Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis
Objective To determine the relationship between quadriceps weakness and cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) and if this relationship is modified by patella alta. Methods The Multicenter Osteoarthritis Study is a cohort study of persons ages 50–79 years w...
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| Veröffentlicht in: | Arthritis care & research (2010) 2011-10, Vol.63 (10), p.1391-1397 |
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| creator | Stefanik, Joshua J. Guermazi, Ali Zhu, Yanyan Zumwalt, Ann C. Gross, K. Douglas Clancy, Margaret Lynch, John A. Segal, Neil A. Lewis, Cora E. Roemer, Frank W. Powers, Christopher M. Felson, David T. |
| description | Objective
To determine the relationship between quadriceps weakness and cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) and if this relationship is modified by patella alta.
Methods
The Multicenter Osteoarthritis Study is a cohort study of persons ages 50–79 years with or at risk of knee osteoarthritis. Concentric knee extensor strength was measured using an isokinetic dynamometer. Patella alta was measured using the Insall‐Salvati ratio (ISR) on the lateral radiograph, and cartilage damage and BMLs were graded on magnetic resonance imaging in the PFJ. We determined the association between quadriceps weakness with cartilage damage and BMLs in the PFJ among knees with (ISR ≥1.2) and without (ISR |
| doi_str_mv | 10.1002/acr.20528 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_894820701</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>894820701</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3928-50355a09e99a3b9435a040e657922e5de9832ac039ce06741bf43f01a6bdfab53</originalsourceid><addsrcrecordid>eNp90MtKw0AUBuBBFFtqF76AZKdCL3NNZpaleANBFAXBRThJTjCaNHEmofTtnZranc5mzjAfP5yfkFNGZ4xSPofUzjhVXB-QIWeKTWWo9OF-lq8DMnbug_ojuNbCHJMBZxHlVEdD8vbYQWaLFBsXrBE-V-jcJGigxbKEAMoWJgGsssC1tkvbzkIZ5Ah-QBfU-Q7WOVb19qt2LdZg23dbtIU7IUc5lA7Hu3tEXq6vnpe30_uHm7vl4n6aCsP1VFGhFFCDxoBIjBT-ISmGKjKco8rQaMEhpcKkSMNIsiSXIqcMwiTLIVFiRM773MbWXx26Nq4Kl24XWGHduVgbqTmNKPPy4l_JqBEyNDIynl72NLW1cxbzuLFFBXbjUbwtPvbFxz_Fe3u2i-2SCrO9_K3Zg3kP1kWJm7-T4sXyqY_8BgfAjKs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1093469479</pqid></control><display><type>article</type><title>Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Stefanik, Joshua J. ; Guermazi, Ali ; Zhu, Yanyan ; Zumwalt, Ann C. ; Gross, K. Douglas ; Clancy, Margaret ; Lynch, John A. ; Segal, Neil A. ; Lewis, Cora E. ; Roemer, Frank W. ; Powers, Christopher M. ; Felson, David T.</creator><creatorcontrib>Stefanik, Joshua J. ; Guermazi, Ali ; Zhu, Yanyan ; Zumwalt, Ann C. ; Gross, K. Douglas ; Clancy, Margaret ; Lynch, John A. ; Segal, Neil A. ; Lewis, Cora E. ; Roemer, Frank W. ; Powers, Christopher M. ; Felson, David T.</creatorcontrib><description>Objective
To determine the relationship between quadriceps weakness and cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) and if this relationship is modified by patella alta.
Methods
The Multicenter Osteoarthritis Study is a cohort study of persons ages 50–79 years with or at risk of knee osteoarthritis. Concentric knee extensor strength was measured using an isokinetic dynamometer. Patella alta was measured using the Insall‐Salvati ratio (ISR) on the lateral radiograph, and cartilage damage and BMLs were graded on magnetic resonance imaging in the PFJ. We determined the association between quadriceps weakness with cartilage damage and BMLs in the PFJ among knees with (ISR ≥1.2) and without (ISR <1.2) patella alta using multiple binomial regression.
