Characteristics and long-term outcome of echocardiographic super-responders to cardiac resynchronisation therapy: ‘real world’ experience from a single tertiary care centre
BackgroundThe individual benefit from cardiac resynchronisation therapy (CRT) varies largely among patients.AimsTo compare different definitions of echocardiographic super-response to CRT regarding their ability to predict the incidence of adverse events.MethodsThree definitions of super-response to...
Gespeichert in:
| Veröffentlicht in: | Heart (British Cardiac Society) 2011-10, Vol.97 (20), p.1668-1674 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1674 |
|---|---|
| container_issue | 20 |
| container_start_page | 1668 |
| container_title | Heart (British Cardiac Society) |
| container_volume | 97 |
| creator | Steffel, Jan Milosevic, Gligor Hürlimann, Anja Krasniqi, Nazmi Namdar, Mehdi Ruschitzka, Frank Lüscher, Thomas F Duru, Firat Holzmeister, Johannes Hürlimann, David |
| description | BackgroundThe individual benefit from cardiac resynchronisation therapy (CRT) varies largely among patients.AimsTo compare different definitions of echocardiographic super-response to CRT regarding their ability to predict the incidence of adverse events.MethodsThree definitions of super-response to CRT were evaluated in 110 consecutive patients with CRT implantation: (1) an absolute increase in ejection fraction of ≥10%; (2) a decrease in left ventricular end-systolic volume of ≥30%; and (3) a decrease in left ventricular end-diastolic volume of ≥20%. The primary endpoint was a combination of time to death, heart transplantation, ventricular assist device implantation and hospitalisation for heart failure. Secondary endpoints included time to first appropriate implantable cardioverter defibrillator (ICD) discharge during follow-up.ResultsAll three definitions of super-response were highly predictive of a reduced risk for reaching the primary combined endpoint (3-year estimators: 64%±7% vs 82%±7% for ejection fraction ≥10%; 63%±8% vs 92%±5% for end-systolic volume ≥30%; and 62%±8% vs 94%±4% for end-diastolic volume ≥20%; all p |
| doi_str_mv | 10.1136/heartjnl-2011-300222 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_894813785</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4020964741</sourcerecordid><originalsourceid>FETCH-LOGICAL-b442t-1688d7dd8c6227da45f74803eacde85dbed334881c3de94a8a6e8ba59ea2ea533</originalsourceid><addsrcrecordid>eNqNkc-KFDEQhxtR3HX1DUQCIp7aTTrpdMabO_gPBkVcxVuoSaqnM3YnY9KNO7d9DH0Ln2mfxIwzu4InIZBQ-epHFV9RPGT0GWNcnnYIcVz7vqwoYyWntKqqW8UxE1LtSl9u5zev61JS3hwV91JaU0rFTMm7xVHFVD61PC5-zTuIYEaMLo3OJALekj74VZlLAwnTaMKAJLQETRcMROvCKsKmc4akaYOxjJg2wVuMiYyB_CHAkFzdetPF4F2C0QVPxg5z3_Y5ubr8ERF68j3E3l5d_iR4kXMceoOkjWEgQJLzqx5JHmF0ELe7VCQG_RjxfnGnhT7hg8N9Unx69fJ8_qZcvH_9dv5iUS6FqMaSSaVsY60ysqoaC6JuG6EoRzAWVW2XaDkXSjHDLc4EKJCollDPECqEmvOT4uk-dxPDtwnTqAeXDPY9eAxT0momFOONqjP5-B9yHabo83CaNYo2rMlqMiX2lIkhpYit3kQ35OU0o3onVF8L1Tuhei80tz06hE_LAe1N07XBDDw5AJAM9G0Eb1z6y4laVlKJzJV7LnvGi5t_iF-1bHhT63ef5_r8rD6jHz9Qvcj86Z5fDuv_G_U3GUPQdg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780717022</pqid></control><display><type>article</type><title>Characteristics and long-term outcome of echocardiographic super-responders to cardiac resynchronisation therapy: ‘real world’ experience from a single tertiary care centre</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Steffel, Jan ; Milosevic, Gligor ; Hürlimann, Anja ; Krasniqi, Nazmi ; Namdar, Mehdi ; Ruschitzka, Frank ; Lüscher, Thomas F ; Duru, Firat ; Holzmeister, Johannes ; Hürlimann, David</creator><creatorcontrib>Steffel, Jan ; Milosevic, Gligor ; Hürlimann, Anja ; Krasniqi, Nazmi ; Namdar, Mehdi ; Ruschitzka, Frank ; Lüscher, Thomas F ; Duru, Firat ; Holzmeister, Johannes ; Hürlimann, David</creatorcontrib><description>BackgroundThe individual benefit from cardiac resynchronisation therapy (CRT) varies largely among patients.AimsTo compare different definitions of echocardiographic super-response to CRT regarding their ability to predict the incidence of adverse events.MethodsThree definitions of super-response to CRT were