Proteoliposomes from Mycobacterium smegmatis induce immune cross-reactivity against Mycobacterium tuberculosis antigens in mice
Proteoliposomes (PL) obtained from Mycobacterium smegmatis (Ms) were evaluated for their capacity to elicit cross-reactive responses against Mycobacterium tuberculosis (Mtb) antigens in BALB/c mice. Animals immunized with PL adjuvanted with alum (PL–AL) or Freund's Incomplete Adjuvant (PL–IFA)...
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| Veröffentlicht in: | Vaccine 2011-08, Vol.29 (37), p.6236-6241 |
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| creator | Rodriguez, Lissete Tirado, Yanelys Reyes, Fatima Puig, Alina Kadir, Ramlah Borrero, Reinier Fernandez, Sonsire Reyes, Giselle Alvarez, Nadine Garcia, Maria Angeles Sarmiento, Maria Elena Norazmi, Mohd Nor Perez Quinoy, Jose Luis Acosta, Armando |
| description | Proteoliposomes (PL) obtained from Mycobacterium smegmatis (Ms) were evaluated for their capacity to elicit cross-reactive responses against Mycobacterium tuberculosis (Mtb) antigens in BALB/c mice. Animals immunized with PL adjuvanted with alum (PL–AL) or Freund's Incomplete Adjuvant (PL–IFA) showed significant IgG responses against the PL as well as total Ms lipids. Both groups of animals also showed significant IgG responses against BCG, but only animals immunized with PL–AL produced significant IgG responses against soluble cell wall proteins (SCWP) or whole cell lysate (WCL) of Mtb. Significant DTH responses against WCL were observed in both groups of animals after 24h, but only PL–AL-immunized mice showed significant DTH responses after 48h and 72h. PL–Ms are capable of eliciting cross-reactive humoral and cellular responses against Mtb antigens and thus may be a potential vaccine strategy against tuberculosis. |
| doi_str_mv | 10.1016/j.vaccine.2011.06.077 |
| format | Article |
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Animals immunized with PL adjuvanted with alum (PL–AL) or Freund's Incomplete Adjuvant (PL–IFA) showed significant IgG responses against the PL as well as total Ms lipids. Both groups of animals also showed significant IgG responses against BCG, but only animals immunized with PL–AL produced significant IgG responses against soluble cell wall proteins (SCWP) or whole cell lysate (WCL) of Mtb. Significant DTH responses against WCL were observed in both groups of animals after 24h, but only PL–AL-immunized mice showed significant DTH responses after 48h and 72h. PL–Ms are capable of eliciting cross-reactive humoral and cellular responses against Mtb antigens and thus may be a potential vaccine strategy against tuberculosis.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2011.06.077</identifier><identifier>PMID: 21736914</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic ; Advantages ; Allergy and Immunology ; alum ; Alum Compounds - pharmacology ; Animals ; Antibodies, Bacterial - immunology ; Antibody response ; antigens ; Antigens, Bacterial ; Applied microbiology ; Bacteriology ; Bioinformatics ; Biological and medical sciences ; Cell Wall - immunology ; Chromatography ; cross reaction ; Cross Reactions ; Delayed type hypersensitivity ; Female ; Fundamental and applied biological sciences. Psychology ; Immunization ; immunoglobulin G ; Immunoglobulin G - biosynthesis ; Immunoglobulin G - immunology ; Laboratory animals ; Lipids ; M. tuberculosis ; Mice ; Mice, Inbred BALB C ; Microbiology ; Miscellaneous ; Mortality ; Mycobacterium bovis - immunology ; Mycobacterium smegmatis ; Mycobacterium smegmatis - immunology ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - immunology ; Proteins ; Proteolipids - immunology ; Proteoliposomes ; structural proteins ; Transmission electron microscopy ; Tuberculosis ; Tuberculosis - immunology ; Tuberculosis - prevention & control ; Tuberculosis Vaccines ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2011-08, Vol.29 (37), p.6236-6241</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 26, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-b388bd09e2c952bdfbbc3c966316b811ba3c751fc152bad42bae168f40e499093</citedby><cites>FETCH-LOGICAL-c533t-b388bd09e2c952bdfbbc3c966316b811ba3c751fc152bad42bae168f40e499093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X11009510$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24476873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21736914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodriguez, Lissete</creatorcontrib><creatorcontrib>Tirado, Yanelys</creatorcontrib><creatorcontrib>Reyes, Fatima</creatorcontrib><creatorcontrib>Puig, Alina</creatorcontrib><creatorcontrib>Kadir, Ramlah</creatorcontrib><creatorcontrib>Borrero, Reinier</creatorcontrib><creatorcontrib>Fernandez, Sonsire</creatorcontrib><creatorcontrib>Reyes, Giselle</creatorcontrib><creatorcontrib>Alvarez, Nadine</creatorcontrib><creatorcontrib>Garcia, Maria Angeles</creatorcontrib><creatorcontrib>Sarmiento, Maria Elena</creatorcontrib><creatorcontrib>Norazmi, Mohd Nor</creatorcontrib><creatorcontrib>Perez Quinoy, Jose Luis</creatorcontrib><creatorcontrib>Acosta, Armando</creatorcontrib><title>Proteoliposomes from Mycobacterium smegmatis induce immune cross-reactivity against Mycobacterium tuberculosis antigens in mice</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Proteoliposomes (PL) obtained from Mycobacterium smegmatis (Ms) were evaluated for their capacity to elicit cross-reactive responses against Mycobacterium tuberculosis (Mtb) antigens in BALB/c mice. Animals immunized with PL adjuvanted with alum (PL–AL) or Freund's Incomplete Adjuvant (PL–IFA) showed significant IgG responses against the PL as well as total Ms lipids. Both groups of animals also showed significant IgG responses against BCG, but only animals immunized with PL–AL produced significant IgG responses against soluble cell wall proteins (SCWP) or whole cell lysate (WCL) of Mtb. Significant DTH responses against WCL were observed in both groups of animals after 24h, but only PL–AL-immunized mice showed significant DTH responses after 48h and 72h. PL–Ms are capable of eliciting cross-reactive humoral and cellular responses against Mtb antigens and thus may be a potential vaccine strategy against tuberculosis.</description><subject>Adjuvants, Immunologic</subject><subject>Advantages</subject><subject>Allergy and Immunology</subject><subject>alum</subject><subject>Alum Compounds - pharmacology</subject><subject>Animals</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Antibody response</subject><subject>antigens</subject><subject>Antigens, Bacterial</subject><subject>Applied microbiology</subject><subject>Bacteriology</subject><subject>Bioinformatics</subject><subject>Biological and medical sciences</subject><subject>Cell Wall - immunology</subject><subject>Chromatography</subject><subject>cross reaction</subject><subject>Cross Reactions</subject><subject>Delayed type hypersensitivity</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunization</subject><subject>immunoglobulin G</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin G - immunology</subject><subject>Laboratory animals</subject><subject>Lipids</subject><subject>M. tuberculosis</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mortality</subject><subject>Mycobacterium bovis - immunology</subject><subject>Mycobacterium smegmatis</subject><subject>Mycobacterium smegmatis - immunology</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - immunology</subject><subject>Proteins</subject><subject>Proteolipids - immunology</subject><subject>Proteoliposomes</subject><subject>structural proteins</subject><subject>Transmission electron