Adjusting the timing of left-ventricular pacing using electrocardiogram and device electrograms
Aims Left-ventricular (LV) pacing with optimized atrio-ventricular (AV) timing may provide similar or greater benefit in comparison with bi-ventricular (BiV) pacing in a subset of cardiac resynchronization therapy (CRT) patients with sinus rhythm and preserved AV conduction. We hypothesized that the...
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creator | Khaykin, Yaariv Exner, Derek Birnie, David Sapp, John Aggarwal, Sandeep Sambelashvili, Aleksandre |
description | Aims
Left-ventricular (LV) pacing with optimized atrio-ventricular (AV) timing may provide similar or greater benefit in comparison with bi-ventricular (BiV) pacing in a subset of cardiac resynchronization therapy (CRT) patients with sinus rhythm and preserved AV conduction. We hypothesized that the optimal device AV delays during LV pacing can be predicted using electrocardiogram (ECG) and device electrograms.
Methods and results
Patients (n= 55) with sinus rhythm and PR interval < 300 ms had their CRT devices programmed to atrial and LV pacing with a range of AVs as well as to echocardiographically optimized BiV and no ventricular pacing. At each setting, LV function was evaluated using echocardiography and AVs corresponding to the highest LV ejection fraction (LVEF), lowest LV end-systolic volume (LVESV), and the average of the two (by EF and ESV) were determined. Correlation between the optimal AVs and the following intervals was investigated: intrinsic QRS duration (QRSs), intervals from atrial pacing (Ap) to right-ventricular (RV) sensing (Ap-RVs), from RV sensing to LV activation (RVs-LVs), and from LV pacing to RV sensing (LVp-RVs). Optimal AVs moderately correlated with intrinsic Ap-RVs interval, whereas other parameters showed weak or no correlation. The best correlation (R = 0.66, P< 0.0001) was between the optimal AV delay according to EF and ESV, and Ap-RVs interval. Programming of AVs during LV pacing to the shortest of 70% of the intrinsic Ap-RVs interval, or Ap-RVs-40 ms resulted in significant improvement in LV function similar to that in case of BiV.
Conclusion
Optimal AV during LV pacing can be approximated from the intrinsic AV conduction time. |
doi_str_mv | 10.1093/europace/eur146 |
format | Article |
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Left-ventricular (LV) pacing with optimized atrio-ventricular (AV) timing may provide similar or greater benefit in comparison with bi-ventricular (BiV) pacing in a subset of cardiac resynchronization therapy (CRT) patients with sinus rhythm and preserved AV conduction. We hypothesized that the optimal device AV delays during LV pacing can be predicted using electrocardiogram (ECG) and device electrograms.
Methods and results
Patients (n= 55) with sinus rhythm and PR interval < 300 ms had their CRT devices programmed to atrial and LV pacing with a range of AVs as well as to echocardiographically optimized BiV and no ventricular pacing. At each setting, LV function was evaluated using echocardiography and AVs corresponding to the highest LV ejection fraction (LVEF), lowest LV end-systolic volume (LVESV), and the average of the two (by EF and ESV) were determined. Correlation between the optimal AVs and the following intervals was investigated: intrinsic QRS duration (QRSs), intervals from atrial pacing (Ap) to right-ventricular (RV) sensing (Ap-RVs), from RV sensing to LV activation (RVs-LVs), and from LV pacing to RV sensing (LVp-RVs). Optimal AVs moderately correlated with intrinsic Ap-RVs interval, whereas other parameters showed weak or no correlation. The best correlation (R = 0.66, P< 0.0001) was between the optimal AV delay according to EF and ESV, and Ap-RVs interval. Programming of AVs during LV pacing to the shortest of 70% of the intrinsic Ap-RVs interval, or Ap-RVs-40 ms resulted in significant improvement in LV function similar to that in case of BiV.