Results
A total of 807 knees were studied (mean age 62 years, body mass index 30 kg/m2, ISR 1.10) and 64% were from women. Compared with the knees in the highest strength tertile, those in the lowest had 10.2% (95% confidence interval [95% CI] 3, 18), 9.1% (95% CI 2, 16), and 7.1% (95% CI 1, 13) higher prevalence of lateral PFJ cartilage damage, medial PFJ cartilage damage, and lateral PFJ BMLs, respectively. The association between quadriceps weakness with cartilage damage and BMLs was not different between knees with and without patella alta in the lateral PFJ.
Conclusion
Quadriceps weakness was associated with PFJ cartilage damage and BMLs. While both patella alta and quadriceps weakness were associated with PFJ damage, the combination of the two was not associated with more damage than either of these factors alone.</description><identifier>ISSN: 2151-464X</identifier><identifier>ISSN: 2151-4658</identifier><identifier>EISSN: 2151-4658</identifier><identifier>DOI: 10.1002/acr.20528</identifier><identifier>PMID: 21702087</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Age ; Aged ; Alabama ; Body mass index ; Bone marrow ; Cartilage diseases ; Cartilage, Articular - pathology ; Female ; Humans ; Iowa ; Joint diseases ; Knee ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Muscle Strength ; Muscle Strength Dynamometer ; Muscle Weakness - etiology ; Muscle Weakness - pathology ; Muscle Weakness - physiopathology ; Osteoarthritis ; Osteoarthritis, Knee - complications ; Osteoarthritis, Knee - pathology ; Osteoarthritis, Knee - physiopathology ; Patella ; Patella - diagnostic imaging ; Patella - pathology ; Patellofemoral Joint - pathology ; quadriceps muscle ; Quadriceps Muscle - physiopathology ; Radiography ; Regression Analysis ; Risk Assessment ; Risk Factors</subject><ispartof>Arthritis care & research (2010), 2011-10, Vol.63 (10), p.1391-1397</ispartof><rights>Copyright © 2011 by the American College of Rheumatology</rights><rights>Copyright © 2011 by the American College of Rheumatology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3928-50355a09e99a3b9435a040e657922e5de9832ac039ce06741bf43f01a6bdfab53</citedby><cites>FETCH-LOGICAL-c3928-50355a09e99a3b9435a040e657922e5de9832ac039ce06741bf43f01a6bdfab53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Facr.20528$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Facr.20528$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21702087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stefanik, Joshua J.</creatorcontrib><creatorcontrib>Guermazi, Ali</creatorcontrib><creatorcontrib>Zhu, Yanyan</creatorcontrib><creatorcontrib>Zumwalt, Ann C.</creatorcontrib><creatorcontrib>Gross, K. Douglas</creatorcontrib><creatorcontrib>Clancy, Margaret</creatorcontrib><creatorcontrib>Lynch, John A.</creatorcontrib><creatorcontrib>Segal, Neil A.</creatorcontrib><creatorcontrib>Lewis, Cora E.</creatorcontrib><creatorcontrib>Roemer, Frank W.</creatorcontrib><creatorcontrib>Powers, Christopher M.</creatorcontrib><creatorcontrib>Felson, David T.</creatorcontrib><title>Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis</title><title>Arthritis care & research (2010)</title><addtitle>Arthritis Care Res (Hoboken)</addtitle><description>Objective
To determine the relationship between quadriceps weakness and cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) and if this relationship is modified by patella alta.
Methods
The Multicenter Osteoarthritis Study is a cohort study of persons ages 50–79 years with or at risk of knee osteoarthritis. Concentric knee extensor strength was measured using an isokinetic dynamometer. Patella alta was measured using the Insall‐Salvati ratio (ISR) on the lateral radiograph, and cartilage damage and BMLs were graded on magnetic resonance imaging in the PFJ. We determined the association between quadriceps weakness with cartilage damage and BMLs in the PFJ among knees with (ISR ≥1.2) and without (ISR <1.2) patella alta using multiple binomial regression.
Results
A total of 807 knees were studied (mean age 62 years, body mass index 30 kg/m2, ISR 1.10) and 64% were from women. Compared with the knees in the highest strength tertile, those in the lowest had 10.2% (95% confidence interval [95% CI] 3, 18), 9.1% (95% CI 2, 16), and 7.1% (95% CI 1, 13) higher prevalence of lateral PFJ cartilage damage, medial PFJ cartilage damage, and lateral PFJ BMLs, respectively. The association between quadriceps weakness with cartilage damage and BMLs was not different between knees with and without patella alta in the lateral PFJ.
