Analysis of eIF4E and 4EBP1 mRNAs in head and neck cancer
Objectives/Hypothesis: The eukaryotic translation initiation factor 4E (eIF4E) in conjunction with its binding protein, 4EBP1, regulates the translation of cap‐dependent mRNAs. An aberrant increase in eIF4E shifts the balance in favor of translation of transcripts that promote cell proliferation and...
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| Veröffentlicht in: | The Laryngoscope 2011-10, Vol.121 (10), p.2136-2141 |
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| creator | Sunavala-Dossabhoy, Gulshan Palaniyandi, Senthilnathan Clark, Cheryl Nathan, Cherie-Ann O. Abreo, Fleurette W. Caldito, Gloria |
| description | Objectives/Hypothesis:
The eukaryotic translation initiation factor 4E (eIF4E) in conjunction with its binding protein, 4EBP1, regulates the translation of cap‐dependent mRNAs. An aberrant increase in eIF4E shifts the balance in favor of translation of transcripts that promote cell proliferation and malignancy. eIF4E protein is commonly elevated in head and neck squamous cell carcinomas (HNSCC), and its overexpression is associated with increased recurrence. An underlying mechanism for eIF4E overexpression is gene amplification, and we wanted to determine whether eIF4E mRNA could serve as a prognostic maker of HNSCC.
Methods:
Tumor specimens from 26 HNSCC patients and oral tissues from 17 control subjects were examined for eIF4E and 4EBP1 by semiquantitative RT‐PCR and correlated with clinical and pathologic findings.
Results:
Unlike eIF4E mRNA alone, expression of eIF4E relative to 4EBP1 was a more precise predictor of HNSCC and its progression (P < .01, Wilcoxon rank sum test). Eight of 26 patients (31%) had elevated eIF4E:4EBP1 (4E:4EBP1; >25), and 7 of these (87.5%) had recurrence. Alternately, from 18 patients with low 4E:4EBP1 ( |
| doi_str_mv | 10.1002/lary.22144 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_894817155</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>894817155</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3964-959b6254beb9b9d12bfc4b66e640e1103128babab59aae915e0254f2b19c730a3</originalsourceid><addsrcrecordid>eNp9kE1Lw0AQhhdRtFYv_gDJRQQhdWc_kuyxllYrRUtR1NOyu5lgNElr1qL996Yf1pvsYWDnmXeYh5AToB2glF0Wpl50GAMhdkgLJIdQKCV3Satp8jCR7PmAHHr_RinEXNJ9csAgUYngvEVUtzLFwuc-mGYBDgeiH5gqDUT_agxBObnr-iCvglc06eq_QvceOFM5rI_IXmYKj8eb2iaPg_5D7yYc3V8Pe91R6LiKRKikshGTwqJVVqXAbOaEjSKMBEUAyoEl1jRPKmNQgUTa0BmzoFzMqeFtcr7OndXTjzn6T13m3mFRmAqnc68TJRKIQcqGvFiTrp56X2OmZ3VeNnI0UL00pZem9MpUA59uYue2xHSL_qppgLMNYLwzRVY3V-f-jxMRjSFZBsGa-8oLXPyzUo-6k5ff5eF6Jvef-L2dMfW7jmIeS_10d60nqjd4GN_2tOQ_5lOMBg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>894817155</pqid></control><display><type>article</type><title>Analysis of eIF4E and 4EBP1 mRNAs in head and neck cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Sunavala-Dossabhoy, Gulshan ; Palaniyandi, Senthilnathan ; Clark, Cheryl ; Nathan, Cherie-Ann O. ; Abreo, Fleurette W. ; Caldito, Gloria</creator><creatorcontrib>Sunavala-Dossabhoy, Gulshan ; Palaniyandi, Senthilnathan ; Clark, Cheryl ; Nathan, Cherie-Ann O. ; Abreo, Fleurette W. ; Caldito, Gloria</creatorcontrib><description>Objectives/Hypothesis:
The eukaryotic translation initiation factor 4E (eIF4E) in conjunction with its binding protein, 4EBP1, regulates the translation of cap‐dependent mRNAs. An aberrant increase in eIF4E shifts the balance in favor of translation of transcripts that promote cell proliferation and malignancy. eIF4E protein is commonly elevated in head and neck squamous cell carcinomas (HNSCC), and its overexpression is associated with increased recurrence. An underlying mechanism for eIF4E overexpression is gene amplification, and we wanted to determine whether eIF4E mRNA could serve as a prognostic maker of HNSCC.