Conclusion
Optimal AV during LV pacing can be approximated from the intrinsic AV conduction time.</description><identifier>ISSN: 1099-5129</identifier><identifier>EISSN: 1532-2092</identifier><identifier>DOI: 10.1093/europace/eur146</identifier><identifier>PMID: 21596719</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Aged ; Atrioventricular Block - physiopathology ; Atrioventricular Block - therapy ; Atrioventricular Node - physiopathology ; Bundle-Branch Block - physiopathology ; Bundle-Branch Block - therapy ; Cardiac Resynchronization Therapy - methods ; Cardiac Resynchronization Therapy Devices ; Electrocardiography - methods ; Electrophysiologic Techniques, Cardiac - methods ; Female ; Heart Conduction System - physiopathology ; Heart Ventricles - physiopathology ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Stroke Volume - physiology ; Treatment Outcome</subject><ispartof>Europace (London, England), 2011-10, Vol.13 (10), p.1464-1470</ispartof><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011. For permissions please email: journals.permissions@oup.com. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-649c131aed3e47f1ae908583975b73271d3632fc04c48c10f3aade819520ced23</citedby><cites>FETCH-LOGICAL-c438t-649c131aed3e47f1ae908583975b73271d3632fc04c48c10f3aade819520ced23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1604,27924,27925</link.rule.ids><linktorsrc>$$Uhttps://dx.doi.org/10.1093/europace/eur146$$EView_record_in_Oxford_University_Press$$FView_record_in_$$GOxford_University_Press</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21596719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khaykin, Yaariv</creatorcontrib><creatorcontrib>Exner, Derek</creatorcontrib><creatorcontrib>Birnie, David</creatorcontrib><creatorcontrib>Sapp, John</creatorcontrib><creatorcontrib>Aggarwal, Sandeep</creatorcontrib><creatorcontrib>Sambelashvili, Aleksandre</creatorcontrib><title>Adjusting the timing of left-ventricular pacing using electrocardiogram and device electrograms</title><title>Europace (London, England)</title><addtitle>Europace</addtitle><description>Aims
Left-ventricular (LV) pacing with optimized atrio-ventricular (AV) timing may provide similar or greater benefit in comparison with bi-ventricular (BiV) pacing in a subset of cardiac resynchronization therapy (CRT) patients with sinus rhythm and preserved AV conduction. We hypothesized that the optimal device AV delays during LV pacing can be predicted using electrocardiogram (ECG) and device electrograms.
Methods and results
Patients (n= 55) with sinus rhythm and PR interval < 300 ms had their CRT devices programmed to atrial and LV pacing with a range of AVs as well as to echocardiographically optimized BiV and no ventricular pacing. At each setting, LV function was evaluated using echocardiography and AVs corresponding to the highest LV ejection fraction (LVEF), lowest LV end-systolic volume (LVESV), and the average of the two (by EF and ESV) were determined. Correlation between the optimal AVs and the following intervals was investigated: intrinsic QRS duration (QRSs), intervals from atrial pacing (Ap) to right-ventricular (RV) sensing (Ap-RVs), from RV sensing to LV activation (RVs-LVs), and from LV pacing to RV sensing (LVp-RVs). Optimal AVs moderately correlated with intrinsic Ap-RVs interval, whereas other parameters showed weak or no correlation. The best correlation (R = 0.66, P< 0.0001) was between the optimal AV delay according to EF and ESV, and Ap-RVs interval. Programming of AVs during LV pacing to the shortest of 70% of the intrinsic Ap-RVs interval, or Ap-RVs-40 ms resulted in significant improvement in LV function similar to that in case of BiV.
Conclusion
Optimal AV during LV pacing can be approximated from the intrinsic AV conduction time.</description><subject>Aged</subject><subject>Atrioventricular Block - physiopathology</subject><subject>Atrioventricular Block - therapy</subject><subject>Atrioventricular Node - physiopathology</subject><subject>Bundle-Branch Block - physiopathology</subject><subject>Bundle-Branch Block - therapy</subject><subject>Cardiac Resynchronization Therapy - methods</subject><subject>Cardiac Resynchronization Therapy Devices</subject><subject>Electrocardiography - methods</subject><subject>Electrophysiologic Techniques, Cardiac - methods</subject><subject>Female</subject><subject>Heart Conduction System - physiopathology</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Stroke Volume - physiology</subject><subject>Treatment