Do antioxidant vitamins have an anti-arrhythmic effect following cardiac surgery? A meta-analysis of randomised controlled trials
BackgroundPostoperative atrial fibrillation (POAF) affects approximately 30% of patients undergoing elective cardiac surgery. While its pathogenesis is multifactorial, increasing evidence supports a role for oxidative stress in the electrophysiological remodelling associated with AF. Although prophy...
Gespeichert in:
| Veröffentlicht in: | Heart (British Cardiac Society) 2011-10, Vol.97 (20), p.1636-1642 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1642 |
|---|---|
| container_issue | 20 |
| container_start_page | 1636 |
| container_title | Heart (British Cardiac Society) |
| container_volume | 97 |
| creator | Harling, Leanne Rasoli, Sonia Vecht, Joshua A Ashrafian, Hutan Kourliouros, Antonios Athanasiou, Thanos |
| description | BackgroundPostoperative atrial fibrillation (POAF) affects approximately 30% of patients undergoing elective cardiac surgery. While its pathogenesis is multifactorial, increasing evidence supports a role for oxidative stress in the electrophysiological remodelling associated with AF. Although prophylactic antioxidants appear to be a potentially attractive pharmacotherapy, there is still uncertainty regarding their efficacy. This study aims to provide a quantitative summary of the current evidence surrounding antioxidant vitamins and POAF prevention.MethodsA systematic literature review identified five randomised controlled trials incorporating 567 patients (n=284 antioxidant, n=283 control). These were meta-analysed using random effects modelling. Heterogeneity, subgroup analysis, quality scoring and risk of bias were assessed. Primary endpoints were the incidence of POAF and all-cause arrhythmia. Secondary endpoints were length of stay in the intensive care unit (ITU) and length of hospital stay.ResultsVitamins C and E significantly reduced the incidence of POAF (OR 0.43, 95% CI 0.21 to 0.89) and all-cause arrhythmia (OR 0.54, 95% CI 0.29 to 0.99) compared with controls. A significant reduction in both ITU stay (weighted mean difference (WMD) −0.44, 95% CI −0.70 to −0.17) and hospital stay (WMD −1.11, 95% CI −1.70 to −0.52) was also seen in the antioxidant group, without significant heterogeneity.ConclusionsThe prophylactic use of vitamins C and E may significantly reduce the incidence of POAF and all-cause arrhythmia following cardiac surgery. However, the overall quality of current studies is poor and further research should focus on adequately powered randomised controlled trials that standardise AF reporting, antioxidant protocol and the use of concomitant agents. Cost analysis should be considered to establish the potential economic benefit of antioxidant vitamin prophylaxis in POAF. |
| doi_str_mv | 10.1136/heartjnl-2011-300245 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_894813808</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4020964711</sourcerecordid><originalsourceid>FETCH-LOGICAL-b442t-f5fab8e962fe0f67e9766e7f9740153bb73f2de7f22601a34d113f6ac9285c3e3</originalsourceid><addsrcrecordid>eNqNkU1vFDEMhkcIREvhHyAUCSFOQ_M1SeaEqoUCUgUcStVb5Mkk3Swzk5JkSvfIPyfLbIvECflgy35s2X6r6jnBbwhh4nhtIebNNNQUE1IzjClvHlSHhAu1S10-LDFrmlpgJg-qJyltMMa8VeJxdUCJEg3F9LD69S4gmLIPt74vHt34DKOfElrDjS2VP8UaYlxv83r0BlnnrMnIhWEIP_10hQzE3oNBaY5XNm7fohM02gw1TDBsk08oOBRh6sPok-2RCVOOpbmEOXoY0tPqkSvOPtv7o-rb6fvz1cf67MuHT6uTs7rjnObaNQ46ZVtBncVOSNtKIax0reSYNKzrJHO0LwlKBSbAeF--5ASYlqrGMMuOqtfL3OsYfsw2ZV0WMnYYYLJhTlq1XBGmsCrky3_ITZhjOSdpIhWWpJgsFF8oE0NK0Tp9Hf0IcasJ1juF9J1CeqeQXhQqbS_2w-dutP19050kBXi1ByAZGFz5nfHpL8cbQYVsC1cvnE_Z3t7XIX7XQjLZ6M8XKy3PL04bfPlV7646Xvhu3Pzfqr8BQAi7gg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780717177</pqid></control><display><type>article</type><title>Do antioxidant vitamins have an anti-arrhythmic effect following cardiac surgery? A meta-analysis of randomised controlled trials</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Harling, Leanne ; Rasoli, Sonia ; Vecht, Joshua A ; Ashrafian, Hutan ; Kourliouros, Antonios ; Athanasiou, Thanos</creator><creatorcontrib>Harling, Leanne ; Rasoli, Sonia ; Vecht, Joshua A ; Ashrafian, Hutan ; Kourliouros, Antonios ; Athanasiou, Thanos</creatorcontrib><description>BackgroundPostoperative atrial fibrillation (POAF) affects approximately 30% of patients undergoing elective cardiac surgery. While its pathogenesis is multifactorial, increasing evidence supports a role for oxidative stress in the electrophysiological remodelling associated with AF. Although