Methods:
Tumor specimens from 26 HNSCC patients and oral tissues from 17 control subjects were examined for eIF4E and 4EBP1 by semiquantitative RT‐PCR and correlated with clinical and pathologic findings.
Results:
Unlike eIF4E mRNA alone, expression of eIF4E relative to 4EBP1 was a more precise predictor of HNSCC and its progression (P < .01, Wilcoxon rank sum test). Eight of 26 patients (31%) had elevated eIF4E:4EBP1 (4E:4EBP1; >25), and 7 of these (87.5%) had recurrence. Alternately, from 18 patients with low 4E:4EBP1 (<25; 69%), only 5 patients had recurrence (30.1%). To determine the probability of no recurrence, Kaplan–Meier analysis showed significantly poor disease‐free survival in patients with elevated 4E:4EBP1 than those with low ratios (P < .01, log rank test).
Conclusions:
Elevated 4E:4EBP1 significantly correlated with increased disease recurrence. Because 4EBP1 modulates eIF4E activity, our results highlight the importance of incorporating a joint analysis of eIF4E and 4EBP1 mRNAs in HNSCC patient care decisions.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.22144</identifier><identifier>PMID: 21898433</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>4EBP1 ; Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Adult ; Aged ; Biological and medical sciences ; biomarker ; Biomarkers, Tumor - metabolism ; Biopsy, Needle ; Carcinoma - genetics ; Carcinoma - mortality ; Carcinoma - pathology ; Carcinoma, Squamous Cell ; Chi-Square Distribution ; Cohort Studies ; Disease Progression ; eIF4E ; Eukaryotic Initiation Factor-4E - genetics ; Eukaryotic Initiation Factor-4E - metabolism ; Female ; head and neck cancer ; Head and Neck Neoplasms - genetics ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Humans ; Level 2b ; Level of Evidence: Prognosis Study ; Level of Evidence: Prognosis Study, Level 2b ; Male ; Medical sciences ; Middle Aged ; Neoplasm Invasiveness - pathology ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - metabolism ; Neoplasm Staging ; Neoplasms, Squamous Cell - genetics ; Neoplasms, Squamous Cell - mortality ; Neoplasms, Squamous Cell - pathology ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Predictive Value of Tests ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction ; Risk Assessment ; RNA, Messenger - analysis ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; Sensitivity and Specificity ; Squamous Cell Carcinoma of Head and Neck ; Statistics, Nonparametric ; Survival Analysis ; Tissue Culture Techniques ; Tumors</subject><ispartof>The Laryngoscope, 2011-10, Vol.121 (10), p.2136-2141</ispartof><rights>Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3964-959b6254beb9b9d12bfc4b66e640e1103128babab59aae915e0254f2b19c730a3</citedby><cites>FETCH-LOGICAL-c3964-959b6254beb9b9d12bfc4b66e640e1103128babab59aae915e0254f2b19c730a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.22144$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.22144$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24607184$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21898433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sunavala-Dossabhoy, Gulshan</creatorcontrib><creatorcontrib>Palaniyandi, Senthilnathan</creatorcontrib><creatorcontrib>Clark, Cheryl</creatorcontrib><creatorcontrib>Nathan, Cherie-Ann O.</creatorcontrib><creatorcontrib>Abreo, Fleurette W.</creatorcontrib><creatorcontrib>Caldito, Gloria</creatorcontrib><title>Analysis of eIF4E and 4EBP1 mRNAs in head and neck cancer</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis:
The eukaryotic translation initiation factor 4E (eIF4E) in conjunction with its binding protein, 4EBP1, regulates the translation of cap‐dependent mRNAs. An aberrant increase in eIF4E shifts the balance in favor of translation of transcripts that promote cell proliferation and malignancy. eIF4E protein is commonly elevated in head and neck squamous cell carcinomas (HNSCC), and its overexpression is associated with increased recurrence. An underlying mechanism for eIF4E overexpression is gene amplification, and we wanted to determine whether eIF4E mRNA could serve as a prognostic maker of HNSCC.
Methods:
Tumor specimens from 26 HNSCC patients and oral tissues from 17 control subjects were examined for eIF4E and 4EBP1 by semiquantitative RT‐PCR and correlated with clinical and pathologic findings.
