Deficiency in Interferon-γ Results in Reduced Body Weight and Better Glucose Tolerance in Mice

Obesity is a chronic low-grade inflammatory disease caused by increased energy intake and reduced energy expenditure. Studies using animal models with deletion of inflammatory cytokines have produced conflicting results with some showing increased weight gain and others showing no effect or even red...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2011-10, Vol.152 (10), p.3690-3699
Hauptverfasser:	Wong, Nicole, Fam, Barbara C, Cempako, Gitta R, Steinberg, Gregory R, Walder, Ken, Kay, Thomas W, Proietto, Joseph, Andrikopoulos, Sofianos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Arcuate nucleus Biological and medical sciences Body Weight Body weight gain Clamps Cytokines Deletion Energy balance Energy expenditure Energy intake Energy metabolism Food intake Fundamental and applied biological sciences. Psychology Gene expression Gluconeogenesis Glucose Glucose - metabolism Glucose tolerance Glucose-6-phosphatase Inflammatory diseases Insulin Interferon Interferon-gamma - physiology Leptin Liver Liver - metabolism Liver Glycogen - metabolism Low fat diet Male Metabolism Mice Mice, Inbred C57BL Neuropeptide Y Neuropeptides Nutrient deficiency Peptides Physical activity Proopiomelanocortin Sensitivity Vertebrates: endocrinology γ-Interferon
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