Overview of receptor allosterism

In addition to the orthosteric site, which recognizes endogenous ligands, most G protein-coupled receptors (GPCRs) possess topographically distinct allosteric sites that can be recognized by small molecules and accessory cellular proteins. Ligand binding to allosteric sites promotes a conformational...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Current Protocols in Pharmacology 2010-12, Vol.Chapter 1 (1), p.Unit 1.21-Unit 1.21
Hauptverfasser:	Gregory, Karen J, Sexton, Patrick M, Christopoulos, Arthur
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation - drug effects Allosteric Site - drug effects Animals G-Protein-Coupled Receptor Kinases - antagonists & inhibitors G-Protein-Coupled Receptor Kinases - chemistry G-Protein-Coupled Receptor Kinases - metabolism Humans Kinetics Ligands Models, Biological Molecular Targeted Therapy Signal Transduction - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!