Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: Design, synthesis, structure–activity relationships, physicochemical properties and biological activity

The discovery, synthesis and structure-activity relationship (SAR) of a novel series of cannabinoid 1 (CB 1) and cannabinoid 2 (CB 2) receptor ligands are reported. Based on the aminoalkylindole class of cannabinoid receptor agonists, a biphenyl moiety was introduced as novel lipophilic indole 3-acy...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2011-10, Vol.46 (10), p.5086-5098
Hauptverfasser:	Blaazer, Antoni R., Lange, Jos H.M., van der Neut, Martina A.W., Mulder, Arie, den Boon, Femke S., Werkman, Taco R., Kruse, Chris G., Wadman, Wytse J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azaindole Biological and medical sciences Brain - drug effects Brain - metabolism Cannabinoid receptor agonist Cannabinoid Receptor Agonists CHO Cells Cricetinae Humans Indole Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Ligands Male Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Physicochemical properties Pyrrolopyridine Rats Rats, Wistar Receptor, Cannabinoid, CB2 - agonists Receptors, Cannabinoid - metabolism Structure-Activity Relationship Structure-activity relationships
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!