evaluated in 110 consecutive patients with CRT implantation: (1) an absolute increase in ejection fraction of ≥10%; (2) a decrease in left ventricular end-systolic volume of ≥30%; and (3) a decrease in left ventricular end-diastolic volume of ≥20%. The primary endpoint was a combination of time to death, heart transplantation, ventricular assist device implantation and hospitalisation for heart failure. Secondary endpoints included time to first appropriate implantable cardioverter defibrillator (ICD) discharge during follow-up.ResultsAll three definitions of super-response were highly predictive of a reduced risk for reaching the primary combined endpoint (3-year estimators: 64%±7% vs 82%±7% for ejection fraction ≥10%; 63%±8% vs 92%±5% for end-systolic volume ≥30%; and 62%±8% vs 94%±4% for end-diastolic volume ≥20%; all p<0.001). In all three analyses, super-responders had a significantly shorter time from diagnosis of heart failure until the time point of CRT implantation. However, even super-responders, independent of the definition, did experience appropriate ICD discharges during follow-up.ConclusionsAll three definitions of super-response are highly predictive for a favourable outcome after CRT. However, even patients with pronounced reverse left ventricular remodelling experience appropriate ICD discharges during follow-up.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2011-300222</identifier><identifier>PMID: 21821856</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>atrial fibrillation ; atrial flutter ; Biological and medical sciences ; brugada ; Cardiac arrhythmia ; Cardiac resynchronisation therapy (CRT) ; Cardiac Resynchronization Therapy - methods ; Cardiology. Vascular system ; cardiomyopathy hypertrophic ; cardiomyopathy restrictive ; Cardiovascular disease ; Cardiovascular system ; coronary artery disease (CAD) ; defibrillation ; Defibrillators, Implantable ; EBM ; Echocardiography ; endocardial map ; Female ; Follow-Up Studies ; Heart attacks ; Heart failure ; Heart Failure - diagnostic imaging ; Heart Failure - physiopathology ; Heart Failure - therapy ; heart failure treatment ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - physiopathology ; Humans ; implantable cardioverter defibrillator (ICD) ; Investigative techniques, diagnostic techniques (general aspects) ; long-term survival arrhythmias ; Male ; Medical sciences ; Middle Aged ; Mortality ; NSTEMI ; nuclear cardiology ; pacemakers ; Patients ; radiofrequency ablation (RFA) ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Reproducibility of Results ; Retrospective Studies ; sick sinus syndrome ; stable angina ; STEMI ; Stroke Volume - physiology ; sudden cardiac death ; super-responder ; syncope ; Time Factors ; tissue doppler ; Transplants & implants ; Treatment Outcome ; Ultrasonic investigative techniques ; Ventricular Function - physiology</subject><ispartof>Heart (British Cardiac Society), 2011-10, Vol.97 (20), p.1668-1674</ispartof><rights>2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b442t-1688d7dd8c6227da45f74803eacde85dbed334881c3de94a8a6e8ba59ea2ea533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://heart.bmj.com/content/97/20/1668.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://heart.bmj.com/content/97/20/1668.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77342,77373</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24562684$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21821856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steffel, Jan</creatorcontrib><creatorcontrib>Milosevic, Gligor</creatorcontrib><creatorcontrib>Hürlimann, Anja</creatorcontrib><creatorcontrib>Krasniqi, Nazmi</creatorcontrib><creatorcontrib>Namdar, Mehdi</creatorcontrib><creatorcontrib>Ruschitzka, Frank</creatorcontrib><creatorcontrib>Lüscher, Thomas F</creatorcontrib><creatorcontrib>Duru, Firat</creatorcontrib><creatorcontrib>Holzmeister, Johannes</creatorcontrib><creatorcontrib>Hürlimann, David</creatorcontrib><title>Characteristics and long-term outcome of echocardiographic super-responders to cardiac resynchronisation therapy: ‘real