Antimalarial β-Carbolines from the New Zealand Ascidian Pseudodistoma opacum

One tetrahydro-β-carboline, (−)-7-bromohomotrypargine (1), and three alkylguanidine-substituted β-carbolines, opacalines A, B, and C (2–4), have been isolated from the New Zealand ascidian Pseudodistoma opacum. The structures of the metabolites were determined by analysis of mass spectrometric and 2...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2011-09, Vol.74 (9), p.1972-1979
Hauptverfasser:	Chan, Susanna T. S, Pearce, A. Norrie, Page, Michael J, Kaiser, Marcel, Copp, Brent R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - chemistry Antimalarials - isolation & purification Antimalarials - pharmacology Biological and medical sciences Carbolines - chemistry Carbolines - isolation & purification Carbolines - pharmacology Chloroquine - pharmacology Drug Resistance - drug effects General pharmacology Marine Medical sciences Molecular Structure New Zealand Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - drug effects Stereoisomerism Urochordata - chemistry
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