Comparison of pregnancy outcome among nulliparas with and without microalbuminuria at the end of the second trimester
Abstract Objective To evaluate the rate of poor pregnancy outcome among nulliparas who had microalbuminuria at the end of the second trimester of their pregnancy. Methods A prospective cohort study was performed on 490 nulliparous women who were at the end of the second trimester of pregnancy. Urine...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2011-10, Vol.115 (1), p.34-36 |
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| description | Abstract Objective To evaluate the rate of poor pregnancy outcome among nulliparas who had microalbuminuria at the end of the second trimester of their pregnancy. Methods A prospective cohort study was performed on 490 nulliparous women who were at the end of the second trimester of pregnancy. Urine tests for albuminuria and creatinine measurements were performed in all women and the albumin to creatinine ratio (ACR) was calculated. The women with microalbuminuria (exposed group) and those without microalbuminuria (nonexposed group) were monitored until the end of their pregnancy and compared for pregnancy outcome. Results Preterm labor (57.9% versus 13.5%), preeclampsia (50.0% versus 8.6%), intrauterine growth restriction (42.1% versus 6.4%), and preterm premature rupture of membranes (31.6% versus 10.2%) were significantly more common in the exposed group. The rates of gestational diabetes did not differ significantly between the 2 groups. In multivariate logistic regression analyses, microalbuminuria increased the risks for preterm labor (adjusted OR 2.4; 95% CI 1.1–5.5, P = 0.03) and preeclampsia (adjusted OR 9.5; 95% CI 4.6–19.3, P < 0.001). Conclusion Microalbuminuria at the end of the second trimester of pregnancy might increase the risks of preterm labor, preeclampsia, intrauterine growth restriction, and preterm premature rupture of membranes. |
| doi_str_mv | 10.1016/j.ijgo.2011.04.012 |
| format | Article |
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Methods A prospective cohort study was performed on 490 nulliparous women who were at the end of the second trimester of pregnancy. Urine tests for albuminuria and creatinine measurements were performed in all women and the albumin to creatinine ratio (ACR) was calculated. The women with microalbuminuria (exposed group) and those without microalbuminuria (nonexposed group) were monitored until the end of their pregnancy and compared for pregnancy outcome. Results Preterm labor (57.9% versus 13.5%), preeclampsia (50.0% versus 8.6%), intrauterine growth restriction (42.1% versus 6.4%), and preterm premature rupture of membranes (31.6% versus 10.2%) were significantly more common in the exposed group. The rates of gestational diabetes did not differ significantly between the 2 groups. In multivariate logistic regression analyses, microalbuminuria increased the risks for preterm labor (adjusted OR 2.4; 95% CI 1.1–5.5, P = 0.03) and preeclampsia (adjusted OR 9.5; 95% CI 4.6–19.3, P < 0.001). Conclusion Microalbuminuria at the end of the second trimester of pregnancy might increase the risks of preterm labor, preeclampsia, intrauterine growth restriction, and preterm premature rupture of membranes.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/j.ijgo.2011.04.012</identifier><identifier>PMID: 21794863</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ; Albuminuria - complications ; Biological and medical sciences ; Cohort Studies ; Creatinine - urine ; Delivery. Postpartum. Lactation ; Diseases of mother, fetus and pregnancy ; Disorders ; Female ; Fetal Growth Retardation - epidemiology ; Fetal Growth Retardation - etiology ; Fetal Membranes, Premature Rupture - epidemiology ; Fetal Membranes, Premature Rupture - etiology ; Gynecology. Andrology. Obstetrics ; Humans ; Intrauterine growth restriction ; Logistic Models ; Medical sciences ; Microalbuminuria ; Multivariate Analysis ; Nephrology. Urinary tract diseases ; Obstetric Labor, Premature - epidemiology ; Obstetric Labor, Premature - etiology ; Obstetrics and Gynecology ; Pre-Eclampsia - epidemiology ; Pre-Eclampsia - etiology ; Preeclampsia ; Pregnancy ; Pregnancy Complications - epidemiology ; Pregnancy Outcome ; Pregnancy Trimester, Second ; Pregnancy. Fetus. Placenta ; Preterm labor ; Preterm premature rupture of membranes ; Prospective Studies ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland ; Young Adult</subject><ispartof>International journal of gynecology and obstetrics, 2011-10, Vol.115 (1), p.34-36</ispartof><rights>International Federation of Gynecology and Obstetrics</rights><rights>2011 