world’ experience from a single tertiary care centre</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>BackgroundThe individual benefit from cardiac resynchronisation therapy (CRT) varies largely among patients.AimsTo compare different definitions of echocardiographic super-response to CRT regarding their ability to predict the incidence of adverse events.MethodsThree definitions of super-response to CRT were evaluated in 110 consecutive patients with CRT implantation: (1) an absolute increase in ejection fraction of ≥10%; (2) a decrease in left ventricular end-systolic volume of ≥30%; and (3) a decrease in left ventricular end-diastolic volume of ≥20%. The primary endpoint was a combination of time to death, heart transplantation, ventricular assist device implantation and hospitalisation for heart failure. Secondary endpoints included time to first appropriate implantable cardioverter defibrillator (ICD) discharge during follow-up.ResultsAll three definitions of super-response were highly predictive of a reduced risk for reaching the primary combined endpoint (3-year estimators: 64%±7% vs 82%±7% for ejection fraction ≥10%; 63%±8% vs 92%±5% for end-systolic volume ≥30%; and 62%±8% vs 94%±4% for end-diastolic volume ≥20%; all p<0.001). In all three analyses, super-responders had a significantly shorter time from diagnosis of heart failure until the time point of CRT implantation. However, even super-responders, independent of the definition, did experience appropriate ICD discharges during follow-up.ConclusionsAll three definitions of super-response are highly predictive for a favourable outcome after CRT. However, even patients with pronounced reverse left ventricular remodelling experience appropriate ICD discharges during follow-up.</description><subject>atrial fibrillation</subject><subject>atrial flutter</subject><subject>Biological and medical sciences</subject><subject>brugada</subject><subject>Cardiac arrhythmia</subject><subject>Cardiac resynchronisation therapy (CRT)</subject><subject>Cardiac Resynchronization Therapy - methods</subject><subject>Cardiology. Vascular system</subject><subject>cardiomyopathy hypertrophic</subject><subject>cardiomyopathy restrictive</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular system</subject><subject>coronary artery disease (CAD)</subject><subject>defibrillation</subject><subject>Defibrillators, Implantable</subject><subject>EBM</subject><subject>Echocardiography</subject><subject>endocardial map</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart attacks</subject><subject>Heart failure</subject><subject>Heart Failure - diagnostic imaging</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - therapy</subject><subject>heart failure treatment</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>implantable cardioverter defibrillator (ICD)</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>long-term survival arrhythmias</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>NSTEMI</subject><subject>nuclear cardiology</subject><subject>pacemakers</subject><subject>Patients</subject><subject>radiofrequency ablation (RFA)</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>sick sinus syndrome</subject><subject>stable angina</subject><subject>STEMI</subject><subject>Stroke Volume - physiology</subject><subject>sudden cardiac death</subject><subject>super-responder</subject><subject>syncope</subject><subject>Time Factors</subject><subject>tissue doppler</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>Ultrasonic investigative techniques</subject><subject>Ventricular Function - physiology</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc-KFDEQhxtR3HX1DUQCIp7aTTrpdMabO_gPBkVcxVuoSaqnM3YnY9KNO7d9DH0Ln2mfxIwzu4InIZBQ-epHFV9RPGT0GWNcnnYIcVz7vqwoYyWntKqqW8UxE1LtSl9u5zev61JS3hwV91JaU0rFTMm7xVHFVD61PC5-zTuIYEaMLo3OJALekj74VZlLAwnTaMKAJLQETRcMROvCKsKmc4akaYOxjJg2wVuMiYyB_CHAkFzdetPF4F2C0QVPxg5z3_Y5ubr8ERF68j3E3l5d_iR4kXMceoOkjWEgQJLzqx5JHmF0ELe7VCQG_RjxfnGnhT7hg8N9Unx69fJ8_qZcvH_9dv5iUS6FqMaSSaVsY60ysqoaC6JuG6EoRzAWVW2XaDkXSjHDLc4EKJCollDPECqEmvOT4uk-dxPDtwnTqAeXDPY9eAxT0momFOONqjP5-B9yHabo83CaNYo2rMlqMiX2lIkhpYit3kQ35OU0o3onVF8L1Tuhei80tz06hE_LAe1N07XBDDw5AJAM9G0Eb1z6y4laVlKJzJV7LnvGi5t_iF-1bHhT63ef5_r8rD6jHz9Qvcj86Z5fDuv_G_U3GUPQdg</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Steffel, Jan</creator><creator>Milosevic, Gligor</creator><creator>Hürlimann, Anja</creator><creator>Krasniqi, Nazmi</creator><creator>Namdar, Mehdi</creator><creator>Ruschitzka, Frank</creator><creator>Lüscher, Thomas