Serum Brain-derived Neurotrophic Factor and Antidepressant-naive Major Depression After Lung Cancer Diagnosis
Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects wer...
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| Veröffentlicht in: | Japanese journal of clinical oncology 2011-10, Vol.41 (10), p.1233-1237 |
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| container_title | Japanese journal of clinical oncology |
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| creator | Kobayakawa, Makoto Inagaki, Masatoshi Fujimori, Maiko Hamazaki, Kei Hamazaki, Tomohito Akechi, Tatsuo Tsugane, Shoichiro Nishiwaki, Yutaka Goto, Koichi Hashimoto, Kenji Yamawaki, Shigeto Uchitomi, Yosuke |
| description | Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D < 5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels. |
| doi_str_mv | 10.1093/jjco/hyr119 |
| format | Article |
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However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D < 5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels.</description><identifier>ISSN: 0368-2811</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyr119</identifier><identifier>PMID: 21926098</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Aged ; Biomarkers - blood ; Brain-Derived Neurotrophic Factor - blood ; Case-Control Studies ; Depressive Disorder, Major - blood ; Depressive Disorder, Major - diagnosis ; Female ; Humans ; Japan ; Life Change Events ; Lung Neoplasms - pathology ; Lung Neoplasms - psychology ; Male ; Matched-Pair Analysis ; Sex Factors</subject><ispartof>Japanese journal of clinical oncology, 2011-10, Vol.41 (10), p.1233-1237</ispartof><rights>The Author (2011). Published by Oxford University Press. All rights reserved 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-675355d7177bc8d6c728b59c85521f8ada9e107cca1daafe7c494165e65146fb3</citedby><cites>FETCH-LOGICAL-c380t-675355d7177bc8d6c728b59c85521f8ada9e107cca1daafe7c494165e65146fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21926098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kobayakawa, Makoto</creatorcontrib><creatorcontrib>Inagaki, Masatoshi</creatorcontrib><creatorcontrib>Fujimori, Maiko</creatorcontrib><creatorcontrib>Hamazaki, Kei</creatorcontrib><creatorcontrib>Hamazaki, Tomohito</creatorcontrib><creatorcontrib>Akechi, Tatsuo</creatorcontrib><creatorcontrib>Tsugane, Shoichiro</creatorcontrib><creatorcontrib>Nishiwaki, Yutaka</creatorcontrib><creatorcontrib>Goto, Koichi</creatorcontrib><creatorcontrib>Hashimoto, Kenji</creatorcontrib><creatorcontrib>Yamawaki, Shigeto</creatorcontrib><creatorcontrib>Uchitomi, Yosuke</creatorcontrib><title>Serum Brain-derived Neurotrophic Factor and Antidepressant-naive Major Depression After Lung Cancer Diagnosis</title><title>Japanese journal of clinical oncology</title><addtitle>Jpn J Clin Oncol</addtitle><description>Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D < 5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Case-Control Studies</subject><subject>Depressive Disorder, Major - blood</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Japan</subject><subject>Life Change Events</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - psychology</subject><subject>Male</subject><subject>Matched-Pair Analysis</subject><subject>Sex Factors</subject><issn>0368-2811</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDFPwzAQRi0EoqUwsSNPMKBQO4kdeywtBaQCAzBHju20jho72AlS_z2pUhiZ7nTf0yfdA-ASozuMeDKtKummm53HmB-BMU4piRIa42MwRgllUcwwHoGzECqEEGFpdgpGMeYxRZyNQf2ufVfDey-MjZT25lsr-Ko771rvmo2RcClk6zwUVsGZbY3SjdchCNtGVvQ0fBFVHy-Gs3EWzspWe7jq7BrOhZX9vjBibV0w4RyclGIb9MVhTsDn8uFj_hSt3h6f57NVJBOG2ohmJCFEZTjLCskUlVnMCsIlIyTGJRNKcI1RJqXASohSZzLlKaZEU9K_XxbJBNwMvY13X50ObV6bIPV2K6x2XcgZJ4wkKWM9eTuQ0rsQvC7zxpta-F2OUb7Xm-_15oPenr469HZFrdUf--uzB64HwHXNv00_CMyFuQ</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Kobayakawa, Makoto</creator><creator>Inagaki, Masatoshi</creator><creator>Fujimori, Maiko</creator><creator>Hamazaki, Kei</creator><creator>Hamazaki, Tomohito</creator><creator>Akechi, Tatsuo</creator><creator>Tsugane, Shoichiro</creator><creator>Nishiwaki, Yutaka</creator><creator>Goto, Koichi</creator><creator>Hashimoto, Kenji</creator><creator>Yamawaki, Shigeto</creator><creator>Uchitomi, Yosuke</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Serum