Astrocyte Dysfunction Associated with Cerebellar Attrition in a Nijmegen Breakage Syndrome Animal Model

Nijmegen breakage syndrome (NBS) is a genomic instability disorder caused by hypomorphic mutations in the Nbs1 gene. When Nbs1 is conditionally inactivated in the central nervous system of mice (Nbs1-CNS-Δ), they suffer from severe cerebellar atrophy, ataxia, and white matter damage. Here, we show t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular neuroscience 2011-10, Vol.45 (2), p.202-211
Hauptverfasser:	Galron, Ronit, Gruber, Ralph, Lifshitz, Veronica, Lu, Haizhen, Kirshner, Michal, Ziv, Natali, Wang, Zhao-Qi, Shiloh, Yosef, Barzilai, Ari, Frenkel, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animal models Animals Antibodies Astrocytes Astrocytes - cytology Astrocytes - physiology Ataxia Atrophy Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Cell Biology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cells, Cultured Central nervous system Cerebellum Cerebellum - cytology Cerebellum - pathology Disease Models, Animal Etiology Gene Silencing Genes Genomic instability Glial fibrillary acidic protein Glutamate-ammonia ligase Humans Immune system Mice Mice, Transgenic Microcephaly Microglia - cytology Microglia - metabolism Microglial cells Mutation NBS1 gene Nervous system Neurochemistry Neurology Neurosciences Neurotrophic factors Neurotrophin 3 Nijmegen breakage syndrome Nijmegen Breakage Syndrome - genetics Nijmegen Breakage Syndrome - pathology Nijmegen Breakage Syndrome - physiopathology Nuclear Proteins - genetics Nuclear Proteins - metabolism Pathogenesis Proteins Proteomics Radiation Secretion Substantia alba
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!