prophylactic antioxidants appear to be a potentially attractive pharmacotherapy, there is still uncertainty regarding their efficacy. This study aims to provide a quantitative summary of the current evidence surrounding antioxidant vitamins and POAF prevention.MethodsA systematic literature review identified five randomised controlled trials incorporating 567 patients (n=284 antioxidant, n=283 control). These were meta-analysed using random effects modelling. Heterogeneity, subgroup analysis, quality scoring and risk of bias were assessed. Primary endpoints were the incidence of POAF and all-cause arrhythmia. Secondary endpoints were length of stay in the intensive care unit (ITU) and length of hospital stay.ResultsVitamins C and E significantly reduced the incidence of POAF (OR 0.43, 95% CI 0.21 to 0.89) and all-cause arrhythmia (OR 0.54, 95% CI 0.29 to 0.99) compared with controls. A significant reduction in both ITU stay (weighted mean difference (WMD) −0.44, 95% CI −0.70 to −0.17) and hospital stay (WMD −1.11, 95% CI −1.70 to −0.52) was also seen in the antioxidant group, without significant heterogeneity.ConclusionsThe prophylactic use of vitamins C and E may significantly reduce the incidence of POAF and all-cause arrhythmia following cardiac surgery. However, the overall quality of current studies is poor and further research should focus on adequately powered randomised controlled trials that standardise AF reporting, antioxidant protocol and the use of concomitant agents. Cost analysis should be considered to establish the potential economic benefit of antioxidant vitamin prophylaxis in POAF.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2011-300245</identifier><identifier>PMID: 21865202</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Antioxidants - therapeutic use ; aortic valve disease ; Arrhythmias, Cardiac - etiology ; Arrhythmias, Cardiac - physiopathology ; Arrhythmias, Cardiac - prevention & control ; Atrial fibrillation ; Biological and medical sciences ; Cardiac arrhythmia ; cardiac surgery ; Cardiac Surgical Procedures - adverse effects ; Cardiology. Vascular system ; cardiopulmonary bypass ; Heart Rate - drug effects ; Humans ; IHD ; Medical sciences ; metabolic medicine ; methodology ; oxidative stress ; paediatric surgury ; Randomized Controlled Trials as Topic ; statins ; Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; surgery-coronary bypass ; Treatment Outcome ; Vitamin C ; Vitamin E ; Vitamins - therapeutic use</subject><ispartof>Heart (British Cardiac Society), 2011-10, Vol.97 (20), p.1636-1642</ispartof><rights>2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b442t-f5fab8e962fe0f67e9766e7f9740153bb73f2de7f22601a34d113f6ac9285c3e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://heart.bmj.com/content/97/20/1636.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://heart.bmj.com/content/97/20/1636.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,313,314,778,782,790,3185,23558,27909,27911,27912,77355,77386</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24562679$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21865202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harling, Leanne</creatorcontrib><creatorcontrib>Rasoli, Sonia</creatorcontrib><creatorcontrib>Vecht, Joshua A</creatorcontrib><creatorcontrib>Ashrafian, Hutan</creatorcontrib><creatorcontrib>Kourliouros, Antonios</creatorcontrib><creatorcontrib>Athanasiou, Thanos</creatorcontrib><title>Do antioxidant vitamins have an anti-arrhythmic effect following cardiac surgery? A meta-analysis of randomised controlled trials</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>BackgroundPostoperative atrial fibrillation (POAF) affects approximately 30% of patients undergoing elective cardiac surgery. While its pathogenesis is multifactorial, increasing evidence supports a role for oxidative stress in the electrophysiological remodelling associated with AF. Although prophylactic antioxidants appear to be a potentially attractive pharmacotherapy, there is still uncertainty regarding their efficacy. This study aims to provide a quantitative summary of the current evidence surrounding antioxidant vitamins and POAF prevention.MethodsA systematic literature review identified five randomised controlled trials incorporating 567 patients (n=284 antioxidant, n=283 control). These were meta-analysed using random effects modelling. Heterogeneity, subgroup analysis, quality scoring and risk of bias were assessed. Primary endpoints were the incidence of POAF and all-cause