Discovering pluripotency: 30 years of mouse embryonic stem cells
This year marks the thirtieth anniversary since embryonic stem (ES) cells were first isolated from mouse blastocysts. In this Timeline, one of the scientists to isolate mouse ES cells in 1981 gives a personal account of the ideas that led to, and followed, this milestone. Embryonic stem (ES) cells a...
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| Veröffentlicht in: | Nature reviews. Molecular cell biology 2011-10, Vol.12 (10), p.680-686 |
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| description | This year marks the thirtieth anniversary since embryonic stem (ES) cells were first isolated from mouse blastocysts. In this Timeline, one of the scientists to isolate mouse ES cells in 1981 gives a personal account of the ideas that led to, and followed, this milestone.
Embryonic stem (ES) cells are pluripotent cells isolated from an early embryo and grown as a cell line in tissue culture. Their discovery came from the conjunction of studies in human pathology, mouse genetics, early mouse embryo development, cell surface immunology and tissue culture. ES cells provided a crucial tool for manipulating mouse embryos to study mouse genetics, development and physiology. They have not only revolutionized experimental mammalian genetics but, with the advent of equivalent human ES cells, have now opened new vistas for regenerative medicine. |
| doi_str_mv | 10.1038/nrm3190 |
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Embryonic stem (ES) cells are pluripotent cells isolated from an early embryo and grown as a cell line in tissue culture. Their discovery came from the conjunction of studies in human pathology, mouse genetics, early mouse embryo development, cell surface immunology and tissue culture. ES cells provided a crucial tool for manipulating mouse embryos to study mouse genetics, development and physiology. They have not only revolutionized experimental mammalian genetics but, with the advent of equivalent human ES cells, have now opened new vistas for regenerative medicine.</description><identifier>ISSN: 1471-0072</identifier><identifier>EISSN: 1471-0080</identifier><identifier>DOI: 10.1038/nrm3190</identifier><identifier>PMID: 21941277</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/136/2444 ; 631/532/2064/2117 ; 67 ; 692/308/2171 ; 83 ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Cancer Research ; Care and treatment ; Cell Biology ; Cell culture ; Developmental Biology ; Embryo, Mammalian - cytology ; Embryo, Mammalian - metabolism ; Embryonic stem cells ; Embryonic Stem Cells - cytology ; Embryonic Stem Cells - metabolism ; Embryos ; Genetic aspects ; Genetics ; Histology ; Immunology ; Life Sciences ; Mammals ; Mice ; Ovarian cancer ; Pathology ; Physiological aspects ; Physiology ; Regenerative Medicine - methods ; Stem Cells ; timeline ; Transplants & implants ; Tumors</subject><ispartof>Nature reviews. Molecular cell biology, 2011-10, Vol.12 (10), p.680-686</ispartof><rights>Springer Nature Limited 2011</rights><rights>COPYRIGHT 2011 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Oct 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-4805601c0d4337c78364151246d72ba7829c9b74f170618bd361875ffe604b7b3</citedby><cites>FETCH-LOGICAL-c562t-4805601c0d4337c78364151246d72ba7829c9b74f170618bd361875ffe604b7b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nrm3190$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nrm3190$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21941277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Evans, Martin</creatorcontrib><title>Discovering pluripotency: 30 years of mouse embryonic stem cells</title><title>Nature reviews. Molecular cell biology</title><addtitle>Nat Rev Mol Cell Biol</addtitle><addtitle>Nat Rev Mol Cell Biol</addtitle><description>This year marks the thirtieth anniversary since embryonic stem (ES) cells were first isolated from mouse blastocysts. In this Timeline, one of the scientists to isolate mouse ES cells in 1981 gives a personal account of the ideas that led to, and followed, this milestone.
Embryonic stem (ES) cells are pluripotent cells isolated from an early embryo and grown as a cell line in tissue culture. Their discovery came from the conjunction of studies in human pathology, mouse genetics, early mouse embryo development, cell surface immunology and tissue culture. ES cells provided a crucial tool for manipulating mouse embryos to study mouse genetics, development and physiology. They have not only revolutionized experimental mammalian genetics but, with the advent of equivalent human ES cells, have now opened new vistas for regenerative medicine.</description><subject>631/136/2444</subject><subject>631/532/2064/2117</subject><subject>67</subject><subject>692/308/2171</subject><subject>83</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer Research</subject><subject>Care and treatment</subject><subject>Cell Biology</subject><subject>Cell culture</subject><subject>Developmental Biology</subject><subject>Embryo, Mammalian - cytology</subject><subject>Embryo, Mammalian - metabolism</subject><subject>Embryonic stem cells</subject><subject>Embryonic Stem Cells - cytology</subject><subject>Embryonic Stem Cells - metabolism</subject><subject>Embryos</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>Histology</subject><subject>Immunology</subject><subject>Life Sciences</subject><subject>Mammals</subject><subject>Mice</subject><subject>Ovarian cancer</subject><subject>Pathology</subject><subject>Physiological aspects</subject><subject>Physiology</subject><subject>Regenerative Medicine - 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Molecular cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Evans, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discovering pluripotency: 30 years of mouse embryonic stem cells</atitle><jtitle>Nature reviews. Molecular cell biology</jtitle><stitle>Nat Rev Mol Cell Biol</stitle><addtitle>Nat Rev Mol Cell Biol</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>12</volume><issue>10</issue><spage>680</spage><epage>686</epage><pages>680-686</pages><issn>1471-0072</issn><eissn>1471-0080</eissn><abstract>This year marks the thirtieth anniversary since embryonic stem (ES) cells were first isolated from mouse blastocysts. In this Timeline, one of the scientists to isolate mouse ES cells in 1981 gives a personal account of the ideas that led to, and followed, this milestone.
Embryonic stem (ES) cells are pluripotent cells isolated from an early embryo and grown as a cell line in tissue culture. Their discovery came from the conjunction of studies in human pathology, mouse genetics, early mouse embryo development, cell surface immunology and tissue culture. ES cells provided a crucial tool for manipulating mouse embryos to study mouse genetics, development and physiology. They have not only revolutionized experimental mammalian genetics but, with the advent of equivalent human ES cells, have now opened new vistas for regenerative medicine.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21941277</pmid><doi>10.1038/nrm3190</doi><tpages>7</tpages></addata></record> |
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| subjects | 631/136/2444 631/532/2064/2117 67 692/308/2171 83 Animals Biochemistry Biomedical and Life Sciences Cancer Research Care and treatment Cell Biology Cell culture Developmental Biology Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Embryos Genetic aspects Genetics Histology Immunology Life Sciences Mammals Mice Ovarian cancer Pathology Physiological aspects Physiology Regenerative Medicine - methods Stem Cells timeline Transplants & implants Tumors |
| title | Discovering pluripotency: 30 years of mouse embryonic stem cells |
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