Conclusion
Quadriceps weakness was associated with PFJ cartilage damage and BMLs. While both patella alta and quadriceps weakness were associated with PFJ damage, the combination of the two was not associated with more damage than either of these factors alone.</description><subject>Age</subject><subject>Aged</subject><subject>Alabama</subject><subject>Body mass index</subject><subject>Bone marrow</subject><subject>Cartilage diseases</subject><subject>Cartilage, Articular - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Iowa</subject><subject>Joint diseases</subject><subject>Knee</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Muscle Strength</subject><subject>Muscle Strength Dynamometer</subject><subject>Muscle Weakness - etiology</subject><subject>Muscle Weakness - pathology</subject><subject>Muscle Weakness - physiopathology</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - complications</subject><subject>Osteoarthritis, Knee - pathology</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Patella</subject><subject>Patella - diagnostic imaging</subject><subject>Patella - pathology</subject><subject>Patellofemoral Joint - pathology</subject><subject>quadriceps muscle</subject><subject>Quadriceps Muscle - physiopathology</subject><subject>Radiography</subject><subject>Regression Analysis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>2151-464X</issn><issn>2151-4658</issn><issn>2151-4658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MtKw0AUBuBBFFtqF76AZKdCL3NNZpaleANBFAXBRThJTjCaNHEmofTtnZranc5mzjAfP5yfkFNGZ4xSPofUzjhVXB-QIWeKTWWo9OF-lq8DMnbug_ojuNbCHJMBZxHlVEdD8vbYQWaLFBsXrBE-V-jcJGigxbKEAMoWJgGsssC1tkvbzkIZ5Ah-QBfU-Q7WOVb19qt2LdZg23dbtIU7IUc5lA7Hu3tEXq6vnpe30_uHm7vl4n6aCsP1VFGhFFCDxoBIjBT-ISmGKjKco8rQaMEhpcKkSMNIsiSXIqcMwiTLIVFiRM773MbWXx26Nq4Kl24XWGHduVgbqTmNKPPy4l_JqBEyNDIynl72NLW1cxbzuLFFBXbjUbwtPvbFxz_Fe3u2i-2SCrO9_K3Zg3kP1kWJm7-T4sXyqY_8BgfAjKs</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Stefanik, Joshua J.</creator><creator>Guermazi, Ali</creator><creator>Zhu, Yanyan</creator><creator>Zumwalt, Ann C.</creator><creator>Gross, K. Douglas</creator><creator>Clancy, Margaret</creator><creator>Lynch, John A.</creator><creator>Segal, Neil A.</creator><creator>Lewis, Cora E.</creator><creator>Roemer, Frank W.</creator><creator>Powers, Christopher M.</creator><creator>Felson, David T.</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis</title><author>Stefanik, Joshua J. ; Guermazi, Ali ; Zhu, Yanyan ; Zumwalt, Ann C. ; Gross, K. Douglas ; Clancy, Margaret ; Lynch, John A. ; Segal, Neil A. ; Lewis, Cora E. ; Roemer, Frank W. ; Powers, Christopher M. ; Felson, David T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3928-50355a09e99a3b9435a040e657922e5de9832ac039ce06741bf43f01a6bdfab53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Age</topic><topic>Aged</topic><topic>Alabama</topic><topic>Body mass index</topic><topic>Bone marrow</topic><topic>Cartilage diseases</topic><topic>Cartilage, Articular - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Iowa</topic><topic>Joint diseases</topic><topic>Knee</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Muscle Strength</topic><topic>Muscle Strength Dynamometer</topic><topic>Muscle Weakness - etiology</topic><topic>Muscle Weakness - pathology</topic><topic>Muscle Weakness - physiopathology</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Knee - complications</topic><topic>Osteoarthritis, Knee - pathology</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>Patella</topic><topic>Patella - diagnostic imaging</topic><topic>Patella - pathology</topic><topic>Patellofemoral Joint - pathology</topic><topic>quadriceps muscle</topic><topic>Quadriceps Muscle - physiopathology</topic><topic>Radiography</topic><topic>Regression Analysis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stefanik, Joshua J.</creatorcontrib><creatorcontrib>Guermazi, Ali</creatorcontrib><creatorcontrib>Zhu, Yanyan</creatorcontrib><creatorcontrib>Zumwalt, Ann C.