Trichostatin A inhibits collagen synthesis and induces apoptosis in keloid fibroblasts

Keloid, a fibro-proliferative benign tumor of skin, is characterized by an enriched milieu of growth factors and an abundant accumulation of extracellular matrix (ECM). Transforming growth factor (TGF)-β1 is well known as the crucial fibrogenic cytokine promoting ECM production and tissue fibrosis i...

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Veröffentlicht in:	Archives of Dermatological Research 2011-10, Vol.303 (8), p.573-580
Hauptverfasser:	Diao, Jian-Sheng, Xia, Wen-Sen, Yi, Cheng-Gang, Wang, Ying-Mei, Li, Bing, Xia, Wei, Liu, Bei, Guo, Shu-Zhong, Sun, Xu-De
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Apoptosis - drug effects Biological and medical sciences Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Child Collagen - metabolism Dermatology Female Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic Acids - pharmacology Keloid - metabolism Keloid - pathology Male Medical sciences Medicine Medicine & Public Health Original Paper Skin involvement in other diseases. Miscellaneous. General aspects Transforming Growth Factor beta1 - pharmacology Young Adult
Online-Zugang:	Volltext
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