microscopy</subject><subject>Tuberculosis</subject><subject>Tuberculosis - immunology</subject><subject>Tuberculosis - prevention & control</subject><subject>Tuberculosis Vaccines</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk-P0zAQxSMEYrsLHwGIhBCnlJnYceILCK34Jy0CaVmJm-U4k8olsYudVOppvzouLazUy17sg3_zPPPeZNkzhCUCijfr5VYbYx0tS0BcglhCXT_IFtjUrCgrbB5mCygFLzjCz7PsPMY1AFQM5ePsrMSaCYl8kd1-D34iP9iNj36kmPfBj_nXnfGtNhMFO495HGk16snG3LpuNpTbcZwd5Sb4GItACbRbO-1yvdLWxemkfJpbCmYefEwK2k12RW4vlY_W0JPsUa-HSE-P90V28_HDj8vPxdW3T18u318VpmJsKlrWNG0Hkkojq7Lt-rY1zEghGIq2QWw1M3WFvcH0qjueDkLR9ByISwmSXWSvD7qb4H_PFCc12mhoGLQjP0fVSMYQZTLvXrJhTZWMFIl8eUKu_RxcGkMhlw3IWgJLVHWg_toVqFebYEcddgpB7aNUa3WMUu2jVCBUijLVPT-qz-1I3f-qf9kl4NUR0NHooQ_aGRvvOM5rkeZJ3IsD12uv9Cok5uY6_VQBIC-BN4l4dyAoJbC1FFQ0lpyhzgYyk-q8vbfZtycKZrDOprZ-0Y7inS8qlgrU9X4z94uJCCArBPYHbfLgAg</recordid><startdate>20110826</startdate><enddate>20110826</enddate><creator>Rodriguez, Lissete</creator><creator>Tirado, Yanelys</creator><creator>Reyes, Fatima</creator><creator>Puig, Alina</creator><creator>Kadir, Ramlah</creator><creator>Borrero, Reinier</creator><creator>Fernandez, Sonsire</creator><creator>Reyes, Giselle</creator><creator>Alvarez, Nadine</creator><creator>Garcia, Maria Angeles</creator><creator>Sarmiento, Maria Elena</creator><creator>Norazmi, Mohd Nor</creator><creator>Perez Quinoy, Jose Luis</creator><creator>Acosta, Armando</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110826</creationdate><title>Proteoliposomes from Mycobacterium smegmatis induce immune cross-reactivity against Mycobacterium tuberculosis antigens in mice</title><author>Rodriguez, Lissete ; 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Animals immunized with PL adjuvanted with alum (PL–AL) or Freund's Incomplete Adjuvant (PL–IFA) showed significant IgG responses against the PL as well as total Ms lipids. Both groups of animals also showed significant IgG responses against BCG, but only animals immunized with PL–AL produced significant IgG responses against soluble cell wall proteins (SCWP) or whole cell lysate (WCL) of Mtb. Significant DTH responses against WCL were observed in both groups of animals after 24h, but only PL–AL-immunized mice showed significant DTH responses after 48h and 72h. PL–Ms are capable of eliciting cross-reactive humoral and cellular responses against Mtb antigens and thus may be a potential vaccine strategy against tuberculosis.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21736914</pmid><doi>10.1016/j.vaccine.2011.06.077</doi><tpages>6</tpages></addata></record> |
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| subjects | Adjuvants, Immunologic Advantages Allergy and Immunology alum Alum Compounds - pharmacology Animals Antibodies, Bacterial - immunology Antibody response antigens Antigens, Bacterial Applied microbiology Bacteriology Bioinformatics Biological and medical sciences Cell Wall - immunology Chromatography cross reaction Cross Reactions Delayed type hypersensitivity Female Fundamental and applied biological sciences. Psychology Immunization immunoglobulin G Immunoglobulin G - biosynthesis Immunoglobulin G - immunology Laboratory animals Lipids M. tuberculosis Mice Mice, Inbred BALB C Microbiology Miscellaneous Mortality Mycobacterium bovis - immunology Mycobacterium smegmatis Mycobacterium smegmatis - immunology Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Proteins Proteolipids - immunology Proteoliposomes structural proteins Transmission electron microscopy Tuberculosis Tuberculosis - immunology Tuberculosis - prevention & control Tuberculosis Vaccines Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Proteoliposomes from Mycobacterium smegmatis induce immune cross-reactivity against Mycobacterium tuberculosis antigens in mice |
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