Brain-derived Neurotrophic Factor and Antidepressant-naive Major Depression After Lung Cancer Diagnosis</title><author>Kobayakawa, Makoto ; Inagaki, Masatoshi ; Fujimori, Maiko ; Hamazaki, Kei ; Hamazaki, Tomohito ; Akechi, Tatsuo ; Tsugane, Shoichiro ; Nishiwaki, Yutaka ; Goto, Koichi ; Hashimoto, Kenji ; Yamawaki, Shigeto ; Uchitomi, Yosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-675355d7177bc8d6c728b59c85521f8ada9e107cca1daafe7c494165e65146fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>Case-Control Studies</topic><topic>Depressive Disorder, Major - blood</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Japan</topic><topic>Life Change Events</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - psychology</topic><topic>Male</topic><topic>Matched-Pair Analysis</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kobayakawa, Makoto</creatorcontrib><creatorcontrib>Inagaki, Masatoshi</creatorcontrib><creatorcontrib>Fujimori, Maiko</creatorcontrib><creatorcontrib>Hamazaki, Kei</creatorcontrib><creatorcontrib>Hamazaki, Tomohito</creatorcontrib><creatorcontrib>Akechi, Tatsuo</creatorcontrib><creatorcontrib>Tsugane, Shoichiro</creatorcontrib><creatorcontrib>Nishiwaki, Yutaka</creatorcontrib><creatorcontrib>Goto, Koichi</creatorcontrib><creatorcontrib>Hashimoto, Kenji</creatorcontrib><creatorcontrib>Yamawaki, Shigeto</creatorcontrib><creatorcontrib>Uchitomi, Yosuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kobayakawa, Makoto</au><au>Inagaki, Masatoshi</au><au>Fujimori, Maiko</au><au>Hamazaki, Kei</au><au>Hamazaki, Tomohito</au><au>Akechi, Tatsuo</au><au>Tsugane, Shoichiro</au><au>Nishiwaki, Yutaka</au><au>Goto, Koichi</au><au>Hashimoto, Kenji</au><au>Yamawaki, Shigeto</au><au>Uchitomi, Yosuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Brain-derived Neurotrophic Factor and Antidepressant-naive Major Depression After Lung Cancer Diagnosis</atitle><jtitle>Japanese journal of clinical oncology</jtitle><addtitle>Jpn J Clin Oncol</addtitle><date>2011-10</date><risdate>2011</risdate><volume>41</volume><issue>10</issue><spage>1233</spage><epage>1237</epage><pages>1233-1237</pages><issn>0368-2811</issn><eissn>1465-3621</eissn><abstract>Previous studies have reported the existence of an association between brain-derived neurotrophic factor and major depression. However, the possible role of brain-derived neurotrophic factor in the pathophysiology of major depression after cancer diagnosis has not yet been investigated. Subjects were collected using the Lung Cancer Database project. Using the cut-off scores on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D), 81 subjects with depression (HADS-D > 10) and 81 subjects without depression (HADS-D < 5) were selected. The two groups were matched for age, sex, clinical stage and performance status. The serum brain-derived neurotrophic factor levels were measured using an enzyme-linked immunosorbent assay method. The serum brain-derived neurotrophic factor levels were not statistically different between the subjects in the depression group [29.1 (13.6) ng/ml; mean (SD)] and the non-depression group [31.4 (10.6) ng/ml] (P = 0.22). In a stratified analysis by gender, however, the mean serum brain-derived neurotrophic factor level in the depression group tended to be lower than that in the non-depression group among women (n = 24 pairs, P = 0.06). Major depression after cancer diagnosis is not associated with serum brain-derived neurotrophic factor levels.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>21926098</pmid><doi>10.1093/jjco/hyr119</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biomarkers - blood Brain-Derived Neurotrophic Factor - blood Case-Control Studies Depressive Disorder, Major - blood Depressive Disorder, Major - diagnosis Female Humans Japan Life Change Events Lung Neoplasms - pathology Lung Neoplasms - psychology Male Matched-Pair Analysis Sex Factors |
| title | Serum Brain-derived Neurotrophic Factor and Antidepressant-naive Major Depression After Lung Cancer Diagnosis |
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