Quantification of 1-(13) C-L-methionine in rat serum with hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry and its application in pharmacokinetic study

A rapid, selective and sensitive hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry (MS/MS) method was developed to determine 1-(13) C-l-methionine in rat serum. Proteins in serum were precipitated using acetonitrile and the supernatant was separated after ce...

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Veröffentlicht in:	Biomedical chromatography 2011-09, Vol.25 (9), p.1025-1029
Hauptverfasser:	Xu, Ying, Huang, Xiao, Nie, Xiuli, Yang, Li, Yan, Weili, Wang, Zhengtao, Wang, Changhong, Hu, Zhibi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Isotopes - analysis Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Male Methionine - blood Methionine - chemistry Methionine - pharmacokinetics Rats Rats, Sprague-Dawley Tandem Mass Spectrometry - methods
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