Resveratrol down-regulates interferon-γ-inducible inflammatory genes in macrophages: molecular mechanism via decreased STAT-1 activation

Resveratrol (trans-3,4′,5-trihydroxystilbene) is one of nonflavonoid polyphenolic phytoalexins found in various plant species, a number of which are components of human diet including grapes and red wines. Resveratrol has exerted several beneficial effects with anti-inflammation, cardioprotection an...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2011-10, Vol.22 (10), p.902-909
Hauptverfasser:	Chung, Eun Yong, Kim, Byung Hak, Hong, Jin-Tae, Lee, Chong-Kil, Ahn, Byeongwoo, Nam, Sang-Yoon, Han, Sang-Bae, Kim, Youngsoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory activity Biological and medical sciences Bone marrow Chemokine CXCL10 - genetics Chemokine CXCL10 - metabolism chemoprevention diet Down-Regulation Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology gene expression genes grapes Humans inflammation Inflammatory macrophages interferon-gamma Interferon-gamma - pharmacology Interferon-γ Janus Kinase 2 - genetics Janus Kinase 2 - metabolism macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism mechanism of action messenger RNA Mice mitogen-activated protein kinase nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Phosphorylation Phytoalexin red wines Resveratrol RNA, Messenger - metabolism STAT-1 STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Stilbenes - pharmacology transcription factors Transcription, Genetic transcriptional activation Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitaceae
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