Prognostic implications of lymph node metastases in carcinoma of the body and tail of the pancreas
The current classification of pancreatic cancer is based only on anatomic location of metastatic lymph nodes (LNs). On the other hand, the number of metastatic LNs has been used in staging of colorectal, esophageal, and gastric cancers. The aim of this study was to assess the prognostic impact of th...
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| Veröffentlicht in: | Pancreas 2011-10, Vol.40 (7), p.1029-1033 |
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| creator | Sahin, Tevfik T Fujii, Tsutomu Kanda, Mitsuro Nagai, Shunji Kodera, Yasuhiro Kanzaki, Akiyuki Yamamura, Kazuo Sugimoto, Hiroyuki Kasuya, Hideki Nomoto, Shuji Takeda, Shin Morita, Satoshi Nakao, Akimasa |
| description | The current classification of pancreatic cancer is based only on anatomic location of metastatic lymph nodes (LNs). On the other hand, the number of metastatic LNs has been used in staging of colorectal, esophageal, and gastric cancers. The aim of this study was to assess the prognostic impact of the number or ratio of the metastatic LNs in pancreatic body and tail carcinoma.
Eighty-five patients with pancreatic body and tail adenocarcinoma who underwent pancreatectomy were included. Location, number, ratio of metastatic LNs, and the survival of patients were analyzed.
Forty patients with LN metastasis had poor prognosis (P = 0.007). The prognoses of patients with 5 or more metastatic LNs were poorer than those with less than 5 metastatic LNs (P = 0.046), and patients with a metastatic LN ratio of 0.2 or more had the worst prognosis. Multivariate analysis revealed that 5 or more metastatic LNs and metastatic LN ratio of 0.2 or more were independent prognostic factors for survival (P = 0.0015 and P = 0.014, respectively).
These results indicate that the number and the ratio of metastatic LNs can be used to predict poor patient survival and as a staging strategy. |
| doi_str_mv | 10.1097/MPA.0b013e3182207893 |
| format | Article |
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Eighty-five patients with pancreatic body and tail adenocarcinoma who underwent pancreatectomy were included. Location, number, ratio of metastatic LNs, and the survival of patients were analyzed.
Forty patients with LN metastasis had poor prognosis (P = 0.007). The prognoses of patients with 5 or more metastatic LNs were poorer than those with less than 5 metastatic LNs (P = 0.046), and patients with a metastatic LN ratio of 0.2 or more had the worst prognosis. Multivariate analysis revealed that 5 or more metastatic LNs and metastatic LN ratio of 0.2 or more were independent prognostic factors for survival (P = 0.0015 and P = 0.014, respectively).
These results indicate that the number and the ratio of metastatic LNs can be used to predict poor patient survival and as a staging strategy.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/MPA.0b013e3182207893</identifier><identifier>PMID: 21705947</identifier><language>eng</language><publisher>United States</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - secondary ; Adenocarcinoma - surgery ; Adult ; Aged ; Chi-Square Distribution ; Female ; Humans ; Japan ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Pancreatectomy ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Proportional Hazards Models ; Risk Assessment ; Risk Factors ; Survival Rate ; Time Factors ; Treatment Outcome</subject><ispartof>Pancreas, 2011-10, Vol.40 (7), p.1029-1033</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-8086dbf1f6835afa839dd9ffb6946c0e2b6f8ff15c1f88309b19b8f48d50bc3b3</citedby><cites>FETCH-LOGICAL-c372t-8086dbf1f6835afa839dd9ffb6946c0e2b6f8ff15c1f88309b19b8f48d50bc3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21705947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sahin, Tevfik T</creatorcontrib><creatorcontrib>Fujii, Tsutomu</creatorcontrib><creatorcontrib>Kanda, Mitsuro</creatorcontrib><creatorcontrib>Nagai, Shunji</creatorcontrib><creatorcontrib>Kodera, Yasuhiro</creatorcontrib><creatorcontrib>Kanzaki, Akiyuki</creatorcontrib><creatorcontrib>Yamamura, Kazuo</creatorcontrib><creatorcontrib>Sugimoto, Hiroyuki</creatorcontrib><creatorcontrib>Kasuya, Hideki</creatorcontrib><creatorcontrib>Nomoto, Shuji</creatorcontrib><creatorcontrib>Takeda, Shin</creatorcontrib><creatorcontrib>Morita, Satoshi</creatorcontrib><creatorcontrib>Nakao, Akimasa</creatorcontrib><title>Prognostic implications of lymph node metastases in carcinoma of the body and tail of the pancreas</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>The current classification of pancreatic cancer is based only on anatomic location of metastatic lymph nodes (LNs). On the other hand, the number of metastatic LNs has been used in staging of colorectal, esophageal, and gastric cancers. The aim of this study was to assess the prognostic impact of the number or ratio of the metastatic LNs in pancreatic body and tail carcinoma.
Eighty-five patients with pancreatic body and tail adenocarcinoma who underwent pancreatectomy were included. Location, number, ratio of metastatic LNs, and the survival of patients were analyzed.
Forty patients with LN metastasis had poor prognosis (P = 0.007). The prognoses of patients with 5 or more metastatic LNs were poorer than those with less than 5 metastatic LNs (P = 0.046), and patients with a metastatic LN ratio of 0.2 or more had the worst prognosis. Multivariate analysis revealed that 5 or more metastatic LNs and metastatic LN ratio of 0.2 or more were independent prognostic factors for survival (P = 0.0015 and P = 0.014, respectively).
