HT1 Receptor Antagonists - pharmacology Serotonin 5-HT1A receptor Xenopus Xenopus laevis
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