Obesity in Trauma Patients: Correlations of Body Mass Index with Outcomes, Injury Patterns, and Complications

Current understanding of the effects of obesity on trauma patients is incomplete. We hypothesized that among older trauma patients, obese patients differ from nonobese patients in injury patterns, complications, and mortality. Patients older than 45 years old presenting to a Level I trauma center we...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The American surgeon 2011-08, Vol.77 (8), p.1003-1008
Hauptverfasser: EVANS, David C, STAWICKI, Stanislaw P. A, DAVIDO, H. Tracy, EIFERMAN, Daniel
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 1008
container_issue 8
container_start_page 1003
container_title The American surgeon
container_volume 77
creator EVANS, David C
STAWICKI, Stanislaw P. A
DAVIDO, H. Tracy
EIFERMAN, Daniel
description Current understanding of the effects of obesity on trauma patients is incomplete. We hypothesized that among older trauma patients, obese patients differ from nonobese patients in injury patterns, complications, and mortality. Patients older than 45 years old presenting to a Level I trauma center were included in this retrospective database analysis (n = 461). Body mass index (BMI) groups were defined as underweight less than 18.5 kg/m(2), normal 18.5 to 24.9 kg/m(2), overweight 25.0 to 29.9 kg/m(2), or obese greater than 30 kg/m(2). Injury patterns, complications, and outcomes were analyzed using univariate analyses, multivariate logistic regression, and Kaplan-Meier survival analysis. Higher BMI is associated with a higher incidence of torso injury and proximal upper extremity injuries in blunt trauma (n = 410). All other injury patterns and complications (except anemia) were similar between BMI groups. The underweight (BMI less than 18.5 kg/m(2)) group had significantly lower 90-day survival than other groups (P < 0.05). BMI is not a predictor of morbidity or mortality in multivariate analysis. Among older blunt trauma patients, increasing BMI is associated with higher rates of torso and proximal upper extremity injuries. Our study suggests that obesity is not an independent risk factor for complications or mortality after trauma in older patients. Conversely, underweight trauma patients had a lower 90-day survival.
doi_str_mv 10.1177/000313481107700818
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_894812434</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>894812434</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-ce7e6e357de40de96914a98d482a74ed28dd6970545dfec29677488809b31fe43</originalsourceid><addsrcrecordid>eNp9kV1rFDEUhkOxtGv1D3ghQZB60dF8TpLe2UVrobJe1Oshm5zBWWaSNZnB7r9vht1WUOhVOIfnfSDnRegNJR8pVeoTIYRTLjSlRClCNNVHaEGllJXRjL9AixmoZuIUvcx5U0ZRS3qCThk1QkgqFmhYrSF34w53Ad8lOw0W_7BjB2HMl3gZU4K-jDFkHFt8Ff0Of7c545vg4R7_6cZfeDWNLg6QL8pyM6XdnB8hhbKwwRfHsO07t5e8Qset7TO8Prxn6OfXL3fLb9Xt6vpm-fm2coLXY-VAQQ1cKg-CeDC1ocIa7YVmVgnwTHtfG0WkkL4Fx0ytlNBaE7PmtAXBz9D53rtN8fcEeWyGLjvoexsgTrnRplyNCT6TH54lqTaKF7Ge0Xf_oJs4pVD-0WjNayOZUgVie8ilmHOCttmmbrBp11DSzK01_7dWQm8P5mk9gH-KPNZUgPcHwGZn-zbZ4Lr8lxPc1IIz_gB6Rp11</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>883695277</pqid></control><display><type>article</type><title>Obesity in Trauma Patients: Correlations of Body Mass Index with Outcomes, Injury Patterns, and Complications</title><source>SAGE Complete A-Z List</source><source>MEDLINE</source><creator>EVANS, David C ; STAWICKI, Stanislaw P. A ; DAVIDO, H. Tracy ; EIFERMAN, Daniel</creator><creatorcontrib>EVANS, David C ; STAWICKI, Stanislaw P. A ; DAVIDO, H. Tracy ; EIFERMAN, Daniel</creatorcontrib><description>Current understanding of the effects of obesity on trauma patients is incomplete. We hypothesized that among older trauma patients, obese patients differ from nonobese patients in injury patterns, complications, and mortality. Patients older than 45 years old presenting to a Level I trauma