Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis
We retrospectively compared the outcomes of 225 patients with adult acquired aplastic anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and those treated by alloHSCT from alternative donors (ADs). Univariate and multivariate a...
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| Veröffentlicht in: | Biology of blood and marrow transplantation 2011-09, Vol.17 (9), p.1289-1298 |
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| creator | Kim, Hawk Kim, Byung Soo Kim, Dong Hwan Hyun, Myung Soo Kim, Sung Hyun Bae, Sung Hwa Choi, Jung Hye Sohn, Sang Kyun Shin, Ho Jin Won, Jong Ho Yoon, Sung-Soo Jo, Deog-Yoen Joo, Young Don Park, Jae-Hoo Lee, Kyoo-Hyung |
| description | We retrospectively compared the outcomes of 225 patients with adult acquired aplastic anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and those treated by alloHSCT from alternative donors (ADs). Univariate and multivariate analyses of factors associated with survival were performed. Multivariate analysis showed that age at alloHSCT of ≤31 years, MRD, successful engraftment, absence of acute graft-versus-host disease (aGVHD), and platelet engraftment at ≤21 days, were independent predictors of longer survival. In addition, time to aGVHD and cumulative nonrelapse mortality (NRM) were better in MRD than in AD recipients. Using propensity score matching (PSM), we performed a case-control study comparing 25 patients in each group who underwent alloHSCT from MRDs and ADs. Pretransplantation clinical factors were well balanced in either group. Median survival time was similar, and no statistically significant difference in transplantation outcomes was apparent when MRD and AD recipients were compared. In conclusion, our results suggest that alloHSCT from an AD should be considered earlier in adult patients with AA who do not have an MRD. |
| doi_str_mv | 10.1016/j.bbmt.2010.12.715 |
| format | Article |
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Univariate and multivariate analyses of factors associated with survival were performed. Multivariate analysis showed that age at alloHSCT of ≤31 years, MRD, successful engraftment, absence of acute graft-versus-host disease (aGVHD), and platelet engraftment at ≤21 days, were independent predictors of longer survival. In addition, time to aGVHD and cumulative nonrelapse mortality (NRM) were better in MRD than in AD recipients. Using propensity score matching (PSM), we performed a case-control study comparing 25 patients in each group who underwent alloHSCT from MRDs and ADs. Pretransplantation clinical factors were well balanced in either group. Median survival time was similar, and no statistically significant difference in transplantation outcomes was apparent when MRD and AD recipients were compared. In conclusion, our results suggest that alloHSCT from an AD should be considered earlier in adult patients with AA who do not have an MRD.</description><identifier>ISSN: 1083-8791</identifier><identifier>EISSN: 1523-6536</identifier><identifier>DOI: 10.1016/j.bbmt.2010.12.715</identifier><identifier>PMID: 21220035</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Alternative donor ; Anemia, Aplastic - mortality ; Anemia, Aplastic - therapy ; Aplastic anemia ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Hematology, Oncology and Palliative Medicine ; Hematopoietic stem cell transplantation ; Hematopoietic Stem Cell Transplantation - methods ; Hematopoietic Stem Cell Transplantation - standards ; Hematopoietic Stem Cells - immunology ; Humans ; Male ; Matched related donor ; Middle Aged ; Multivariate Analysis ; Practice Guidelines as Topic ; Retrospective Studies ; Survival Rate ; Tissue Donors ; Transplantation, Homologous ; Treatment Outcome ; Young Adult</subject><ispartof>Biology of blood and marrow transplantation, 2011-09, Vol.17 (9), p.1289-1298</ispartof><rights>American Society for Blood and Marrow Transplantation</rights><rights>2011 American Society for Blood and Marrow Transplantation</rights><rights>Copyright © 2011 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-ebe8c9887c1053932bc0e5a2e6df03de32e9cede08aa009b7002a7ea74f8b9d43</citedby><cites>FETCH-LOGICAL-c454t-ebe8c9887c1053932bc0e5a2e6df03de32e9cede08aa009b7002a7ea74f8b9d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbmt.2010.12.715$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21220035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hawk</creatorcontrib><creatorcontrib>Kim, Byung Soo</creatorcontrib><creatorcontrib>Kim, Dong Hwan</creatorcontrib><creatorcontrib>Hyun, Myung