Results:
Unlike eIF4E mRNA alone, expression of eIF4E relative to 4EBP1 was a more precise predictor of HNSCC and its progression (P < .01, Wilcoxon rank sum test). Eight of 26 patients (31%) had elevated eIF4E:4EBP1 (4E:4EBP1; >25), and 7 of these (87.5%) had recurrence. Alternately, from 18 patients with low 4E:4EBP1 (<25; 69%), only 5 patients had recurrence (30.1%). To determine the probability of no recurrence, Kaplan–Meier analysis showed significantly poor disease‐free survival in patients with elevated 4E:4EBP1 than those with low ratios (P < .01, log rank test).
Conclusions:
Elevated 4E:4EBP1 significantly correlated with increased disease recurrence. Because 4EBP1 modulates eIF4E activity, our results highlight the importance of incorporating a joint analysis of eIF4E and 4EBP1 mRNAs in HNSCC patient care decisions.</description><subject>4EBP1</subject><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>biomarker</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biopsy, Needle</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma, Squamous Cell</subject><subject>Chi-Square Distribution</subject><subject>Cohort Studies</subject><subject>Disease Progression</subject><subject>eIF4E</subject><subject>Eukaryotic Initiation Factor-4E - genetics</subject><subject>Eukaryotic Initiation Factor-4E - metabolism</subject><subject>Female</subject><subject>head and neck cancer</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Humans</subject><subject>Level 2b</subject><subject>Level of Evidence: Prognosis Study</subject><subject>Level of Evidence: Prognosis Study, Level 2b</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - metabolism</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Squamous Cell - genetics</subject><subject>Neoplasms, Squamous Cell - mortality</subject><subject>Neoplasms, Squamous Cell - pathology</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Risk Assessment</subject><subject>RNA, Messenger - analysis</subject><subject>RNA-Binding Proteins - genetics</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>Sensitivity and Specificity</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>Statistics, Nonparametric</subject><subject>Survival Analysis</subject><subject>Tissue Culture Techniques</subject><subject>Tumors</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRtFYv_gDJRQQhdWc_kuyxllYrRUtR1NOyu5lgNElr1qL996Yf1pvsYWDnmXeYh5AToB2glF0Wpl50GAMhdkgLJIdQKCV3Satp8jCR7PmAHHr_RinEXNJ9csAgUYngvEVUtzLFwuc-mGYBDgeiH5gqDUT_agxBObnr-iCvglc06eq_QvceOFM5rI_IXmYKj8eb2iaPg_5D7yYc3V8Pe91R6LiKRKikshGTwqJVVqXAbOaEjSKMBEUAyoEl1jRPKmNQgUTa0BmzoFzMqeFtcr7OndXTjzn6T13m3mFRmAqnc68TJRKIQcqGvFiTrp56X2OmZ3VeNnI0UL00pZem9MpUA59uYue2xHSL_qppgLMNYLwzRVY3V-f-jxMRjSFZBsGa-8oLXPyzUo-6k5ff5eF6Jvef-L2dMfW7jmIeS_10d60nqjd4GN_2tOQ_5lOMBg</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Sunavala-Dossabhoy, Gulshan</creator><creator>Palaniyandi, Senthilnathan</creator><creator>Clark, Cheryl</creator><creator>Nathan, Cherie-Ann O.</creator><creator>Abreo, Fleurette W.</creator><creator>Caldito, Gloria</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Analysis of eIF4E and 4EBP1 mRNAs in head and neck cancer</title><author>Sunavala-Dossabhoy, Gulshan ; Palaniyandi, Senthilnathan ; Clark, Cheryl ; Nathan, Cherie-Ann O. ; Abreo, Fleurette W. ; Caldito, Gloria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3964-959b6254beb9b9d12bfc4b66e640e1103128babab59aae915e0254f2b19c730a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>4EBP1</topic><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Adaptor Proteins, Signal Transducing - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>biomarker</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biopsy, Needle</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma, Squamous Cell</topic><topic>Chi-Square Distribution</topic><topic>Cohort Studies</topic><topic>Disease Progression</topic><topic>eIF4E</topic><topic>Eukaryotic Initiation Factor-4E - genetics</topic><topic>Eukaryotic Initiation Factor-4E - metabolism</topic><topic>Female</topic><topic>head and neck cancer</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Humans</topic><topic>Level 2b</topic><topic>Level of Evidence: Prognosis Study</topic><topic>Level of Evidence: Prognosis Study, Level 2b</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - metabolism</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Squamous Cell - genetics</topic><topic>Neoplasms, Squamous Cell - mortality</topic><topic>Neoplasms, Squamous Cell - pathology</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Risk Assessment</topic><topic>RNA, Messenger - analysis</topic><topic>RNA-Binding Proteins - genetics</topic><topic>RNA-Binding Proteins - metabolism</topic><topic>Sensitivity and Specificity</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Statistics, Nonparametric</topic><topic>Survival Analysis</topic><topic>Tissue Culture Techniques</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sunavala-Dossabhoy, Gulshan</creatorcontrib><creatorcontrib>Palaniyandi, Senthilnathan</creatorcontrib><creatorcontrib>Clark, Cheryl</creatorcontrib><creatorcontrib>Nathan, Cherie-Ann O.