F</creator><creator>Duru, Firat</creator><creator>Holzmeister, Johannes</creator><creator>Hürlimann, David</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Characteristics and long-term outcome of echocardiographic super-responders to cardiac resynchronisation therapy: ‘real world’ experience from a single tertiary care centre</title><author>Steffel, Jan ; Milosevic, Gligor ; Hürlimann, Anja ; Krasniqi, Nazmi ; Namdar, Mehdi ; Ruschitzka, Frank ; Lüscher, Thomas F ; Duru, Firat ; Holzmeister, Johannes ; Hürlimann, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b442t-1688d7dd8c6227da45f74803eacde85dbed334881c3de94a8a6e8ba59ea2ea533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>atrial fibrillation</topic><topic>atrial flutter</topic><topic>Biological and medical sciences</topic><topic>brugada</topic><topic>Cardiac arrhythmia</topic><topic>Cardiac resynchronisation therapy (CRT)</topic><topic>Cardiac Resynchronization Therapy - methods</topic><topic>Cardiology. Vascular system</topic><topic>cardiomyopathy hypertrophic</topic><topic>cardiomyopathy restrictive</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular system</topic><topic>coronary artery disease (CAD)</topic><topic>defibrillation</topic><topic>Defibrillators, Implantable</topic><topic>EBM</topic><topic>Echocardiography</topic><topic>endocardial map</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart attacks</topic><topic>Heart failure</topic><topic>Heart Failure - diagnostic imaging</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - therapy</topic><topic>heart failure treatment</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>implantable cardioverter defibrillator (ICD)</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>long-term survival arrhythmias</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>NSTEMI</topic><topic>nuclear cardiology</topic><topic>pacemakers</topic><topic>Patients</topic><topic>radiofrequency ablation (RFA)</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>sick sinus syndrome</topic><topic>stable angina</topic><topic>STEMI</topic><topic>Stroke Volume - physiology</topic><topic>sudden cardiac death</topic><topic>super-responder</topic><topic>syncope</topic><topic>Time Factors</topic><topic>tissue doppler</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>Ultrasonic investigative techniques</topic><topic>Ventricular Function - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steffel, Jan</creatorcontrib><creatorcontrib>Milosevic, Gligor</creatorcontrib><creatorcontrib>Hürlimann, Anja</creatorcontrib><creatorcontrib>Krasniqi, Nazmi</creatorcontrib><creatorcontrib>Namdar, Mehdi</creatorcontrib><creatorcontrib>Ruschitzka, Frank</creatorcontrib><creatorcontrib>Lüscher, Thomas F</creatorcontrib><creatorcontrib>Duru, Firat</creatorcontrib><creatorcontrib>Holzmeister, Johannes</creatorcontrib><creatorcontrib>Hürlimann, David</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steffel, Jan</au><au>Milosevic, Gligor</au><au>Hürlimann, Anja</au><au>Krasniqi, Nazmi</au><au>Namdar, Mehdi</au><au>Ruschitzka, Frank</au><au>Lüscher, Thomas F</au><au>Duru, Firat</au><au>Holzmeister, Johannes</au><au>Hürlimann, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics and long-term outcome of echocardiographic super-responders to cardiac resynchronisation therapy: ‘real world’ experience from a single tertiary care centre</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>97</volume><issue>20</issue><spage>1668</spage><epage>1674</epage><pages>1668-1674</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>BackgroundThe individual benefit from cardiac resynchronisation therapy (CRT) varies largely among patients.AimsTo