Soo</creatorcontrib><creatorcontrib>Kim, Sung Hyun</creatorcontrib><creatorcontrib>Bae, Sung Hwa</creatorcontrib><creatorcontrib>Choi, Jung Hye</creatorcontrib><creatorcontrib>Sohn, Sang Kyun</creatorcontrib><creatorcontrib>Shin, Ho Jin</creatorcontrib><creatorcontrib>Won, Jong Ho</creatorcontrib><creatorcontrib>Yoon, Sung-Soo</creatorcontrib><creatorcontrib>Jo, Deog-Yoen</creatorcontrib><creatorcontrib>Joo, Young Don</creatorcontrib><creatorcontrib>Park, Jae-Hoo</creatorcontrib><creatorcontrib>Lee, Kyoo-Hyung</creatorcontrib><creatorcontrib>The Korean Society of Blood and Marrow Transplantation</creatorcontrib><creatorcontrib>Korean Society of Blood and Marrow Transplantation</creatorcontrib><title>Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis</title><title>Biology of blood and marrow transplantation</title><addtitle>Biol Blood Marrow Transplant</addtitle><description>We retrospectively compared the outcomes of 225 patients with adult acquired aplastic anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and those treated by alloHSCT from alternative donors (ADs). Univariate and multivariate analyses of factors associated with survival were performed. Multivariate analysis showed that age at alloHSCT of ≤31 years, MRD, successful engraftment, absence of acute graft-versus-host disease (aGVHD), and platelet engraftment at ≤21 days, were independent predictors of longer survival. In addition, time to aGVHD and cumulative nonrelapse mortality (NRM) were better in MRD than in AD recipients. Using propensity score matching (PSM), we performed a case-control study comparing 25 patients in each group who underwent alloHSCT from MRDs and ADs. Pretransplantation clinical factors were well balanced in either group. Median survival time was similar, and no statistically significant difference in transplantation outcomes was apparent when MRD and AD recipients were compared. In conclusion, our results suggest that alloHSCT from an AD should be considered earlier in adult patients with AA who do not have an MRD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Alternative donor</subject><subject>Anemia, Aplastic - mortality</subject><subject>Anemia, Aplastic - therapy</subject><subject>Aplastic anemia</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hematopoietic stem cell transplantation</subject><subject>Hematopoietic Stem Cell Transplantation - methods</subject><subject>Hematopoietic Stem Cell Transplantation - standards</subject><subject>Hematopoietic Stem Cells - immunology</subject><subject>Humans</subject><subject>Male</subject><subject>Matched related donor</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Practice Guidelines as Topic</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tissue Donors</subject><subject>Transplantation, Homologous</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1083-8791</issn><issn>1523-6536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UstuFDEQHCEQCYEf4IB84zSLH_NECGm0PIKUiIgNZ8vj6SVePPbE9my038kP0cMmHDhwartVXaruqix7yeiKUVa92a36fkwrTpcGX9WsfJSdspKLvCpF9RjftBF5U7fsJHsW445SWhdN-zQ74YxzSkV5mv1a-3FSwUTvSA_pDsCRS5X0DQzkG1iVsCo3kM4mCE4lswfywTsfIvFb7Fr_AxwYTc5hVMlP3kDC3ybBSNZgbSTXQbk4WeUWKuOSJ90w20SukAxciuTOpBvS6dvZBER0CI0LRedgNOotuUSw2aNE1PJHylXwE7ho0oFstA-QP-jtnLKHaOLz7MlW2Qgv7utZ9v3Tx-v1eX7x9fOXdXeR66IsUg49NLptmlozWopW8F5TKBWHathSMYDg0GoYgDZKUdr2NaVc1aDqYtv07VCIs-z1kXcK_naGmORoosallQM_R9m0RcVFyRgi-RGpg48xwFZOwYwqHCSjcvFS7uTipVy8lIxL9BKHXt3Tz_0Iw9-RB_MQ8O4IAFxybyDIqPGkqBkvqZMcvPk___t_xrU1zmhlf8IB4s7PaLiNksnIJZWbJU1LmBjDIFFRid-Y08qS</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Kim, Hawk</creator><creator>Kim, Byung Soo</creator><creator>Kim, Dong Hwan</creator><creator>Hyun, Myung Soo</creator><creator>Kim, Sung Hyun</creator><creator>Bae, Sung Hwa</creator><creator>Choi, Jung Hye</creator><creator>Sohn, Sang Kyun</creator><creator>Shin, Ho Jin</creator><creator>Won, Jong Ho</creator><creator>Yoon, Sung-Soo</creator><creator>Jo, Deog-Yoen</creator><creator>Joo, Young Don</creator><creator>Park, Jae-Hoo</creator><creator>Lee, Kyoo-Hyung</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis</title><author>Kim, Hawk ; Kim, Byung Soo ; Kim, Dong Hwan ; Hyun, Myung Soo ; Kim, Sung Hyun ; Bae, Sung Hwa ; Choi, Jung Hye ; Sohn, Sang Kyun ; Shin, Ho Jin ; Won, Jong Ho ; Yoon, Sung-Soo ; Jo, Deog-Yoen ; Joo, Young Don ; Park, Jae-Hoo ; Lee, Kyoo-Hyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-ebe8c9887c1053932bc0e5a2e6df03de32e9cede08aa009b7002a7ea74f8b9d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Alternative donor</topic><topic>Anemia, Aplastic - mortality</topic><topic>Anemia, Aplastic - therapy</topic><topic>Aplastic anemia</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hematopoietic stem cell transplantation</topic><topic>Hematopoietic Stem Cell Transplantation - methods</topic><topic>Hematopoietic Stem Cell Transplantation - standards</topic><topic>Hematopoietic Stem Cells - immunology</topic><topic>Humans</topic><topic>Male</topic><topic>Matched related donor</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Practice Guidelines as Topic</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tissue Donors</topic><topic>Transplantation, Homologous</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hawk</creatorcontrib><creatorcontrib>Kim, Byung Soo</creatorcontrib><creatorcontrib>Kim, Dong Hwan</creatorcontrib><creatorcontrib>Hyun, Myung Soo</creatorcontrib><creatorcontrib>Kim, Sung Hyun</creatorcontrib><creatorcontrib>Bae, Sung Hwa</creatorcontrib><creatorcontrib>Choi, Jung Hye</creatorcontrib><creatorcontrib>Sohn, Sang Kyun</creatorcontrib><creatorcontrib>Shin, Ho Jin</creatorcontrib><creatorcontrib>Won, Jong Ho</creatorcontrib><creatorcontrib>Yoon, Sung-Soo</creatorcontrib><creatorcontrib>Jo, Deog-Yoen</creatorcontrib><creatorcontrib>Joo, Young Don</creatorcontrib><creatorcontrib>Park, Jae-Hoo</creatorcontrib><creatorcontrib>Lee, Kyoo-Hyung</creatorcontrib><creatorcontrib>The Korean Society of Blood and Marrow Transplantation</creatorcontrib><creatorcontrib>Korean Society of Blood and Marrow Transplantation</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of blood and marrow transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hawk</au><au>Kim, Byung Soo</au><au>Kim, Dong Hwan</au><au>Hyun, Myung Soo</au><au>Kim, Sung Hyun</au><au>Bae, Sung Hwa</au><au>Choi, Jung Hye</au><au>Sohn, Sang Kyun</au><au>Shin, Ho Jin</au><au>Won, Jong Ho</au><au>Yoon, Sung-Soo</au><au>Jo, Deog-Yoen</au><au>Joo, Young Don</au><au>Park, Jae-Hoo</au><au>Lee, Kyoo-Hyung</au><aucorp>The Korean Society of Blood and Marrow Transplantation</aucorp><aucorp>Korean Society of Blood and Marrow Transplantation</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis</atitle><jtitle>Biology of blood and marrow transplantation</jtitle><addtitle>Biol Blood Marrow Transplant</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>17</volume><issue>9</issue><spage>1289</spage><epage>1298</epage><pages>1289-1298</pages><issn>1083-8791</issn><eissn>1523-6536</eissn><abstract>We retrospectively compared the outcomes of 225 patients with adult acquired aplastic anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and those treated by alloHSCT from alternative donors (ADs). Univariate and multivariate analyses of factors associated with survival were performed. Multivariate analysis showed that age at alloHSCT of ≤31 years, MRD, successful engraftment, absence of acute graft-versus-host disease (aGVHD), and platelet engraftment at ≤21 days, were independent predictors of longer survival. In addition, time to aGVHD and cumulative nonrelapse mortality (NRM) were better in MRD than in AD recipients. Using propensity score matching (PSM), we performed a case-control study comparing 25 patients in each group who underwent alloHSCT from MRDs and ADs. Pretransplantation clinical factors were well balanced in either group. Median survival time was similar, and no statistically significant difference in transplantation outcomes was apparent when MRD and AD recipients were compared. In conclusion, our results suggest that alloHSCT from an AD should be considered earlier in adult patients with AA who do not have an MRD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21220035</pmid><doi>10.1016/j.bbmt.2010.12.715</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1083-8791 |
| ispartof | Biology of blood and marrow transplantation, 2011-09, Vol.17 (9), p.1289-1298 |
| issn | 1083-8791 1523-6536 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Alternative donor Anemia, Aplastic - mortality Anemia, Aplastic - therapy Aplastic anemia Case-Control Studies Child Child, Preschool Female Hematology, Oncology and Palliative Medicine Hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cell Transplantation - standards Hematopoietic Stem Cells - immunology Humans Male Matched related donor Middle Aged Multivariate Analysis Practice Guidelines as Topic Retrospective Studies Survival Rate Tissue Donors Transplantation, Homologous Treatment Outcome Young Adult |
| title | Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis |
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