Association of polymorphisms in glutamate-cysteine ligase catalytic subunit and microsomal triglyceride transfer protein genes with nonalcoholic fatty liver disease
Genetic and environmental factors are important for the development of nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to examine the single nucleotide polymorphism (SNP) -129C/T (rs17883901) in glutamate-cysteine ligase catalytic subunit (GCLC) and SNPs I128T (rs3816873)...
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| Veröffentlicht in: | DNA and cell biology 2011-08, Vol.30 (8), p.569-575 |
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| creator | Hashemi, Mohammad Hoseini, Hosnieh Yaghmaei, Parichehreh Moazeni-Roodi, Abdolkarim Bahari, Ali Hashemzehi, Norallah Shafieipour, Sara |
| description | Genetic and environmental factors are important for the development of nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to examine the single nucleotide polymorphism (SNP) -129C/T (rs17883901) in glutamate-cysteine ligase catalytic subunit (GCLC) and SNPs I128T (rs3816873) and Q95H (rs61733139) in microsomal triglyceride transfer protein (MTTP) in NAFLD. Eighty-three patients with a diagnosis of NAFLD and 93 healthy subjects were included in the study. Tetra amplification refractory mutation system-polymerase chain reaction was designed to detect the SNPs. There were no significant differences in the polymorphism of -129C/T (rs17883901) of the GCLC gene among NAFLD and control groups (p > 0.05). A significant difference was observed between NAFLD and control group regarding the SNP I128T (rs3816873) in the coding region of the MTTP gene (p |
| doi_str_mv | 10.1089/dna.2010.1162 |
| format | Article |
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The aim of the present study was to examine the single nucleotide polymorphism (SNP) -129C/T (rs17883901) in glutamate-cysteine ligase catalytic subunit (GCLC) and SNPs I128T (rs3816873) and Q95H (rs61733139) in microsomal triglyceride transfer protein (MTTP) in NAFLD. Eighty-three patients with a diagnosis of NAFLD and 93 healthy subjects were included in the study. Tetra amplification refractory mutation system-polymerase chain reaction was designed to detect the SNPs. There were no significant differences in the polymorphism of -129C/T (rs17883901) of the GCLC gene among NAFLD and control groups (p > 0.05). A significant difference was observed between NAFLD and control group regarding the SNP I128T (rs3816873) in the coding region of the MTTP gene (p < 0.05). The CT genotype increased susceptibility to NAFLD (OR: 2.467; 95% CI: 1.253-4.854; p = 0.008). No significant difference was found among the groups regarding the SNP in the coding region of MTTP gene Q95H (rs61733139). In conclusion, MTTP rs3816873 polymorphism might be a candidate to determine susceptibility to NAFLD. Larger studies are necessary to confirm these findings in various populations.</description><identifier>ISSN: 1044-5498</identifier><identifier>EISSN: 1557-7430</identifier><identifier>DOI: 10.1089/dna.2010.1162</identifier><identifier>PMID: 21438662</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carrier Proteins - genetics ; Case-Control Studies ; Catalytic Domain - genetics ; Fatty Liver - enzymology ; Fatty Liver - genetics ; Female ; Genotype ; Glutamate-Cysteine Ligase - chemistry ; Glutamate-Cysteine Ligase - genetics ; Humans ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease ; Polymorphism, Single Nucleotide ; Young Adult</subject><ispartof>DNA and cell biology, 2011-08, Vol.30 (8), p.569-575</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-8d73a009c66943f92f9ab96d9175538c53578b3f7dc1b1b848f180d55e81f3333</citedby><cites>FETCH-LOGICAL-c324t-8d73a009c66943f92f9ab96d9175538c53578b3f7dc1b1b848f180d55e81f3333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21438662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashemi, Mohammad</creatorcontrib><creatorcontrib>Hoseini, Hosnieh</creatorcontrib><creatorcontrib>Yaghmaei, Parichehreh</creatorcontrib><creatorcontrib>Moazeni-Roodi, Abdolkarim</creatorcontrib><creatorcontrib>Bahari, Ali</creatorcontrib><creatorcontrib>Hashemzehi, Norallah</creatorcontrib><creatorcontrib>Shafieipour, Sara</creatorcontrib><title>Association of polymorphisms in glutamate-cysteine ligase catalytic subunit and microsomal triglyceride transfer protein genes with nonalcoholic fatty liver disease</title><title>DNA and cell biology</title><addtitle>DNA Cell Biol</addtitle><description>Genetic and environmental factors are important for the development of nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to examine the single nucleotide polymorphism (SNP) -129C/T (rs17883901) in glutamate-cysteine ligase catalytic subunit (GCLC) and SNPs I128T (rs3816873) and Q95H (rs61733139) in microsomal triglyceride transfer protein (MTTP) in NAFLD. Eighty-three patients with a diagnosis of NAFLD and 93 healthy subjects were included in the study. Tetra amplification refractory mutation system-polymerase chain reaction was designed to detect the SNPs. There were no significant differences in the polymorphism of -129C/T (rs17883901) of the GCLC gene among NAFLD and control groups (p > 0.05). A significant difference was observed between NAFLD and control group regarding the SNP I128T (rs3816873) in the coding region of the MTTP gene (p < 0.05). The CT genotype increased susceptibility to NAFLD (OR: 2.467; 95% CI: 1.253-4.854; p = 0.008). No significant difference was found among the groups regarding the SNP in the coding region of MTTP gene Q95H (rs61733139). In conclusion, MTTP rs3816873 polymorphism might be a candidate to determine susceptibility to NAFLD. Larger studies are necessary to confirm these findings in various populations.