Antimicrobial activity of the Naja atra cathelicidin and related small peptides

We have identified an 11-residue pattern (KR(F/A)KKFFKK(L/P)K), which we have named the ATRA motif, within the sequence of the Chinese cobra ( Naja atra) cathelicidin. A series of 11-residue peptides (ATRA-1, -2, -1A and -1P) were designed to probe the significance of the conserved residues within t...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-06, Vol.396 (4), p.825-830
Hauptverfasser:	de Latour, Frank A., Amer, Lilian S., Papanstasiou, Emilios A., Bishop, Barney M., Hoek, Monique L. van
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Animals Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptide Cathelicidin Elapidae - metabolism Escherichia coli Escherichia coli - drug effects Helical Molecular Sequence Data Naja Oligopeptides - chemistry Oligopeptides - pharmacology Pasteurellaceae - drug effects Peptide Fragments - chemistry Peptide Fragments - pharmacology
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