The role of tetraspanin CD63 in antigen presentation via MHC class II

Interactions between MHC class II (MHC II)‐positive APCs and CD4+ T cells are central to adaptive immune responses. Using an Epstein–Barr virus (EBV)‐transformed B lymphoblastoid cell line (LCL) as MHC II‐positive APCs and CD4+ T‐cell clones specific for two endogenously expressed EBV antigens, we f...

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Veröffentlicht in:	European journal of immunology 2011-09, Vol.41 (9), p.2556-2561
Hauptverfasser:	Petersen, Sven H., Odintsova, Elena, Haigh, Tracey A., Rickinson, Alan B., Taylor, Graham S., Berditchevski, Fedor
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Antigen presentation Antigen Presentation - genetics Antigens Antigens, Viral - immunology Antigens, Viral - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - ultrastructure B-Lymphocytes - virology CD4 CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology CD4-Positive T-Lymphocytes - virology CD63 Cell Line, Transformed Clone Cells Epstein-Barr virus Exosomes - immunology Exosomes - metabolism Exosomes - ultrastructure Herpesvirus 4, Human - immunology Histocompatibility Antigens Class II - immunology Histocompatibility Antigens Class II - metabolism Humans Immune system Lymphocyte Activation - genetics Medical research MHC class II Microscopy, Electron RNA, Small Interfering - genetics T cell Tetraspanin 30 - genetics Tetraspanin 30 - immunology Tetraspanin 30 - metabolism
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