The response of foetal annulus fibrosus cells to growth factors: modulation of matrix synthesis by TGF-β1 and IGF-1

The annulus fibrosus of the intervertebral disc is a complex radial-ply tissue that derives initially from segmental condensations of axial mesenchyme surrounding the notochord. These mesenchymal condensations differentiate into the early annulus fibrosus during foetal development—their outer part b...

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Veröffentlicht in:	Histochemistry and cell biology 2011-08, Vol.136 (2), p.163-175
Hauptverfasser:	Hayes, Anthony J., Ralphs, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggrecans - biosynthesis Aggrecans - metabolism Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cell Culture Techniques Cells, Cultured - chemistry Collagen Type I - biosynthesis Collagen Type I - metabolism Collagen Type II - biosynthesis Collagen Type II - metabolism Developmental Biology Extracellular Matrix - chemistry Extracellular Matrix - metabolism Fibrocartilage - metabolism Glycosaminoglycans - biosynthesis Glycosaminoglycans - metabolism Insulin-Like Growth Factor I - administration & dosage Insulin-Like Growth Factor I - metabolism Intervertebral Disc - anatomy & histology Intervertebral Disc - cytology Metaplasia Original Paper Proteoglycans - metabolism Rats Rats, Wistar Transforming Growth Factor beta1 - administration & dosage Transforming Growth Factor beta1 - metabolism
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