The association of systemic disorders with Vogt–Koyanagi–Harada and sympathetic ophthalmia
Background The aim of this work is to determine the systemic diseases and malignancy associated with Vogt–Koyanagi–Harada (VKH) disease compared to sympathetic ophthalmia (SO). Methods We conducted a retrospective comparative observational clinical study where the medical records of patients with th...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2011-08, Vol.249 (8), p.1229-1233 |
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| creator | Al-Halafi, Ali Dhibi, Hassan Al Hamade, Issam H. Bou Chacra, Charbel T. Tabbara, Khalid F. |
| description | Background
The aim of this work is to determine the systemic diseases and malignancy associated with Vogt–Koyanagi–Harada (VKH) disease compared to sympathetic ophthalmia (SO).
Methods
We conducted a retrospective comparative observational clinical study where the medical records of patients with the diagnosis of VKH and SO from 1999–2009 were reviewed. The study was carried out at the King Khaled Eye Specialist Hospital and The Eye Center in Riyadh, Saudi Arabia. Investigators recorded the age, gender, history of trauma, associated systemic disorders, and ocular and systemic manifestations. Patients were examined by an ophthalmologist as well as an internist.
Results
A total of 316 patients were included: 256 patients had VKH and 60 patients had SO. The age range in the VKH group was 3–62 years with a mean age of 29 ± 13 years. The age range in the SO group was 4–90 years with a mean age of 36 ± 20 years. The mean follow-up period of patients with VKH was 58 ± 50 months and patients with SO was 61 ± 54 months. Out of 256 patients with VKH, there were 41 (16%) with systemic disorders. Comparatively, out of 60 patients with SO, no associated systemic autoimmune disorders or tumors were encountered. The difference between the VKH and SO groups was statistically significant (
p
= 0.003).
Conclusions
VKH and SO are autoimmune disorders targeting melanin-bearing cells. Both diseases are characterized by immunologic dysregulation. We found a statistically significant association of systemic disorders and malignancy with VKH compared to SO. This finding may suggest that the two disorders may have different etiology with similar ocular and systemic manifestations. |
| doi_str_mv | 10.1007/s00417-011-1727-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_893265379</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2418326051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-da7b19d7e711f4e83f9638c474e7ce1b9aa414f899c19fd652fd44bf36dc78c53</originalsourceid><addsrcrecordid>eNp1kM1OGzEURq2qqATaB-gGjbphNeA79sSeZYWgoCKxgSqrWjf-yRhlxqntCGXXd-gb8iQYJQUJCXlxLd3zfbYOIV-BngCl4jRRykHUFKAG0YiafyAT4KytBW1mH8mEigZqyZrZPjlI6Z4WnLXwiew3IMqRdEJ-3_a2wpSC9ph9GKvgqrRJ2Q5eV8anEI2NqXrwua9-hUV-_PvvZ9jgiAtfrpcY0WCFoymhYYW5t7nkwqrPPS4Hj5_JnsNlsl9285DcXZzfnl3W1zc_rs6-X9eaCZprg2IOnRFWADhuJXPdlEnNBbdCW5h3iBy4k12noXNm2jbOcD53bGq0kLplh-R427uK4c_apqwGn7RdLnG0YZ2U7FgzbZnoCvntDXkf1nEsn1NSAmtZQQsEW0jHkFK0Tq2iHzBuFFD1rF5t1auiXj2rV7xkjnbF6_lgzUviv-sCNFsgldW4sPH15fdbnwAij5Gc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>881353893</pqid></control><display><type>article</type><title>The association of systemic disorders with Vogt–Koyanagi–Harada and sympathetic ophthalmia</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Al-Halafi, Ali ; Dhibi, Hassan Al ; Hamade, Issam H. ; Bou Chacra, Charbel T. ; Tabbara, Khalid F.</creator><creatorcontrib>Al-Halafi, Ali ; Dhibi, Hassan Al ; Hamade, Issam H. ; Bou Chacra, Charbel T. ; Tabbara, Khalid F.</creatorcontrib><description>Background
The aim of this work is to determine the systemic diseases and malignancy associated with Vogt–Koyanagi–Harada (VKH) disease compared to sympathetic ophthalmia (SO).
Methods
We conducted a retrospective comparative observational clinical study where the medical records of patients with the diagnosis of VKH and SO from 1999–2009 were reviewed. The study was carried out at the King Khaled Eye Specialist Hospital and The Eye Center in Riyadh, Saudi Arabia. Investigators recorded the age, gender, history of trauma, associated systemic disorders, and ocular and systemic manifestations. Patients were examined by an ophthalmologist as well as an internist.
