Dyslipidemia in subclinical hypothyroidism in an Indian population
In view of inconsistent reports on the prevalence of dyslipidemia in subclinical hypothyroidism (SCH), we studied lipid abnormalities in Indian subjects with SCH. A cross sectional study of 5343 subjects divided in two groups, Group-1 (age ≤ 18 years) and Group-2 (age > 18 years) was undertaken....
Gespeichert in:
| Veröffentlicht in: | Clinical biochemistry 2011-10, Vol.44 (14), p.1214-1217 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1217 |
|---|---|
| container_issue | 14 |
| container_start_page | 1214 |
| container_title | Clinical biochemistry |
| container_volume | 44 |
| creator | Marwaha, Raman K. Tandon, Nikhil Garg, M.K. Kanwar, Ratnesh Sastry, A. Narang, A. Arora, S. Bhadra, Kuntal |
| description | In view of inconsistent reports on the prevalence of dyslipidemia in subclinical hypothyroidism (SCH), we studied lipid abnormalities in Indian subjects with SCH.
A cross sectional study of 5343 subjects divided in two groups, Group-1 (age
≤
18
years) and Group-2 (age
>
18
years) was undertaken. They were further subdivided on the basis of their thyroid functional status: Normal (Control); SCH with TSH
≤
10.0
mIU/L (SCH-1); and SCH with TSH
>
10
mIU/L (SCH-2).
Prevalence of SCH was 14.7%. The only lipid abnormality in children and adolescents was low HDL in subjects with TSH
>
10
mIU/L compared with controls. Serum total cholesterol (TC), and LDL cholesterol (LDL) were significantly higher in adults with TSH
>
10
mIU/L compared to controls. There were no significant changes in lipid parameters in subjects with SCH having TSH
≤
10.0
mIU/L, compared to controls. Serum TSH was positively and FT3 and FT4 were negatively correlated with TC and LDL.
Atherogenic lipid abnormalities were observed in adult subjects with SCH-2 (TSH
>
10.0
mIU/L), and not in subjects with SCH-1 who had TSH
≤
10.0
mIU/L in Indian population. |
| doi_str_mv | 10.1016/j.clinbiochem.2011.07.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_893271978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0009912011014147</els_id><sourcerecordid>893271978</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-d962c0de915390ba01780095959fefe0484c762f2f142e87536ed7ad875e4dff3</originalsourceid><addsrcrecordid>eNqNkE2P0zAQhi3Eare77F9A5YA4JTu20zg-QoFlpZW4wNly7bE6VRIHO0Hqv8dVy8cR-TC2_MzMq4exNxxqDrx9ONSup3FH0e1xqAVwXoOqAeQLtuKdkpXQUr5kKwDQleYCbthtzofyFE3XXrMbwVUnOlAr9uHjMfc0kceB7JrGdV52p-HkbL_eH6c4748pkqc8nH7tuH4aPZUyxWnp7UxxfMWugu0z3l_qHfv--dO37Zfq-evj0_b9c-UaaOfK61Y48Kj5RmrYWSgZSr5NOQEDQtM1TrUiiMAbgZ3ayBa9sr7csPEhyDv27jx3SvHHgnk2A2WHfW9HjEs2nZZCca26Quoz6VLMOWEwU6LBpqPhYE4GzcH8Y9CcDBpQphgsva8vW5bdgP5P529lBXh7AWwukkKyo6P8l2takBspCrc9c1ic_CRMJjvC0aGnhG42PtJ_xPkF5zeU1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>893271978</pqid></control><display><type>article</type><title>Dyslipidemia in subclinical hypothyroidism in an Indian population</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Marwaha, Raman K. ; Tandon, Nikhil ; Garg, M.K. ; Kanwar, Ratnesh ; Sastry, A. ; Narang, A. ; Arora, S. ; Bhadra, Kuntal</creator><creatorcontrib>Marwaha, Raman K. ; Tandon, Nikhil ; Garg, M.K. ; Kanwar, Ratnesh ; Sastry, A. ; Narang, A. ; Arora, S. ; Bhadra, Kuntal</creatorcontrib><description>In view of inconsistent reports on the prevalence of dyslipidemia in subclinical hypothyroidism (SCH), we studied lipid abnormalities in Indian subjects with SCH.
A cross sectional study of 5343 subjects divided in two groups, Group-1 (age
≤
18
years) and Group-2 (age
>
18
years) was undertaken. They were further subdivided on the basis of their thyroid functional status: Normal (Control); SCH with TSH
≤
10.0
mIU/L (SCH-1); and SCH with TSH
>
10
mIU/L (SCH-2).
Prevalence of SCH was 14.7%. The only lipid abnormality in children and adolescents was low HDL in subjects with TSH
>
10
mIU/L compared with controls. Serum total cholesterol (TC), and LDL cholesterol (LDL) were significantly higher in adults with TSH
>
10
mIU/L compared to controls. There were no significant changes in lipid parameters in subjects with SCH having TSH
≤
10.0
mIU/L, compared to controls. Serum TSH was positively and FT3 and FT4 were negatively correlated with TC and LDL.