</creatorcontrib><creatorcontrib>Gross, K. Douglas</creatorcontrib><creatorcontrib>Clancy, Margaret</creatorcontrib><creatorcontrib>Lynch, John A.</creatorcontrib><creatorcontrib>Segal, Neil A.</creatorcontrib><creatorcontrib>Lewis, Cora E.</creatorcontrib><creatorcontrib>Roemer, Frank W.</creatorcontrib><creatorcontrib>Powers, Christopher M.</creatorcontrib><creatorcontrib>Felson, David T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis care & research (2010)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stefanik, Joshua J.</au><au>Guermazi, Ali</au><au>Zhu, Yanyan</au><au>Zumwalt, Ann C.</au><au>Gross, K. Douglas</au><au>Clancy, Margaret</au><au>Lynch, John A.</au><au>Segal, Neil A.</au><au>Lewis, Cora E.</au><au>Roemer, Frank W.</au><au>Powers, Christopher M.</au><au>Felson, David T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis</atitle><jtitle>Arthritis care & research (2010)</jtitle><addtitle>Arthritis Care Res (Hoboken)</addtitle><date>2011-10</date><risdate>2011</risdate><volume>63</volume><issue>10</issue><spage>1391</spage><epage>1397</epage><pages>1391-1397</pages><issn>2151-464X</issn><issn>2151-4658</issn><eissn>2151-4658</eissn><abstract>Objective
To determine the relationship between quadriceps weakness and cartilage damage and bone marrow lesions (BMLs) in the patellofemoral joint (PFJ) and if this relationship is modified by patella alta.
Methods
The Multicenter Osteoarthritis Study is a cohort study of persons ages 50–79 years with or at risk of knee osteoarthritis. Concentric knee extensor strength was measured using an isokinetic dynamometer. Patella alta was measured using the Insall‐Salvati ratio (ISR) on the lateral radiograph, and cartilage damage and BMLs were graded on magnetic resonance imaging in the PFJ. We determined the association between quadriceps weakness with cartilage damage and BMLs in the PFJ among knees with (ISR ≥1.2) and without (ISR <1.2) patella alta using multiple binomial regression.
Results
A total of 807 knees were studied (mean age 62 years, body mass index 30 kg/m2, ISR 1.10) and 64% were from women. Compared with the knees in the highest strength tertile, those in the lowest had 10.2% (95% confidence interval [95% CI] 3, 18), 9.1% (95% CI 2, 16), and 7.1% (95% CI 1, 13) higher prevalence of lateral PFJ cartilage damage, medial PFJ cartilage damage, and lateral PFJ BMLs, respectively. The association between quadriceps weakness with cartilage damage and BMLs was not different between knees with and without patella alta in the lateral PFJ.
Conclusion
Quadriceps weakness was associated with PFJ cartilage damage and BMLs. While both patella alta and quadriceps weakness were associated with PFJ damage, the combination of the two was not associated with more damage than either of these factors alone.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>21702087</pmid><doi>10.1002/acr.20528</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2151-464X |
| ispartof | Arthritis care & research (2010), 2011-10, Vol.63 (10), p.1391-1397 |
| issn | 2151-464X 2151-4658 2151-4658 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Age Aged Alabama Body mass index Bone marrow Cartilage diseases Cartilage, Articular - pathology Female Humans Iowa Joint diseases Knee Magnetic Resonance Imaging Male Middle Aged Muscle Strength Muscle Strength Dynamometer Muscle Weakness - etiology Muscle Weakness - pathology Muscle Weakness - physiopathology Osteoarthritis Osteoarthritis, Knee - complications Osteoarthritis, Knee - pathology Osteoarthritis, Knee - physiopathology Patella Patella - diagnostic imaging Patella - pathology Patellofemoral Joint - pathology quadriceps muscle Quadriceps Muscle - physiopathology Radiography Regression Analysis Risk Assessment Risk Factors |
| title | Quadriceps weakness, patella alta, and structural features of patellofemoral osteoarthritis |
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