Effects of a glycogen synthase kinase-3β inhibitor (LiCl) on c-myc protein in intervertebral disc cells

Wnt/β‐catenin (hereafter called Wnt) signaling is a key inducer and regulator of joint development, and is involved in the formation of bone and cartilage. We previously reported that Wnt signaling plays an essential role in the control of cell proliferation and cell senescence in intervertebral dis...

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Veröffentlicht in:	Journal of cellular biochemistry 2011-10, Vol.112 (10), p.2974-2986
Hauptverfasser:	Hiyama, Akihiko, Sakai, Daisuke, Arai, Fumiyuki, Nakajima, Daisuke, Yokoyama, Katsuya, Mochida, Joji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - genetics beta Catenin - metabolism Blotting, Western c-myc Cell Cycle - drug effects Cell Cycle - genetics CELL PROLIFERATION Cell Survival - drug effects Cell Survival - genetics Cells, Cultured Female Flow Cytometry Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 beta Immunohistochemistry Intervertebral Disc - cytology Intervertebral Disc - metabolism INTERVERTEBRAL DISC DEGENERATION Lithium Chloride - pharmacology Male NUCLEUS PULPOSUS Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Rats Real-Time Polymerase Chain Reaction Signal Transduction - drug effects Wnt Proteins - genetics Wnt Proteins - metabolism WNT SIGNALING
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