Atherogenic lipid abnormalities were observed in adult subjects with SCH-2 (TSH
>
10.0
mIU/L), and not in subjects with SCH-1 who had TSH
≤
10.0
mIU/L in Indian population.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2011.07.003</identifier><identifier>PMID: 21782807</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Anti-TPO antibodies ; Biological and medical sciences ; Child ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cross-Sectional Studies ; Dyslipidemias - epidemiology ; Dyslipidemias - metabolism ; Endocrinopathies ; Humans ; Hypothyroidism - complications ; Hypothyroidism - metabolism ; India ; Investigative techniques, diagnostic techniques (general aspects) ; Lipid profile ; Lipids - blood ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Subclinical hypothyroidism ; Thyroid Gland - physiopathology ; Thyroid. Thyroid axis (diseases) ; Thyrotropin - blood</subject><ispartof>Clinical biochemistry, 2011-10, Vol.44 (14), p.1214-1217</ispartof><rights>2011 The Canadian Society of Clinical Chemists</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-d962c0de915390ba01780095959fefe0484c762f2f142e87536ed7ad875e4dff3</citedby><cites>FETCH-LOGICAL-c406t-d962c0de915390ba01780095959fefe0484c762f2f142e87536ed7ad875e4dff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009912011014147$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24603532$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21782807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marwaha, Raman K.</creatorcontrib><creatorcontrib>Tandon, Nikhil</creatorcontrib><creatorcontrib>Garg, M.K.</creatorcontrib><creatorcontrib>Kanwar, Ratnesh</creatorcontrib><creatorcontrib>Sastry, A.</creatorcontrib><creatorcontrib>Narang, A.</creatorcontrib><creatorcontrib>Arora, S.</creatorcontrib><creatorcontrib>Bhadra, Kuntal</creatorcontrib><title>Dyslipidemia in subclinical hypothyroidism in an Indian population</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>In view of inconsistent reports on the prevalence of dyslipidemia in subclinical hypothyroidism (SCH), we studied lipid abnormalities in Indian subjects with SCH.
A cross sectional study of 5343 subjects divided in two groups, Group-1 (age
≤
18
years) and Group-2 (age
>
18
years) was undertaken. They were further subdivided on the basis of their thyroid functional status: Normal (Control); SCH with TSH
≤
10.0
mIU/L (SCH-1); and SCH with TSH
>
10
mIU/L (SCH-2).
Prevalence of SCH was 14.7%. The only lipid abnormality in children and adolescents was low HDL in subjects with TSH
>
10
mIU/L compared with controls. Serum total cholesterol (TC), and LDL cholesterol (LDL) were significantly higher in adults with TSH
>
10
mIU/L compared to controls. There were no significant changes in lipid parameters in subjects with SCH having TSH
≤
10.0
mIU/L, compared to controls. Serum TSH was positively and FT3 and FT4 were negatively correlated with TC and LDL.
Atherogenic lipid abnormalities were observed in adult subjects with SCH-2 (TSH
>
10.0
mIU/L), and not in subjects with SCH-1 who had TSH
≤
10.0
mIU/L in Indian population.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-TPO antibodies</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>Dyslipidemias - epidemiology</subject><subject>Dyslipidemias - metabolism</subject><subject>Endocrinopathies</subject><subject>Humans</subject><subject>Hypothyroidism - complications</subject><subject>Hypothyroidism - metabolism</subject><subject>India</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lipid profile</subject><subject>Lipids - blood</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Subclinical hypothyroidism</subject><subject>Thyroid Gland - physiopathology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Thyrotropin - blood</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE2P0zAQhi3Eare77F9A5YA4JTu20zg-QoFlpZW4wNly7bE6VRIHO0Hqv8dVy8cR-TC2_MzMq4exNxxqDrx9ONSup3FH0e1xqAVwXoOqAeQLtuKdkpXQUr5kKwDQleYCbthtzofyFE3XXrMbwVUnOlAr9uHjMfc0kceB7JrGdV52p-HkbL_eH6c4748pkqc8nH7tuH4aPZUyxWnp7UxxfMWugu0z3l_qHfv--dO37Zfq-evj0_b9c-UaaOfK61Y48Kj5RmrYWSgZSr5NOQEDQtM1TrUiiMAbgZ3ayBa9sr7csPEhyDv27jx3SvHHgnk2A2WHfW9HjEs2nZZCca26Quoz6VLMOWEwU6LBpqPhYE4GzcH8Y9CcDBpQphgsva8vW5bdgP5P529lBXh7AWwukkKyo6P8l2takBspCrc9c1ic_CRMJjvC0aGnhG42PtJ_xPkF5zeU1g</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Marwaha, Raman K.</creator><creator>Tandon, Nikhil</creator><creator>Garg, M.K.</creator><creator>Kanwar, Ratnesh</creator><creator>Sastry, A.</creator><creator>Narang, A.</creator><creator>Arora, S.