center were included in this retrospective database analysis (n = 461). Body mass index (BMI) groups were defined as underweight less than 18.5 kg/m(2), normal 18.5 to 24.9 kg/m(2), overweight 25.0 to 29.9 kg/m(2), or obese greater than 30 kg/m(2). Injury patterns, complications, and outcomes were analyzed using univariate analyses, multivariate logistic regression, and Kaplan-Meier survival analysis. Higher BMI is associated with a higher incidence of torso injury and proximal upper extremity injuries in blunt trauma (n = 410). All other injury patterns and complications (except anemia) were similar between BMI groups. The underweight (BMI less than 18.5 kg/m(2)) group had significantly lower 90-day survival than other groups (P &lt; 0.05). BMI is not a predictor of morbidity or mortality in multivariate analysis. Among older blunt trauma patients, increasing BMI is associated with higher rates of torso and proximal upper extremity injuries. Our study suggests that obesity is not an independent risk factor for complications or mortality after trauma in older patients. Conversely, underweight trauma patients had a lower 90-day survival.</description><identifier>ISSN: 0003-1348</identifier><identifier>EISSN: 1555-9823</identifier><identifier>DOI: 10.1177/000313481107700818</identifier><identifier>PMID: 21944514</identifier><identifier>CODEN: AMSUAW</identifier><language>eng</language><publisher>Atlanta, GA: Southeastern Surgical Congress</publisher><subject>Aged ; Biological and medical sciences ; Body Mass Index ; Clinical outcomes ; Cohort Studies ; Comorbidity ; Female ; Follow-Up Studies ; General aspects ; Hospital Mortality - trends ; Hospitals ; Humans ; Injury Severity Score ; Kaplan-Meier Estimate ; Length of Stay - trends ; Logistic Models ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Mortality ; Multivariate Analysis ; Obesity ; Obesity - diagnosis ; Obesity - epidemiology ; Postoperative Complications - epidemiology ; Postoperative Complications - physiopathology ; Registries ; Retrospective Studies ; Risk Assessment ; Sex Factors ; Trauma ; Trauma Centers ; Treatment Outcome ; Wound Healing - physiology ; Wounds and Injuries - diagnosis ; Wounds and Injuries - epidemiology ; Wounds and Injuries - surgery</subject><ispartof>The American surgeon, 2011-08, Vol.77 (8), p.1003-1008</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright Southeastern Surgical Congress Aug 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-ce7e6e357de40de96914a98d482a74ed28dd6970545dfec29677488809b31fe43</citedby><cites>FETCH-LOGICAL-c436t-ce7e6e357de40de96914a98d482a74ed28dd6970545dfec29677488809b31fe43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=24396432$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21944514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>EVANS, David C</creatorcontrib><creatorcontrib>STAWICKI, Stanislaw P. A</creatorcontrib><creatorcontrib>DAVIDO, H. Tracy</creatorcontrib><creatorcontrib>EIFERMAN, Daniel</creatorcontrib><title>Obesity in Trauma Patients: Correlations of Body Mass Index with Outcomes, Injury Patterns, and Complications</title><title>The American surgeon</title><addtitle>Am Surg</addtitle><description>Current understanding of the effects of obesity on trauma patients is incomplete. We hypothesized that among older trauma patients, obese patients differ from nonobese patients in injury patterns, complications, and mortality. Patients older than 45 years old presenting to a Level I trauma center were included in this retrospective database analysis (n = 461). Body mass index (BMI) groups were defined as underweight less than 18.5 kg/m(2), normal 18.5 to 24.9 kg/m(2), overweight 25.0 to 29.9 kg/m(2), or obese greater than 30 kg/m(2). Injury patterns, complications, and outcomes were analyzed using univariate analyses, multivariate logistic regression, and Kaplan-Meier survival analysis. Higher BMI is