Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease

Background & Aims We applied a metabolome profiling approach to serum samples obtained from patients with different liver diseases, to discover noninvasive and reliable biomarkers for rapid-screening diagnosis of liver diseases. Methods Using capillary electrophoresis and liquid chromatography m...

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Veröffentlicht in:	Journal of hepatology 2011-10, Vol.55 (4), p.896-905
Hauptverfasser:	Soga, Tomoyoshi, Sugimoto, Masahiro, Honma, Masashi, Mori, Masayo, Igarashi, Kaori, Kashikura, Kasumi, Ikeda, Satsuki, Hirayama, Akiyoshi, Yamamoto, Takehito, Yoshida, Haruhiko, Otsuka, Motoyuki, Tsuji, Shoji, Yatomi, Yutaka, Sakuragawa, Tadayuki, Watanabe, Hisayoshi, Nihei, Kouei, Saito, Takafumi, Kawata, Sumio, Suzuki, Hiroshi, Tomita, Masaru, Suematsu, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Biomarker Biomarkers - blood Capillary electrophoresis mass spectrometry Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnosis Diagnosis, Differential Dipeptides - blood Fatty Liver - blood Fatty Liver - diagnosis Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Glutamine - blood Glutathione Hepatitis B, Chronic - blood Hepatitis B, Chronic - diagnosis Hepatitis C virus Hepatitis C, Chronic - blood Hepatitis C, Chronic - diagnosis Hepatocellular carcinoma Humans Liver Cirrhosis - blood Liver Cirrhosis - diagnosis Liver Diseases - blood Liver Diseases - diagnosis Liver Neoplasms - blood Liver Neoplasms - diagnosis Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Metabolomics Metabolomics - methods Metabolomics - standards Middle Aged Non-alcoholic Fatty Liver Disease Nonalcoholic steatohepatitis Oxidative stress Oxidative Stress - physiology Protein Array Analysis - methods Protein Array Analysis - standards Reproducibility of Results Tumors γ-Glutamyl dipeptides
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