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carrier Proteins - genetics</subject><subject>Case-Control Studies</subject><subject>Catalytic Domain - genetics</subject><subject>Fatty Liver - enzymology</subject><subject>Fatty Liver - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>Glutamate-Cysteine Ligase - chemistry</subject><subject>Glutamate-Cysteine Ligase - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-alcoholic Fatty Liver Disease</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Young Adult</subject><issn>1044-5498</issn><issn>1557-7430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtvFTEQRi0EIiFJSYvcUW3wc22XURQeUiQaUq-8ftxr5LUvtpdo_09-KF4l0OJmPNLRN6M5ALzH6BojqT7ZpK8J2js8klfgHHMuBsEoet3_iLGBMyXPwLtafyKEOMHoLTgjmFE5juQcPN3Umk3QLeQEs4enHLcll9Mx1KXCkOAhrk0vurnBbLW5kByM4aCrg0Y3HbcWDKzrvKbQoE4WLsGUXPOiI2wlHOJmXAnW9Uan6l2Bp5L3GHhwyVX4GNoRppx0NPmYYw_zurWtz_jdWRuq66MuwRuvY3VXL_UCPHy--3H7dbj__uXb7c39YChhbZBWUI2QMuOoGPWKeKVnNVqFBedUGk65kDP1who841ky6bFElnMnsaf9XYCPz7l9x1-rq21aQjUuRp1cXuskFSWCEMT-T0qEqUCCd3J4Jvez1OL8dCph0WWbMJp2g1M3OO0Gp91g5z-8JK_z4uw_-q8y-gfWDptM</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Hashemi, Mohammad</creator><creator>Hoseini, Hosnieh</creator><creator>Yaghmaei, Parichehreh</creator><creator>Moazeni-Roodi, Abdolkarim</creator><creator>Bahari, Ali</creator><creator>Hashemzehi, Norallah</creator><creator>Shafieipour, Sara</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T7</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20110801</creationdate><title>Association of polymorphisms in glutamate-cysteine ligase catalytic subunit and microsomal triglyceride transfer protein genes with nonalcoholic fatty liver disease</title><author>Hashemi, Mohammad ; Hoseini, Hosnieh ; Yaghmaei, Parichehreh ; Moazeni-Roodi, Abdolkarim ; Bahari, Ali ; Hashemzehi, Norallah ; Shafieipour, Sara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-8d73a009c66943f92f9ab96d9175538c53578b3f7dc1b1b848f180d55e81f3333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carrier Proteins - genetics</topic><topic>Case-Control Studies</topic><topic>Catalytic Domain - genetics</topic><topic>Fatty Liver - enzymology</topic><topic>Fatty Liver - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>Glutamate-Cysteine Ligase - chemistry</topic><topic>Glutamate-Cysteine Ligase - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-alcoholic Fatty Liver Disease</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashemi, Mohammad</creatorcontrib><creatorcontrib>Hoseini, Hosnieh</creatorcontrib><creatorcontrib>Yaghmaei, Parichehreh</creatorcontrib><creatorcontrib>Moazeni-Roodi, Abdolkarim</creatorcontrib><creatorcontrib>Bahari, Ali</creatorcontrib><creatorcontrib>Hashemzehi, Norallah</creatorcontrib><creatorcontrib>Shafieipour, Sara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>DNA and cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashemi, Mohammad</au><au>Hoseini, Hosnieh</au><au>Yaghmaei, Parichehreh</au><au>Moazeni-Roodi, Abdolkarim</au><au>Bahari, Ali</au><au>Hashemzehi, Norallah</au><au>Shafieipour, Sara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of polymorphisms in glutamate-cysteine ligase catalytic subunit and microsomal triglyceride transfer protein genes with nonalcoholic fatty liver disease</atitle><jtitle>DNA and cell biology</jtitle><addtitle>DNA Cell Biol</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>30</volume><issue>8</issue><spage>569</spage><epage>575</epage><pages>569-575</pages><issn>1044-5498</issn><eissn>1557-7430</eissn><abstract>Genetic and environmental factors are important for the development of nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to examine the single nucleotide polymorphism (SNP) -129C/T (rs17883901) in glutamate-cysteine ligase catalytic subunit (GCLC) and SNPs I128T (rs3816873) and Q95H (rs61733139) in microsomal triglyceride transfer protein (MTTP) in NAFLD. Eighty-three patients with a diagnosis of NAFLD and 93 healthy subjects were included in the study. Tetra amplification refractory mutation system-polymerase chain reaction was designed to detect the SNPs. There were no significant differences in the polymorphism of -129C/T (rs17883901) of the GCLC gene among NAFLD and control groups (p > 0.05). A significant difference was observed between NAFLD and control group regarding the SNP I128T (rs3816873) in the coding region of the MTTP gene (p < 0.05). The CT genotype increased susceptibility to NAFLD (OR: 2.467; 95% CI: 1.253-4.854; p = 0.008). No significant difference was found among the groups regarding the SNP in the coding region of MTTP gene Q95H (rs61733139). In conclusion, MTTP rs3816873 polymorphism might be a candidate to determine susceptibility to NAFLD. Larger studies are necessary to confirm these findings in various populations.</abstract><cop>United States</cop><pmid>21438662</pmid><doi>10.1089/dna.2010.1162</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Carrier Proteins - genetics Case-Control Studies Catalytic Domain - genetics Fatty Liver - enzymology Fatty Liver - genetics Female Genotype Glutamate-Cysteine Ligase - chemistry Glutamate-Cysteine Ligase - genetics Humans Male Middle Aged Non-alcoholic Fatty Liver Disease Polymorphism, Single Nucleotide Young Adult |
| title | Association of polymorphisms in glutamate-cysteine ligase catalytic subunit and microsomal triglyceride transfer protein genes with nonalcoholic fatty liver disease |
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