associated with a higher incidence of torso injury and proximal upper extremity injuries in blunt trauma (n = 410). All other injury patterns and complications (except anemia) were similar between BMI groups. The underweight (BMI less than 18.5 kg/m(2)) group had significantly lower 90-day survival than other groups (P &lt; 0.05). BMI is not a predictor of morbidity or mortality in multivariate analysis. Among older blunt trauma patients, increasing BMI is associated with higher rates of torso and proximal upper extremity injuries. Our study suggests that obesity is not an independent risk factor for complications or mortality after trauma in older patients. Conversely, underweight trauma patients had a lower 90-day survival.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Clinical outcomes</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Hospital Mortality - trends</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Injury Severity Score</subject><subject>Kaplan-Meier Estimate</subject><subject>Length of Stay - trends</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Obesity</subject><subject>Obesity - diagnosis</subject><subject>Obesity - epidemiology</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - physiopathology</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Sex Factors</subject><subject>Trauma</subject><subject>Trauma Centers</subject><subject>Treatment Outcome</subject><subject>Wound Healing - physiology</subject><subject>Wounds and Injuries - diagnosis</subject><subject>Wounds and Injuries - epidemiology</subject><subject>Wounds and Injuries - surgery</subject><issn>0003-1348</issn><issn>1555-9823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kV1rFDEUhkOxtGv1D3ghQZB60dF8TpLe2UVrobJe1Oshm5zBWWaSNZnB7r9vht1WUOhVOIfnfSDnRegNJR8pVeoTIYRTLjSlRClCNNVHaEGllJXRjL9AixmoZuIUvcx5U0ZRS3qCThk1QkgqFmhYrSF34w53Ad8lOw0W_7BjB2HMl3gZU4K-jDFkHFt8Ff0Of7c545vg4R7_6cZfeDWNLg6QL8pyM6XdnB8hhbKwwRfHsO07t5e8Qset7TO8Prxn6OfXL3fLb9Xt6vpm-fm2coLXY-VAQQ1cKg-CeDC1ocIa7YVmVgnwTHtfG0WkkL4Fx0ytlNBaE7PmtAXBz9D53rtN8fcEeWyGLjvoexsgTrnRplyNCT6TH54lqTaKF7Ge0Xf_oJs4pVD-0WjNayOZUgVie8ilmHOCttmmbrBp11DSzK01_7dWQm8P5mk9gH-KPNZUgPcHwGZn-zbZ4Lr8lxPc1IIz_gB6Rp11</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>EVANS, David C</creator><creator>STAWICKI, Stanislaw P. A</creator><creator>DAVIDO, H. Tracy</creator><creator>EIFERMAN, Daniel</creator><general>Southeastern Surgical Congress</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>Obesity in Trauma Patients: Correlations of Body Mass Index with Outcomes, Injury Patterns, and Complications</title><author>EVANS, David C ; STAWICKI, Stanislaw P. A ; DAVIDO, H. Tracy ; EIFERMAN, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-ce7e6e357de40de96914a98d482a74ed28dd6970545dfec29677488809b31fe43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Clinical outcomes</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Hospital Mortality - trends</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Injury Severity Score</topic><topic>Kaplan-Meier Estimate</topic><topic>Length of Stay - trends</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Multivariate Analysis</topic><topic>Obesity</topic><topic>Obesity - diagnosis</topic><topic>Obesity - epidemiology</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - physiopathology</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Sex Factors</topic><topic>Trauma</topic><topic>Trauma Centers</topic><topic>Treatment Outcome</topic><topic>Wound Healing - physiology</topic><topic>Wounds and Injuries - diagnosis</topic><topic>Wounds and Injuries - epidemiology</topic><topic>Wounds and Injuries - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>EVANS, David C</creatorcontrib><creatorcontrib>STAWICKI, Stanislaw P. A</creatorcontrib><creatorcontrib>DAVIDO, H. Tracy</creatorcontrib><creatorcontrib>EIFERMAN, Daniel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>The