Results
A total of 316 patients were included: 256 patients had VKH and 60 patients had SO. The age range in the VKH group was 3–62 years with a mean age of 29 ± 13 years. The age range in the SO group was 4–90 years with a mean age of 36 ± 20 years. The mean follow-up period of patients with VKH was 58 ± 50 months and patients with SO was 61 ± 54 months. Out of 256 patients with VKH, there were 41 (16%) with systemic disorders. Comparatively, out of 60 patients with SO, no associated systemic autoimmune disorders or tumors were encountered. The difference between the VKH and SO groups was statistically significant (
p
= 0.003).
Conclusions
VKH and SO are autoimmune disorders targeting melanin-bearing cells. Both diseases are characterized by immunologic dysregulation. We found a statistically significant association of systemic disorders and malignancy with VKH compared to SO. This finding may suggest that the two disorders may have different etiology with similar ocular and systemic manifestations.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-011-1727-4</identifier><identifier>PMID: 21717180</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Autoimmune Diseases - complications ; Autoimmune Diseases - diagnosis ; Child ; Child, Preschool ; Eye Diseases - complications ; Eye Diseases - diagnosis ; Female ; Humans ; Inflammatory Disorders ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasms - complications ; Neoplasms - diagnosis ; Ophthalmia, Sympathetic - complications ; Ophthalmia, Sympathetic - diagnosis ; Ophthalmology ; Retrospective Studies ; Uveomeningoencephalitic Syndrome - complications ; Uveomeningoencephalitic Syndrome - diagnosis</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2011-08, Vol.249 (8), p.1229-1233</ispartof><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-da7b19d7e711f4e83f9638c474e7ce1b9aa414f899c19fd652fd44bf36dc78c53</citedby><cites>FETCH-LOGICAL-c370t-da7b19d7e711f4e83f9638c474e7ce1b9aa414f899c19fd652fd44bf36dc78c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-011-1727-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-011-1727-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21717180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Halafi, Ali</creatorcontrib><creatorcontrib>Dhibi, Hassan Al</creatorcontrib><creatorcontrib>Hamade, Issam H.</creatorcontrib><creatorcontrib>Bou Chacra, Charbel T.</creatorcontrib><creatorcontrib>Tabbara, Khalid F.</creatorcontrib><title>The association of systemic disorders with Vogt–Koyanagi–Harada and sympathetic ophthalmia</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Background
The aim of this work is to determine the systemic diseases and malignancy associated with Vogt–Koyanagi–Harada (VKH) disease compared to sympathetic ophthalmia (SO).
Methods
We conducted a retrospective comparative observational clinical study where the medical records of patients with the diagnosis of VKH and SO from 1999–2009 were reviewed. The study was carried out at the King Khaled Eye Specialist Hospital and The Eye Center in Riyadh, Saudi Arabia. Investigators recorded the age, gender, history of trauma, associated systemic disorders, and ocular and systemic manifestations. Patients were examined by an ophthalmologist as well as an internist.
Results
A total of 316 patients were included: 256 patients had VKH and 60 patients had SO. The age range in the VKH group was 3–62 years with a mean age of 29 ± 13 years. The age range in the SO group was 4–90 years with a mean age of 36 ± 20 years. The mean follow-up period of patients with VKH was 58 ± 50 months and patients with SO was 61 ± 54 months. Out of 256 patients with VKH, there were 41 (16%) with systemic disorders. Comparatively, out of 60 patients with SO, no associated systemic autoimmune disorders or tumors were encountered. The difference between the VKH and SO groups was statistically significant (
p
= 0.003).