Outcome</subject><issn>1099-5129</issn><issn>1532-2092</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtLw0AQxhdRbK2evUlughC7rzz2WIovKHjR87LdndSUJBv3UfC_NyGtVy8zHzO_-QY-hG4JfiRYsCVEZ3ulYRSE52doTjJGU4oFPR80FiLNCBUzdOX9HmNcUJFdohklmcgLIuZIrsw--lB3uyR8QRLqdpS2ShqoQnqALrhax0a5ZHgzrqIfKzSgg7NaOVPbnVNtojqTGDjUGk7Lceyv0UWlGg83x75An89PH-vXdPP-8rZebVLNWRnSnAtNGFFgGPCiGoTAZVYyUWTbgtGCGJYzWmnMNS81wRVTykBJREaxBkPZAt1Pvr2z3xF8kG3tNTSN6sBGL0vBSzIYjeRyIrWz3juoZO_qVrkfSbAcQ5WnUOUU6nBxd_SO2xbMH39KcQAeJsDG_l-3X57ohfw</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Khaykin, Yaariv</creator><creator>Exner, Derek</creator><creator>Birnie, David</creator><creator>Sapp, John</creator><creator>Aggarwal, Sandeep</creator><creator>Sambelashvili, Aleksandre</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Adjusting the timing of left-ventricular pacing using electrocardiogram and device electrograms</title><author>Khaykin, Yaariv ; Exner, Derek ; Birnie, David ; Sapp, John ; Aggarwal, Sandeep ; Sambelashvili, Aleksandre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-649c131aed3e47f1ae908583975b73271d3632fc04c48c10f3aade819520ced23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Atrioventricular Block - physiopathology</topic><topic>Atrioventricular Block - therapy</topic><topic>Atrioventricular Node - physiopathology</topic><topic>Bundle-Branch Block - physiopathology</topic><topic>Bundle-Branch Block - therapy</topic><topic>Cardiac Resynchronization Therapy - methods</topic><topic>Cardiac Resynchronization Therapy Devices</topic><topic>Electrocardiography - methods</topic><topic>Electrophysiologic Techniques, Cardiac - methods</topic><topic>Female</topic><topic>Heart Conduction System - physiopathology</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Stroke Volume - physiology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khaykin, Yaariv</creatorcontrib><creatorcontrib>Exner, Derek</creatorcontrib><creatorcontrib>Birnie, David</creatorcontrib><creatorcontrib>Sapp, John</creatorcontrib><creatorcontrib>Aggarwal, Sandeep</creatorcontrib><creatorcontrib>Sambelashvili, Aleksandre</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Europace (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Khaykin, Yaariv</au><au>Exner, Derek</au><au>Birnie, David</au><au>Sapp, John</au><au>Aggarwal, Sandeep</au><au>Sambelashvili, Aleksandre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adjusting the timing of left-ventricular pacing using electrocardiogram and device electrograms</atitle><jtitle>Europace (London, England)</jtitle><addtitle>Europace</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>13</volume><issue>10</issue><spage>1464</spage><epage>1470</epage><pages>1464-1470</pages><issn>1099-5129</issn><eissn>1532-2092</eissn><abstract>Aims
Left-ventricular (LV) pacing with optimized atrio-ventricular (AV) timing may provide similar or greater benefit in comparison with bi-ventricular (BiV) pacing in a subset of cardiac resynchronization therapy (CRT) patients with sinus rhythm and preserved AV conduction. We hypothesized that the optimal device AV delays during LV pacing can be predicted using electrocardiogram (ECG) and device electrograms.
Methods and results
Patients (n= 55) with sinus rhythm and PR interval < 300 ms had their CRT devices programmed to atrial and LV pacing with a range of AVs as well as to echocardiographically optimized BiV and no ventricular pacing. At each setting, LV function was evaluated using echocardiography and AVs corresponding to the highest LV ejection fraction (LVEF), lowest LV end-systolic volume (LVESV), and the average of the two (by EF and ESV) were determined. Correlation between the optimal AVs and the following intervals was investigated: intrinsic QRS duration (QRSs), intervals from atrial pacing (Ap) to right-ventricular (RV) sensing (Ap-RVs), from RV sensing to LV activation (RVs-LVs), and from LV pacing to RV sensing (LVp-RVs). Optimal AVs moderately correlated with intrinsic Ap-RVs interval, whereas other parameters showed weak or no correlation. The best correlation (R = 0.66, P< 0.0001) was between the optimal AV delay according to EF and ESV, and Ap-RVs interval. Programming of AVs during LV pacing to the shortest of 70% of the intrinsic Ap-RVs interval, or Ap-RVs-40 ms resulted in significant improvement in LV function similar to that in case of BiV.
Conclusion
Optimal AV during LV pacing can be approximated from the intrinsic AV conduction time.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>21596719</pmid><doi>10.1093/europace/eur146</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Atrioventricular Block - physiopathology Atrioventricular Block - therapy Atrioventricular Node - physiopathology Bundle-Branch Block - physiopathology Bundle-Branch Block - therapy Cardiac Resynchronization Therapy - methods Cardiac Resynchronization Therapy Devices Electrocardiography - methods Electrophysiologic Techniques, Cardiac - methods Female Heart Conduction System - physiopathology Heart Ventricles - physiopathology Humans Male Middle Aged Predictive Value of Tests Stroke Volume - physiology Treatment Outcome |
title | Adjusting the timing of left-ventricular pacing using electrocardiogram and device electrograms |
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