These results indicate that the number and the ratio of metastatic LNs can be used to predict poor patient survival and as a staging strategy.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Chi-Square Distribution</subject><subject>Female</subject><subject>Humans</subject><subject>Japan</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Pancreatectomy</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Proportional Hazards Models</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1LAzEQhoMotlb_gUhunrYmm81mcizFL6jYg56XfNrI7mbdbA_9925p60EYeGF43hl4ELqlZE6JFA9v68WcaEKZYxTynAiQ7AxNKWdlVkAO52hKAHjGqBATdJXSNyFUMC4v0SSngnBZiCnS6z5-tTENweDQdHUwagixTTh6XO-aboPbaB1u3KDSOC7h0GKjehPa2Kg9NWwc1tHusGotHlSoT8tOtaZ3Kl2jC6_q5G6OOUOfT48fy5ds9f78ulysMsNEPmRAoLTaU18C48orYNJa6b0uZVEa4nJdevCeckM9ACNSU6nBF2A50YZpNkP3h7tdH3-2Lg1VE5Jxda1aF7epApnLAjiXI1kcSNPHlHrnq64Pjep3FSXVXm41yq3-yx1rd8cHW904-1c62WS_12Z3Ng</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Sahin, Tevfik T</creator><creator>Fujii, Tsutomu</creator><creator>Kanda, Mitsuro</creator><creator>Nagai, Shunji</creator><creator>Kodera, Yasuhiro</creator><creator>Kanzaki, Akiyuki</creator><creator>Yamamura, Kazuo</creator><creator>Sugimoto, Hiroyuki</creator><creator>Kasuya, Hideki</creator><creator>Nomoto, Shuji</creator><creator>Takeda, Shin</creator><creator>Morita, Satoshi</creator><creator>Nakao, Akimasa</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Prognostic implications of lymph node metastases in carcinoma of the body and tail of the pancreas</title><author>Sahin, Tevfik T ; Fujii, Tsutomu ; Kanda, Mitsuro ; Nagai, Shunji ; Kodera, Yasuhiro ; Kanzaki, Akiyuki ; Yamamura, Kazuo ; Sugimoto, Hiroyuki ; Kasuya, Hideki ; Nomoto, Shuji ; Takeda, Shin ; Morita, Satoshi ; Nakao, Akimasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-8086dbf1f6835afa839dd9ffb6946c0e2b6f8ff15c1f88309b19b8f48d50bc3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - secondary</topic><topic>Adenocarcinoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Chi-Square Distribution</topic><topic>Female</topic><topic>Humans</topic><topic>Japan</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Pancreatectomy</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Proportional Hazards Models</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sahin, Tevfik T</creatorcontrib><creatorcontrib>Fujii, Tsutomu</creatorcontrib><creatorcontrib>Kanda, Mitsuro</creatorcontrib><creatorcontrib>Nagai, Shunji</creatorcontrib><creatorcontrib>Kodera, Yasuhiro</creatorcontrib><creatorcontrib>Kanzaki, Akiyuki</creatorcontrib><creatorcontrib>Yamamura, Kazuo</creatorcontrib><creatorcontrib>Sugimoto, Hiroyuki</creatorcontrib><creatorcontrib>Kasuya, Hideki</creatorcontrib><creatorcontrib>Nomoto, Shuji</creatorcontrib><creatorcontrib>Takeda, Shin</creatorcontrib><creatorcontrib>Morita, Satoshi</creatorcontrib><creatorcontrib>Nakao, Akimasa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sahin, Tevfik T</au><au>Fujii, Tsutomu</au><au>Kanda, Mitsuro</au><au>Nagai, Shunji</au><au>Kodera, Yasuhiro</au><au>Kanzaki, Akiyuki</au><au>Yamamura, Kazuo</au><au>Sugimoto, Hiroyuki</au><au>Kasuya, Hideki</au><au>Nomoto, Shuji</au><au>Takeda, Shin</au><au>Morita, Satoshi</au><au>Nakao, Akimasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic implications of lymph node metastases in carcinoma of the body and tail of the pancreas</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>2011-10</date><risdate>2011</risdate><volume>40</volume><issue>7</issue><spage>1029</spage><epage>1033</epage><pages>1029-1033</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><abstract>The current classification of pancreatic cancer is based only on anatomic location of metastatic lymph nodes (LNs). On the other hand, the number of metastatic LNs has been used in staging of colorectal, esophageal, and gastric cancers. The aim of this study was to assess the prognostic impact of the number or ratio of the metastatic LNs in pancreatic body and tail carcinoma.
Eighty-five patients with pancreatic body and tail adenocarcinoma who underwent pancreatectomy were included. Location, number, ratio of metastatic LNs, and the survival of patients were analyzed.
Forty patients with LN metastasis had poor prognosis (P = 0.007). The prognoses of patients with 5 or more metastatic LNs were poorer than those with less than 5 metastatic LNs (P = 0.046), and patients with a metastatic LN ratio of 0.2 or more had the worst prognosis. Multivariate analysis revealed that 5 or more metastatic LNs and metastatic LN ratio of 0.2 or more were independent prognostic factors for survival (P = 0.0015 and P = 0.014, respectively).
These results indicate that the number and the ratio of metastatic LNs can be used to predict poor patient survival and as a staging strategy.</abstract><cop>United States</cop><pmid>21705947</pmid><doi>10.1097/MPA.0b013e3182207893</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenocarcinoma - mortality Adenocarcinoma - secondary Adenocarcinoma - surgery Adult Aged Chi-Square Distribution Female Humans Japan Kaplan-Meier Estimate Lymphatic Metastasis Male Middle Aged Neoplasm Staging Pancreatectomy Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Proportional Hazards Models Risk Assessment Risk Factors Survival Rate Time Factors Treatment Outcome |
| title | Prognostic implications of lymph node metastases in carcinoma of the body and tail of the pancreas |
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