Lesions of nucleus accumbens affect morphine-induced release of ascorbic acid and GABA but not of glutamate in rats

ABSTRACT Our previous studies have shown that local perfusion of morphine causes an increase of extracellular ascorbic acid (AA) levels in nucleus accumbens (NAc) of freely moving rats. Lines of evidence showed that glutamatergic and GABAergic were associated with morphine‐induced effects on the neu...

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Veröffentlicht in:	Addiction biology 2011-10, Vol.16 (4), p.540-550
Hauptverfasser:	Sun, Ji Y., Yang, Jing Y., Wang, Fang, Wang, Jian Y., Song, Wu, Su, Guang Y., Dong, Ying X., Wu, Chun F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascorbic acid Ascorbic Acid - metabolism Chromatography, High Pressure Liquid - methods Dose-Response Relationship, Drug Excitatory Amino Acid Agonists Extracellular Fluid - metabolism gamma-Aminobutyric Acid - metabolism glutamate Glutamic Acid - metabolism Kainic Acid microdialysis morphine Morphine - pharmacology Naloxone - pharmacology Narcotic Antagonists - pharmacology Narcotics - pharmacology Nerve Net - drug effects Nerve Net - pathology nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - pathology Perfusion Rats Rats, Sprague-Dawley Receptors, GABA - drug effects Receptors, Opioid, mu - drug effects γ-aminobutyric acid
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