arrhythmia. Secondary endpoints were length of stay in the intensive care unit (ITU) and length of hospital stay.ResultsVitamins C and E significantly reduced the incidence of POAF (OR 0.43, 95% CI 0.21 to 0.89) and all-cause arrhythmia (OR 0.54, 95% CI 0.29 to 0.99) compared with controls. A significant reduction in both ITU stay (weighted mean difference (WMD) −0.44, 95% CI −0.70 to −0.17) and hospital stay (WMD −1.11, 95% CI −1.70 to −0.52) was also seen in the antioxidant group, without significant heterogeneity.ConclusionsThe prophylactic use of vitamins C and E may significantly reduce the incidence of POAF and all-cause arrhythmia following cardiac surgery. However, the overall quality of current studies is poor and further research should focus on adequately powered randomised controlled trials that standardise AF reporting, antioxidant protocol and the use of concomitant agents. Cost analysis should be considered to establish the potential economic benefit of antioxidant vitamin prophylaxis in POAF.</description><subject>Antioxidants - therapeutic use</subject><subject>aortic valve disease</subject><subject>Arrhythmias, Cardiac - etiology</subject><subject>Arrhythmias, Cardiac - physiopathology</subject><subject>Arrhythmias, Cardiac - prevention & control</subject><subject>Atrial fibrillation</subject><subject>Biological and medical sciences</subject><subject>Cardiac arrhythmia</subject><subject>cardiac surgery</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Cardiology. Vascular system</subject><subject>cardiopulmonary bypass</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>IHD</subject><subject>Medical sciences</subject><subject>metabolic medicine</subject><subject>methodology</subject><subject>oxidative stress</subject><subject>paediatric surgury</subject><subject>Randomized Controlled Trials as Topic</subject><subject>statins</subject><subject>Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>surgery-coronary bypass</subject><subject>Treatment Outcome</subject><subject>Vitamin C</subject><subject>Vitamin E</subject><subject>Vitamins - therapeutic use</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1vFDEMhkcIREvhHyAUCSFOQ_M1SeaEqoUCUgUcStVb5Mkk3Swzk5JkSvfIPyfLbIvECflgy35s2X6r6jnBbwhh4nhtIebNNNQUE1IzjClvHlSHhAu1S10-LDFrmlpgJg-qJyltMMa8VeJxdUCJEg3F9LD69S4gmLIPt74vHt34DKOfElrDjS2VP8UaYlxv83r0BlnnrMnIhWEIP_10hQzE3oNBaY5XNm7fohM02gw1TDBsk08oOBRh6sPok-2RCVOOpbmEOXoY0tPqkSvOPtv7o-rb6fvz1cf67MuHT6uTs7rjnObaNQ46ZVtBncVOSNtKIax0reSYNKzrJHO0LwlKBSbAeF--5ASYlqrGMMuOqtfL3OsYfsw2ZV0WMnYYYLJhTlq1XBGmsCrky3_ITZhjOSdpIhWWpJgsFF8oE0NK0Tp9Hf0IcasJ1juF9J1CeqeQXhQqbS_2w-dutP19050kBXi1ByAZGFz5nfHpL8cbQYVsC1cvnE_Z3t7XIX7XQjLZ6M8XKy3PL04bfPlV7646Xvhu3Pzfqr8BQAi7gg</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Harling, Leanne</creator><creator>Rasoli, Sonia</creator><creator>Vecht, Joshua A</creator><creator>Ashrafian, Hutan</creator><creator>Kourliouros, Antonios</creator><creator>Athanasiou, Thanos</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Do antioxidant vitamins have an anti-arrhythmic effect following cardiac surgery? A meta-analysis of randomised controlled trials</title><author>Harling, Leanne ; Rasoli, Sonia ; Vecht, Joshua A ; Ashrafian, Hutan ; Kourliouros, Antonios ; Athanasiou, Thanos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b442t-f5fab8e962fe0f67e9766e7f9740153bb73f2de7f22601a34d113f6ac9285c3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Antioxidants - therapeutic use</topic><topic>aortic valve disease</topic><topic>Arrhythmias, Cardiac - etiology</topic><topic>Arrhythmias, Cardiac - physiopathology</topic><topic>Arrhythmias, Cardiac - prevention & control</topic><topic>Atrial fibrillation</topic><topic>Biological and medical sciences</topic><topic>Cardiac arrhythmia</topic><topic>cardiac surgery</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Cardiology. Vascular system</topic><topic>cardiopulmonary bypass</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>IHD</topic><topic>Medical sciences</topic><topic>metabolic medicine</topic><topic>methodology</topic><topic>oxidative stress</topic><topic>paediatric surgury</topic><topic>Randomized Controlled Trials as Topic</topic><topic>statins</topic><topic>Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>surgery-coronary bypass</topic><topic>Treatment Outcome</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><topic>Vitamins - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harling, Leanne</creatorcontrib><creatorcontrib>Rasoli, Sonia</creatorcontrib><creatorcontrib>Vecht, Joshua