</creatorcontrib><creatorcontrib>Abreo, Fleurette W.</creatorcontrib><creatorcontrib>Caldito, Gloria</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sunavala-Dossabhoy, Gulshan</au><au>Palaniyandi, Senthilnathan</au><au>Clark, Cheryl</au><au>Nathan, Cherie-Ann O.</au><au>Abreo, Fleurette W.</au><au>Caldito, Gloria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of eIF4E and 4EBP1 mRNAs in head and neck cancer</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2011-10</date><risdate>2011</risdate><volume>121</volume><issue>10</issue><spage>2136</spage><epage>2141</epage><pages>2136-2141</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Objectives/Hypothesis:
The eukaryotic translation initiation factor 4E (eIF4E) in conjunction with its binding protein, 4EBP1, regulates the translation of cap‐dependent mRNAs. An aberrant increase in eIF4E shifts the balance in favor of translation of transcripts that promote cell proliferation and malignancy. eIF4E protein is commonly elevated in head and neck squamous cell carcinomas (HNSCC), and its overexpression is associated with increased recurrence. An underlying mechanism for eIF4E overexpression is gene amplification, and we wanted to determine whether eIF4E mRNA could serve as a prognostic maker of HNSCC.
Methods:
Tumor specimens from 26 HNSCC patients and oral tissues from 17 control subjects were examined for eIF4E and 4EBP1 by semiquantitative RT‐PCR and correlated with clinical and pathologic findings.
Results:
Unlike eIF4E mRNA alone, expression of eIF4E relative to 4EBP1 was a more precise predictor of HNSCC and its progression (P < .01, Wilcoxon rank sum test). Eight of 26 patients (31%) had elevated eIF4E:4EBP1 (4E:4EBP1; >25), and 7 of these (87.5%) had recurrence. Alternately, from 18 patients with low 4E:4EBP1 (<25; 69%), only 5 patients had recurrence (30.1%). To determine the probability of no recurrence, Kaplan–Meier analysis showed significantly poor disease‐free survival in patients with elevated 4E:4EBP1 than those with low ratios (P < .01, log rank test).
Conclusions:
Elevated 4E:4EBP1 significantly correlated with increased disease recurrence. Because 4EBP1 modulates eIF4E activity, our results highlight the importance of incorporating a joint analysis of eIF4E and 4EBP1 mRNAs in HNSCC patient care decisions.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21898433</pmid><doi>10.1002/lary.22144</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Laryngoscope, 2011-10, Vol.121 (10), p.2136-2141 |
| issn | 0023-852X 1531-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_894817155 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | 4EBP1 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adult Aged Biological and medical sciences biomarker Biomarkers, Tumor - metabolism Biopsy, Needle Carcinoma - genetics Carcinoma - mortality Carcinoma - pathology Carcinoma, Squamous Cell Chi-Square Distribution Cohort Studies Disease Progression eIF4E Eukaryotic Initiation Factor-4E - genetics Eukaryotic Initiation Factor-4E - metabolism Female head and neck cancer Head and Neck Neoplasms - genetics Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Humans Level 2b Level of Evidence: Prognosis Study Level of Evidence: Prognosis Study, Level 2b Male Medical sciences Middle Aged Neoplasm Invasiveness - pathology Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - metabolism Neoplasm Staging Neoplasms, Squamous Cell - genetics Neoplasms, Squamous Cell - mortality Neoplasms, Squamous Cell - pathology Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Predictive Value of Tests Prognosis Reverse Transcriptase Polymerase Chain Reaction Risk Assessment RNA, Messenger - analysis RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Sensitivity and Specificity Squamous Cell Carcinoma of Head and Neck Statistics, Nonparametric Survival Analysis Tissue Culture Techniques Tumors |
| title | Analysis of eIF4E and 4EBP1 mRNAs in head and neck cancer |
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