American surgeon</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>EVANS, David C</au><au>STAWICKI, Stanislaw P. A</au><au>DAVIDO, H. Tracy</au><au>EIFERMAN, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity in Trauma Patients: Correlations of Body Mass Index with Outcomes, Injury Patterns, and Complications</atitle><jtitle>The American surgeon</jtitle><addtitle>Am Surg</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>77</volume><issue>8</issue><spage>1003</spage><epage>1008</epage><pages>1003-1008</pages><issn>0003-1348</issn><eissn>1555-9823</eissn><coden>AMSUAW</coden><abstract>Current understanding of the effects of obesity on trauma patients is incomplete. We hypothesized that among older trauma patients, obese patients differ from nonobese patients in injury patterns, complications, and mortality. Patients older than 45 years old presenting to a Level I trauma center were included in this retrospective database analysis (n = 461). Body mass index (BMI) groups were defined as underweight less than 18.5 kg/m(2), normal 18.5 to 24.9 kg/m(2), overweight 25.0 to 29.9 kg/m(2), or obese greater than 30 kg/m(2). Injury patterns, complications, and outcomes were analyzed using univariate analyses, multivariate logistic regression, and Kaplan-Meier survival analysis. Higher BMI is associated with a higher incidence of torso injury and proximal upper extremity injuries in blunt trauma (n = 410). All other injury patterns and complications (except anemia) were similar between BMI groups. The underweight (BMI less than 18.5 kg/m(2)) group had significantly lower 90-day survival than other groups (P &lt; 0.05). BMI is not a predictor of morbidity or mortality in multivariate analysis. Among older blunt trauma patients, increasing BMI is associated with higher rates of torso and proximal upper extremity injuries. Our study suggests that obesity is not an independent risk factor for complications or mortality after trauma in older patients. Conversely, underweight trauma patients had a lower 90-day survival.</abstract><cop>Atlanta, GA</cop><pub>Southeastern Surgical Congress</pub><pmid>21944514</pmid><doi>10.1177/000313481107700818</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0003-1348
ispartof The American surgeon, 2011-08, Vol.77 (8), p.1003-1008
issn 0003-1348
1555-9823
language eng
recordid cdi_proquest_miscellaneous_894812434
source SAGE Complete A-Z List; MEDLINE
subjects Aged
Biological and medical sciences
Body Mass Index
Clinical outcomes
Cohort Studies
Comorbidity
Female
Follow-Up Studies
General aspects
Hospital Mortality - trends
Hospitals
Humans
Injury Severity Score
Kaplan-Meier Estimate
Length of Stay - trends
Logistic Models
Male
Medical sciences
Metabolic diseases
Middle Aged
Mortality
Multivariate Analysis
Obesity
Obesity - diagnosis
Obesity - epidemiology
Postoperative Complications - epidemiology
Postoperative Complications - physiopathology
Registries
Retrospective Studies
Risk Assessment
Sex Factors
Trauma
Trauma Centers
Treatment Outcome
Wound Healing - physiology
Wounds and Injuries - diagnosis
Wounds and Injuries - epidemiology
Wounds and Injuries - surgery
title Obesity in Trauma Patients: Correlations of Body Mass Index with Outcomes, Injury Patterns, and Complications
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T00%3A20%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Obesity%20in%20Trauma%20Patients:%20Correlations%20of%20Body%20Mass%20Index%20with%20Outcomes,%20Injury%20Patterns,%20and%20Complications&rft.jtitle=The%20American%20surgeon&rft.au=EVANS,%20David%20C&rft.date=2011-08-01&rft.volume=77&rft.issue=8&rft.spage=1003&rft.epage=1008&rft.pages=1003-1008&rft.issn=0003-1348&rft.eissn=1555-9823&rft.coden=AMSUAW&rft_id=info:doi/10.1177/000313481107700818&rft_dat=%3Cproquest_cross%3E894812434%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=883695277&rft_id=info:pmid/21944514&rfr_iscdi=true