A</creatorcontrib><creatorcontrib>Ashrafian, Hutan</creatorcontrib><creatorcontrib>Kourliouros, Antonios</creatorcontrib><creatorcontrib>Athanasiou, Thanos</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harling, Leanne</au><au>Rasoli, Sonia</au><au>Vecht, Joshua A</au><au>Ashrafian, Hutan</au><au>Kourliouros, Antonios</au><au>Athanasiou, Thanos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do antioxidant vitamins have an anti-arrhythmic effect following cardiac surgery? A meta-analysis of randomised controlled trials</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>97</volume><issue>20</issue><spage>1636</spage><epage>1642</epage><pages>1636-1642</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>BackgroundPostoperative atrial fibrillation (POAF) affects approximately 30% of patients undergoing elective cardiac surgery. While its pathogenesis is multifactorial, increasing evidence supports a role for oxidative stress in the electrophysiological remodelling associated with AF. Although prophylactic antioxidants appear to be a potentially attractive pharmacotherapy, there is still uncertainty regarding their efficacy. This study aims to provide a quantitative summary of the current evidence surrounding antioxidant vitamins and POAF prevention.MethodsA systematic literature review identified five randomised controlled trials incorporating 567 patients (n=284 antioxidant, n=283 control). These were meta-analysed using random effects modelling. Heterogeneity, subgroup analysis, quality scoring and risk of bias were assessed. Primary endpoints were the incidence of POAF and all-cause arrhythmia. Secondary endpoints were length of stay in the intensive care unit (ITU) and length of hospital stay.ResultsVitamins C and E significantly reduced the incidence of POAF (OR 0.43, 95% CI 0.21 to 0.89) and all-cause arrhythmia (OR 0.54, 95% CI 0.29 to 0.99) compared with controls. A significant reduction in both ITU stay (weighted mean difference (WMD) −0.44, 95% CI −0.70 to −0.17) and hospital stay (WMD −1.11, 95% CI −1.70 to −0.52) was also seen in the antioxidant group, without significant heterogeneity.ConclusionsThe prophylactic use of vitamins C and E may significantly reduce the incidence of POAF and all-cause arrhythmia following cardiac surgery. However, the overall quality of current studies is poor and further research should focus on adequately powered randomised controlled trials that standardise AF reporting, antioxidant protocol and the use of concomitant agents. Cost analysis should be considered to establish the potential economic benefit of antioxidant vitamin prophylaxis in POAF.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>21865202</pmid><doi>10.1136/heartjnl-2011-300245</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6037 |
| ispartof | Heart (British Cardiac Society), 2011-10, Vol.97 (20), p.1636-1642 |
| issn | 1355-6037 1468-201X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_894813808 |
| source | MEDLINE; BMJ Journals - NESLi2; PubMed Central |
| subjects | Antioxidants - therapeutic use aortic valve disease Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - physiopathology Arrhythmias, Cardiac - prevention & control Atrial fibrillation Biological and medical sciences Cardiac arrhythmia cardiac surgery Cardiac Surgical Procedures - adverse effects Cardiology. Vascular system cardiopulmonary bypass Heart Rate - drug effects Humans IHD Medical sciences metabolic medicine methodology oxidative stress paediatric surgury Randomized Controlled Trials as Topic statins Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart surgery-coronary bypass Treatment Outcome Vitamin C Vitamin E Vitamins - therapeutic use |
| title | Do antioxidant vitamins have an anti-arrhythmic effect following cardiac surgery? A meta-analysis of randomised controlled trials |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T16%3A04%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Do%20antioxidant%20vitamins%20have%20an%20anti-arrhythmic%20effect%20following%20cardiac%20surgery?%20A%20meta-analysis%20of%20randomised%20controlled%20trials&rft.jtitle=Heart%20(British%20Cardiac%20Society)&rft.au=Harling,%20Leanne&rft.date=2011-10-01&rft.volume=97&rft.issue=20&rft.spage=1636&rft.epage=1642&rft.pages=1636-1642&rft.issn=1355-6037&rft.eissn=1468-201X&rft_id=info:doi/10.1136/heartjnl-2011-300245&rft_dat=%3Cproquest_cross%3E4020964711%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1780717177&rft_id=info:pmid/21865202&rfr_iscdi=true |