compare different definitions of echocardiographic super-response to CRT regarding their ability to predict the incidence of adverse events.MethodsThree definitions of super-response to CRT were evaluated in 110 consecutive patients with CRT implantation: (1) an absolute increase in ejection fraction of ≥10%; (2) a decrease in left ventricular end-systolic volume of ≥30%; and (3) a decrease in left ventricular end-diastolic volume of ≥20%. The primary endpoint was a combination of time to death, heart transplantation, ventricular assist device implantation and hospitalisation for heart failure. Secondary endpoints included time to first appropriate implantable cardioverter defibrillator (ICD) discharge during follow-up.ResultsAll three definitions of super-response were highly predictive of a reduced risk for reaching the primary combined endpoint (3-year estimators: 64%±7% vs 82%±7% for ejection fraction ≥10%; 63%±8% vs 92%±5% for end-systolic volume ≥30%; and 62%±8% vs 94%±4% for end-diastolic volume ≥20%; all p<0.001). In all three analyses, super-responders had a significantly shorter time from diagnosis of heart failure until the time point of CRT implantation. However, even super-responders, independent of the definition, did experience appropriate ICD discharges during follow-up.ConclusionsAll three definitions of super-response are highly predictive for a favourable outcome after CRT. However, even patients with pronounced reverse left ventricular remodelling experience appropriate ICD discharges during follow-up.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>21821856</pmid><doi>10.1136/heartjnl-2011-300222</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6037 |
| ispartof | Heart (British Cardiac Society), 2011-10, Vol.97 (20), p.1668-1674 |
| issn | 1355-6037 1468-201X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_894813785 |
| source | MEDLINE; BMJ Journals - NESLi2; PubMed Central |
| subjects | atrial fibrillation atrial flutter Biological and medical sciences brugada Cardiac arrhythmia Cardiac resynchronisation therapy (CRT) Cardiac Resynchronization Therapy - methods Cardiology. Vascular system cardiomyopathy hypertrophic cardiomyopathy restrictive Cardiovascular disease Cardiovascular system coronary artery disease (CAD) defibrillation Defibrillators, Implantable EBM Echocardiography endocardial map Female Follow-Up Studies Heart attacks Heart failure Heart Failure - diagnostic imaging Heart Failure - physiopathology Heart Failure - therapy heart failure treatment Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans implantable cardioverter defibrillator (ICD) Investigative techniques, diagnostic techniques (general aspects) long-term survival arrhythmias Male Medical sciences Middle Aged Mortality NSTEMI nuclear cardiology pacemakers Patients radiofrequency ablation (RFA) Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Reproducibility of Results Retrospective Studies sick sinus syndrome stable angina STEMI Stroke Volume - physiology sudden cardiac death super-responder syncope Time Factors tissue doppler Transplants & implants Treatment Outcome Ultrasonic investigative techniques Ventricular Function - physiology |
| title | Characteristics and long-term outcome of echocardiographic super-responders to cardiac resynchronisation therapy: ‘real world’ experience from a single tertiary care centre |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T14%3A14%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Characteristics%20and%20long-term%20outcome%20of%20echocardiographic%20super-responders%20to%20cardiac%20resynchronisation%20therapy:%20%E2%80%98real%20world%E2%80%99%20experience%20from%20a%20single%20tertiary%20care%20centre&rft.jtitle=Heart%20(British%20Cardiac%20Society)&rft.au=Steffel,%20Jan&rft.date=2011-10-01&rft.volume=97&rft.issue=20&rft.spage=1668&rft.epage=1674&rft.pages=1668-1674&rft.issn=1355-6037&rft.eissn=1468-201X&rft_id=info:doi/10.1136/heartjnl-2011-300222&rft_dat=%3Cproquest_cross%3E4020964741%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1780717022&rft_id=info:pmid/21821856&rfr_iscdi=true |