Conclusions
VKH and SO are autoimmune disorders targeting melanin-bearing cells. Both diseases are characterized by immunologic dysregulation. We found a statistically significant association of systemic disorders and malignancy with VKH compared to SO. This finding may suggest that the two disorders may have different etiology with similar ocular and systemic manifestations.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Autoimmune Diseases - complications</subject><subject>Autoimmune Diseases - diagnosis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Eye Diseases - complications</subject><subject>Eye Diseases - diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory Disorders</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - diagnosis</subject><subject>Ophthalmia, Sympathetic - complications</subject><subject>Ophthalmia, Sympathetic - diagnosis</subject><subject>Ophthalmology</subject><subject>Retrospective Studies</subject><subject>Uveomeningoencephalitic Syndrome - complications</subject><subject>Uveomeningoencephalitic Syndrome - diagnosis</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kM1OGzEURq2qqATaB-gGjbphNeA79sSeZYWgoCKxgSqrWjf-yRhlxqntCGXXd-gb8iQYJQUJCXlxLd3zfbYOIV-BngCl4jRRykHUFKAG0YiafyAT4KytBW1mH8mEigZqyZrZPjlI6Z4WnLXwiew3IMqRdEJ-3_a2wpSC9ph9GKvgqrRJ2Q5eV8anEI2NqXrwua9-hUV-_PvvZ9jgiAtfrpcY0WCFoymhYYW5t7nkwqrPPS4Hj5_JnsNlsl9285DcXZzfnl3W1zc_rs6-X9eaCZprg2IOnRFWADhuJXPdlEnNBbdCW5h3iBy4k12noXNm2jbOcD53bGq0kLplh-R427uK4c_apqwGn7RdLnG0YZ2U7FgzbZnoCvntDXkf1nEsn1NSAmtZQQsEW0jHkFK0Tq2iHzBuFFD1rF5t1auiXj2rV7xkjnbF6_lgzUviv-sCNFsgldW4sPH15fdbnwAij5Gc</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Al-Halafi, Ali</creator><creator>Dhibi, Hassan Al</creator><creator>Hamade, Issam H.</creator><creator>Bou Chacra, Charbel T.</creator><creator>Tabbara, Khalid F.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>The association of systemic disorders with Vogt–Koyanagi–Harada and sympathetic ophthalmia</title><author>Al-Halafi, Ali ; Dhibi, Hassan Al ; Hamade, Issam H. ; Bou Chacra, Charbel T. ; Tabbara, Khalid F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-da7b19d7e711f4e83f9638c474e7ce1b9aa414f899c19fd652fd44bf36dc78c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Autoimmune Diseases - complications</topic><topic>Autoimmune Diseases - diagnosis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Eye Diseases - complications</topic><topic>Eye Diseases - diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammatory Disorders</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - diagnosis</topic><topic>Ophthalmia, Sympathetic - complications</topic><topic>Ophthalmia, Sympathetic - diagnosis</topic><topic>Ophthalmology</topic><topic>Retrospective Studies</topic><topic>Uveomeningoencephalitic Syndrome - complications</topic><topic>Uveomeningoencephalitic Syndrome - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Halafi, Ali</creatorcontrib><creatorcontrib>Dhibi, Hassan Al</creatorcontrib><creatorcontrib>Hamade, Issam H.</creatorcontrib><creatorcontrib>Bou Chacra, Charbel T.</creatorcontrib><creatorcontrib>Tabbara, Khalid F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Halafi, Ali</au><au>Dhibi, Hassan Al</au><au>Hamade, Issam H.</au><au>Bou Chacra, Charbel T.</au><au>Tabbara, Khalid F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of systemic disorders with Vogt–Koyanagi–Harada and sympathetic ophthalmia</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>249</volume><issue>8</issue><spage>1229</spage><epage>1233</epage><pages>1229-1233</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Background
The aim of this work is to determine the systemic diseases and malignancy associated with Vogt–Koyanagi–Harada (VKH) disease compared to sympathetic ophthalmia (SO).
Methods
We conducted a retrospective comparative observational clinical study where the medical records of patients with the diagnosis of VKH and SO from 1999–2009 were reviewed. The study was carried out at the King Khaled Eye Specialist Hospital and The Eye Center in Riyadh, Saudi Arabia. Investigators recorded the age, gender, history of trauma, associated systemic disorders, and ocular and systemic manifestations. Patients were examined by an ophthalmologist as well as an internist.
Results
A total of 316 patients were included: 256 patients had VKH and 60 patients had SO. The age range in the VKH group was 3–62 years with a mean age of 29 ± 13 years. The age range in the SO group was 4–90 years with a mean age of 36 ± 20 years. The mean follow-up period of patients with VKH was 58 ± 50 months and patients with SO was 61 ± 54 months. Out of 256 patients with VKH, there were 41 (16%) with systemic disorders. Comparatively, out of 60 patients with SO, no associated systemic autoimmune disorders or tumors were encountered. The difference between the VKH and SO groups was statistically significant (
p
= 0.003).
Conclusions
VKH and SO are autoimmune disorders targeting melanin-bearing cells. Both diseases are characterized by immunologic dysregulation. We found a statistically significant association of systemic disorders and malignancy with VKH compared to SO. This finding may suggest that the two disorders may have different etiology with similar ocular and systemic manifestations.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21717180</pmid><doi>10.1007/s00417-011-1727-4</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2011-08, Vol.249 (8), p.1229-1233 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Autoimmune Diseases - complications Autoimmune Diseases - diagnosis Child Child, Preschool Eye Diseases - complications Eye Diseases - diagnosis Female Humans Inflammatory Disorders Male Medicine Medicine & Public Health Middle Aged Neoplasms - complications Neoplasms - diagnosis Ophthalmia, Sympathetic - complications Ophthalmia, Sympathetic - diagnosis Ophthalmology Retrospective Studies Uveomeningoencephalitic Syndrome - complications Uveomeningoencephalitic Syndrome - diagnosis |
| title | The association of systemic disorders with Vogt–Koyanagi–Harada and sympathetic ophthalmia |
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