International Federation of Gynecology and Obstetrics</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4874-1165f9e90665abd2a7d8227639b8b22bb1d931b80f49bd0b84ad500378a452f3</citedby><cites>FETCH-LOGICAL-c4874-1165f9e90665abd2a7d8227639b8b22bb1d931b80f49bd0b84ad500378a452f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.ijgo.2011.04.012$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.ijgo.2011.04.012$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24554041$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21794863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bahasadri, Shohreh</creatorcontrib><creatorcontrib>Kashanian, Maryam</creatorcontrib><creatorcontrib>Khosravi, Zahra</creatorcontrib><title>Comparison of pregnancy outcome among nulliparas with and without microalbuminuria at the end of the second trimester</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Abstract Objective To evaluate the rate of poor pregnancy outcome among nulliparas who had microalbuminuria at the end of the second trimester of their pregnancy. Methods A prospective cohort study was performed on 490 nulliparous women who were at the end of the second trimester of pregnancy. Urine tests for albuminuria and creatinine measurements were performed in all women and the albumin to creatinine ratio (ACR) was calculated. The women with microalbuminuria (exposed group) and those without microalbuminuria (nonexposed group) were monitored until the end of their pregnancy and compared for pregnancy outcome. Results Preterm labor (57.9% versus 13.5%), preeclampsia (50.0% versus 8.6%), intrauterine growth restriction (42.1% versus 6.4%), and preterm premature rupture of membranes (31.6% versus 10.2%) were significantly more common in the exposed group. The rates of gestational diabetes did not differ significantly between the 2 groups. In multivariate logistic regression analyses, microalbuminuria increased the risks for preterm labor (adjusted OR 2.4; 95% CI 1.1–5.5, P = 0.03) and preeclampsia (adjusted OR 9.5; 95% CI 4.6–19.3, P < 0.001). Conclusion Microalbuminuria at the end of the second trimester of pregnancy might increase the risks of preterm labor, preeclampsia, intrauterine growth restriction, and preterm premature rupture of membranes.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Albuminuria - complications</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Creatinine - urine</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Disorders</subject><subject>Female</subject><subject>Fetal Growth Retardation - epidemiology</subject><subject>Fetal Growth Retardation - etiology</subject><subject>Fetal Membranes, Premature Rupture - epidemiology</subject><subject>Fetal Membranes, Premature Rupture - etiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Intrauterine growth restriction</subject><subject>Logistic Models</subject><subject>Medical sciences</subject><subject>Microalbuminuria</subject><subject>Multivariate Analysis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Obstetric Labor, Premature - epidemiology</subject><subject>Obstetric Labor, Premature - etiology</subject><subject>Obstetrics and Gynecology</subject><subject>Pre-Eclampsia - epidemiology</subject><subject>Pre-Eclampsia - etiology</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Trimester, Second</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Preterm labor</subject><subject>Preterm premature rupture of membranes</subject><subject>Prospective Studies</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><subject>Young Adult</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNksFu1DAQhiMEotvCC3BAviBOCWPHiWMJIVUrWooq9UDvluNMtg6JvdgJ1b49DruAxAFx8lj6_rH9ebLsFYWCAq3fDYUddr5gQGkBvADKnmQb2giZl1zIp9kGgEEumGRn2XmMAwBQQenz7IxRIXlTl5ts2fppr4ON3hHfk33AndPOHIhfZuMnJHrybkfcMo42cTqSRzs_EO26n0WiyGRN8Hpsl8m6JVhN9EzmBySYmNRyLSMan3ZzsBPGGcOL7Fmvx4gvT-tFdn_18X77Kb-9u77ZXt7mhjeC55TWVS9RQl1Xuu2YFl3DmKhL2TYtY21LO1nStoGey7aDtuG6qwBK0Whesb68yN4e2-6D_7akk9Vko8Fx1A79ElUjS8EY1DKR7Eimp8QYsFf7dFcdDoqCWmWrQa2y1SpbAVdJdgq9PrVf2gm735FfdhPw5gToaPTYh2TWxj8cryoOnCauPnKPdsTDfxytbj5f35U8Bd8fg5gkfrcYVDQWncHOBjSz6rz99wM-_BU3o3U2XfUrHjAOfgkufY-iKjIF6ss6T-s4UZokQwPlD67CxGU</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Bahasadri, Shohreh</creator><creator>Kashanian, Maryam</creator><creator>Khosravi, Zahra</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Comparison of pregnancy outcome among nulliparas with and without microalbuminuria at the end of the second trimester</title><author>Bahasadri, Shohreh ; Kashanian, Maryam ; Khosravi, Zahra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4874-1165f9e90665abd2a7d8227639b8b22bb1d931b80f49bd0b84ad500378a452f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Albuminuria - complications</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Creatinine - urine</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Disorders</topic><topic>Female</topic><topic>Fetal Growth Retardation - epidemiology</topic><topic>Fetal Growth Retardation - etiology</topic><topic>Fetal Membranes, Premature Rupture - epidemiology</topic><topic>Fetal Membranes, Premature Rupture - etiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Intrauterine growth restriction</topic><topic>Logistic Models</topic><topic>Medical sciences</topic><topic>Microalbuminuria</topic><topic>Multivariate Analysis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Obstetric Labor, Premature - epidemiology</topic><topic>Obstetric Labor, Premature - etiology</topic><topic>Obstetrics and Gynecology</topic><topic>Pre-Eclampsia - epidemiology</topic><topic>Pre-Eclampsia - etiology</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Trimester, Second</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Preterm labor</topic><topic>Preterm premature rupture of membranes</topic><topic>Prospective Studies</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bahasadri, Shohreh</creatorcontrib><creatorcontrib>Kashanian, Maryam</creatorcontrib><creatorcontrib>Khosravi, Zahra</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bahasadri, Shohreh</au><au>Kashanian, Maryam</au><au>Khosravi, Zahra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of pregnancy outcome among nulliparas with and without microalbuminuria at the end of the second trimester</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2011-10</date><risdate>2011</risdate><volume>115</volume><issue>1</issue><spage>34</spage><epage>36</epage><pages>34-36</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract>Abstract Objective To evaluate the rate of poor pregnancy outcome among nulliparas who had microalbuminuria at the end of the second trimester of their pregnancy. Methods A prospective cohort study was performed on 490 nulliparous women who were at the end of the second trimester of pregnancy. Urine tests for albuminuria and creatinine measurements were performed in all women and the albumin to creatinine ratio (ACR) was calculated. The women with microalbuminuria (exposed group) and those without microalbuminuria (nonexposed group) were monitored until the end of their pregnancy and compared for pregnancy outcome. Results Preterm labor (57.9% versus 13.5%), preeclampsia (50.0% versus 8.6%), intrauterine growth restriction (42.1% versus 6.4%), and preterm premature rupture of membranes (31.6% versus 10.2%) were significantly more common in the exposed group. The rates of gestational diabetes did not differ significantly between the 2 groups. In multivariate logistic regression analyses, microalbuminuria increased the risks for preterm labor (adjusted OR 2.4; 95% CI 1.1–5.5, P = 0.03) and preeclampsia (adjusted OR 9.5; 95% CI 4.6–19.3, P < 0.001). Conclusion Microalbuminuria at the end of the second trimester of pregnancy might increase the risks of preterm labor, preeclampsia, intrauterine growth restriction, and preterm premature rupture of membranes.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21794863</pmid><doi>10.1016/j.ijgo.2011.04.012</doi><tpages>3</tpages></addata></record> |
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| subjects | Adolescent Adult Albuminuria - complications Biological and medical sciences Cohort Studies Creatinine - urine Delivery. Postpartum. Lactation Diseases of mother, fetus and pregnancy Disorders Female Fetal Growth Retardation - epidemiology Fetal Growth Retardation - etiology Fetal Membranes, Premature Rupture - epidemiology Fetal Membranes, Premature Rupture - etiology Gynecology. Andrology. Obstetrics Humans Intrauterine growth restriction Logistic Models Medical sciences Microalbuminuria Multivariate Analysis Nephrology. Urinary tract diseases Obstetric Labor, Premature - epidemiology Obstetric Labor, Premature - etiology Obstetrics and Gynecology Pre-Eclampsia - epidemiology Pre-Eclampsia - etiology Preeclampsia Pregnancy Pregnancy Complications - epidemiology Pregnancy Outcome Pregnancy Trimester, Second Pregnancy. Fetus. Placenta Preterm labor Preterm premature rupture of membranes Prospective Studies Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Young Adult |
| title | Comparison of pregnancy outcome among nulliparas with and without microalbuminuria at the end of the second trimester |
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