Triggering of TNFRSF25 promotes CD8+ T‐cell responses and anti‐tumor immunity

TNFRSF25 is a member of the TNF receptor superfamily (TNFRSF) that binds to the TNF‐like protein TL1A. Although recent studies have demonstrated a role for TNFRSF25 in regulating CD4+ T‐cell responses, it remains to be determined if TNFRSF25 functions as a costimulatory receptor for CD8+ T cells. He...

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Veröffentlicht in:	European journal of immunology 2011-09, Vol.41 (9), p.2606-2611
Hauptverfasser:	Slebioda, Tomasz J., Rowley, Tania F., Ferdinand, John R., Willoughby, Jane E., Buchan, Sarah L., Taraban, Vadim Y., Al‐Shamkhani, Aymen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - immunology Cancer Vaccines CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cell Line, Tumor Cell Proliferation Costimulation CTL Cytotoxicity, Immunologic Death receptor 3 Humans Immunologic Memory Lymphocyte Activation Lymphocytes Medical research Mice Mice, Inbred C57BL Mice, Transgenic Plasmacytoma - immunology Plasmacytoma - metabolism Plasmacytoma - pathology Receptors, Tumor Necrosis Factor, Member 25 - immunology Receptors, Tumor Necrosis Factor, Member 25 - metabolism T cell receptors Transgenes - genetics Tumor Necrosis Factor Ligand Superfamily Member 15 - genetics Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism
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