Semisynthetic analogues of the marine cembranoid sarcophine as prostate and breast cancer migration inhibitors

Sarcophine (1) is a bioactive cembranoid diterpene isolated from the Red Sea soft coral Sarcophyton glaucum. Previous semisynthesis attempts resulted in decreased or complete loss of 1’s anticancer activity. Sarcophine and analogues showed antimigratory activity against breast and prostate cancer ce...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2011-08, Vol.19 (16), p.4928-4934
Hauptverfasser:	Hassan, Hossam M., Sallam, Asmaa A., Mohammed, Rabab, Hifnawy, Mohamed S., Youssef, Diaa T.A., El Sayed, Khalid A.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - chemistry 4-Butyrolactone - pharmacology 4-Butyrolactone - therapeutic use Animals Anthozoa - chemistry anticarcinogenic activity Antimigratory Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biological and medical sciences Breast cancer breast neoplasms Breast Neoplasms - drug therapy Carbamoylation Cell Line, Tumor Cell Migration Assays Cell Migration Inhibition - drug effects Cell Proliferation - drug effects Cembranoids corals Diterpenes - chemical synthesis Diterpenes - chemistry Diterpenes - pharmacology Diterpenes - therapeutic use Drug Screening Assays, Antitumor Etherification Female General aspects Humans Indian Ocean Male Medical sciences metastasis Pharmacology. Drug treatments Prostate cancer prostatic neoplasms Prostatic Neoplasms - drug therapy Sarcophyton Sarcophyton glaucum Semisynthesis Structure-Activity Relationship structure-activity relationships Wound-healing
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