</creator><creator>Bhadra, Kuntal</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Dyslipidemia in subclinical hypothyroidism in an Indian population</title><author>Marwaha, Raman K. ; Tandon, Nikhil ; Garg, M.K. ; Kanwar, Ratnesh ; Sastry, A. ; Narang, A. ; Arora, S. ; Bhadra, Kuntal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-d962c0de915390ba01780095959fefe0484c762f2f142e87536ed7ad875e4dff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-TPO antibodies</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cross-Sectional Studies</topic><topic>Dyslipidemias - epidemiology</topic><topic>Dyslipidemias - metabolism</topic><topic>Endocrinopathies</topic><topic>Humans</topic><topic>Hypothyroidism - complications</topic><topic>Hypothyroidism - metabolism</topic><topic>India</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lipid profile</topic><topic>Lipids - blood</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Subclinical hypothyroidism</topic><topic>Thyroid Gland - physiopathology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Thyrotropin - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marwaha, Raman K.</creatorcontrib><creatorcontrib>Tandon, Nikhil</creatorcontrib><creatorcontrib>Garg, M.K.</creatorcontrib><creatorcontrib>Kanwar, Ratnesh</creatorcontrib><creatorcontrib>Sastry, A.</creatorcontrib><creatorcontrib>Narang, A.</creatorcontrib><creatorcontrib>Arora, S.</creatorcontrib><creatorcontrib>Bhadra, Kuntal</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marwaha, Raman K.</au><au>Tandon, Nikhil</au><au>Garg, M.K.</au><au>Kanwar, Ratnesh</au><au>Sastry, A.</au><au>Narang, A.</au><au>Arora, S.</au><au>Bhadra, Kuntal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dyslipidemia in subclinical hypothyroidism in an Indian population</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>44</volume><issue>14</issue><spage>1214</spage><epage>1217</epage><pages>1214-1217</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>In view of inconsistent reports on the prevalence of dyslipidemia in subclinical hypothyroidism (SCH), we studied lipid abnormalities in Indian subjects with SCH.
A cross sectional study of 5343 subjects divided in two groups, Group-1 (age
≤
18
years) and Group-2 (age
>
18
years) was undertaken. They were further subdivided on the basis of their thyroid functional status: Normal (Control); SCH with TSH
≤
10.0
mIU/L (SCH-1); and SCH with TSH
>
10
mIU/L (SCH-2).
Prevalence of SCH was 14.7%. The only lipid abnormality in children and adolescents was low HDL in subjects with TSH
>
10
mIU/L compared with controls. Serum total cholesterol (TC), and LDL cholesterol (LDL) were significantly higher in adults with TSH
>
10
mIU/L compared to controls. There were no significant changes in lipid parameters in subjects with SCH having TSH
≤
10.0
mIU/L, compared to controls. Serum TSH was positively and FT3 and FT4 were negatively correlated with TC and LDL.
Atherogenic lipid abnormalities were observed in adult subjects with SCH-2 (TSH
>
10.0
mIU/L), and not in subjects with SCH-1 who had TSH
≤
10.0
mIU/L in Indian population.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>21782807</pmid><doi>10.1016/j.clinbiochem.2011.07.003</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9120 |
| ispartof | Clinical biochemistry, 2011-10, Vol.44 (14), p.1214-1217 |
| issn | 0009-9120 1873-2933 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_893271978 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Anti-TPO antibodies Biological and medical sciences Child Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Cross-Sectional Studies Dyslipidemias - epidemiology Dyslipidemias - metabolism Endocrinopathies Humans Hypothyroidism - complications Hypothyroidism - metabolism India Investigative techniques, diagnostic techniques (general aspects) Lipid profile Lipids - blood Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Subclinical hypothyroidism Thyroid Gland - physiopathology Thyroid. Thyroid axis (diseases) Thyrotropin - blood |
| title | Dyslipidemia in subclinical hypothyroidism in an Indian population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T03%3A02%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dyslipidemia%20in%20subclinical%20hypothyroidism%20in%20an%20Indian%20population&rft.jtitle=Clinical%20biochemistry&rft.au=Marwaha,%20Raman%20K.&rft.date=2011-10-01&rft.volume=44&rft.issue=14&rft.spage=1214&rft.epage=1217&rft.pages=1214-1217&rft.issn=0009-9120&rft.eissn=1873-2933&rft_id=info:doi/10.1016/j.clinbiochem.2011.07.003&rft_dat=%3Cproquest_cross%3E893271978%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=893271978&rft_id=info:pmid/21782807&rft_els_id=S0009912011014147&rfr_iscdi=true |