Intramuscular botulinum toxin in complex regional pain syndrome: case series and literature review
Pain associated with Complex Regional Pain Syndrome (CRPS) is frequently excruciating and intractable. The use of botulinum toxin for relief of CRPS-associated pain has not been well described. To assess whether intramuscular botulinum toxin injections cause relief of pain caused by CRPS, and to ass...
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| Veröffentlicht in: | Pain physician 2011-09, Vol.14 (5), p.419-424 |
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| creator | Kharkar, Siddharth Ambady, Prakash Venkatesh, Yedatore Schwartzman, Robert J |
| description | Pain associated with Complex Regional Pain Syndrome (CRPS) is frequently excruciating and intractable. The use of botulinum toxin for relief of CRPS-associated pain has not been well described.
To assess whether intramuscular botulinum toxin injections cause relief of pain caused by CRPS, and to assess the risks of this treatment.
Retrospective chart review.
Outpatient clinic.
37 patients with spasm/dystonia in the neck and/or upper limb girdle muscles.
EMG-guided injection of Botulinum Toxin - A (BtxA), 10-20 units per muscle. Total dose used was 100 units in each patient. Local pain score was measured on an 11-point Likert scale, 4 weeks after BtxA injections.
Mean pain score decreased by 43% (8.2 ± 0.8 to 4.5 ± 1.1, P < 0.001). 97% patients had significant pain relief. One patient had transient neck drop after the injections.
This is a retrospective study, it lacks a control group and hence the placebo effect cannot be eliminated. This study does not provide information on the efficacy of this treatment after 4 weeks.
Intramuscular injection of botulinum toxin in the upper limb girdle muscles was beneficial for short term relief of pain caused by CRPS. The incidence of complications was low (2.7%). |
| doi_str_mv | 10.36076/ppj.2011/14/419 |
| format | Article |
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To assess whether intramuscular botulinum toxin injections cause relief of pain caused by CRPS, and to assess the risks of this treatment.
Retrospective chart review.
Outpatient clinic.
37 patients with spasm/dystonia in the neck and/or upper limb girdle muscles.
EMG-guided injection of Botulinum Toxin - A (BtxA), 10-20 units per muscle. Total dose used was 100 units in each patient. Local pain score was measured on an 11-point Likert scale, 4 weeks after BtxA injections.
Mean pain score decreased by 43% (8.2 ± 0.8 to 4.5 ± 1.1, P < 0.001). 97% patients had significant pain relief. One patient had transient neck drop after the injections.
This is a retrospective study, it lacks a control group and hence the placebo effect cannot be eliminated. This study does not provide information on the efficacy of this treatment after 4 weeks.
Intramuscular injection of botulinum toxin in the upper limb girdle muscles was beneficial for short term relief of pain caused by CRPS. The incidence of complications was low (2.7%).</description><identifier>ISSN: 1533-3159</identifier><identifier>EISSN: 2150-1149</identifier><identifier>DOI: 10.36076/ppj.2011/14/419</identifier><identifier>PMID: 21927045</identifier><language>eng</language><publisher>United States: American Society of Interventional Pain Physician</publisher><subject>Botulinum toxin ; Botulinum Toxins, Type A - therapeutic use ; Complex Regional Pain Syndromes - classification ; Complex Regional Pain Syndromes - drug therapy ; Electromyography ; Female ; Humans ; Injections, Intramuscular ; Likelihood Functions ; Male ; Neuromuscular Agents - therapeutic use ; Pain ; Pain Measurement ; Peptide Fragments - therapeutic use ; Retrospective Studies</subject><ispartof>Pain physician, 2011-09, Vol.14 (5), p.419-424</ispartof><rights>2011. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-403827a7ceffa000ff1814b770298c1288bf25fd04829d27fb80ce235ea243873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21927045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kharkar, Siddharth</creatorcontrib><creatorcontrib>Ambady, Prakash</creatorcontrib><creatorcontrib>Venkatesh, Yedatore</creatorcontrib><creatorcontrib>Schwartzman, Robert J</creatorcontrib><title>Intramuscular botulinum toxin in complex regional pain syndrome: case series and literature review</title><title>Pain physician</title><addtitle>Pain Physician</addtitle><description>Pain associated with Complex Regional Pain Syndrome (CRPS) is frequently excruciating and intractable. The use of botulinum toxin for relief of CRPS-associated pain has not been well described.
To assess whether intramuscular botulinum toxin injections cause relief of pain caused by CRPS, and to assess the risks of this treatment.
Retrospective chart review.
Outpatient clinic.
37 patients with spasm/dystonia in the neck and/or upper limb girdle muscles.
EMG-guided injection of Botulinum Toxin - A (BtxA), 10-20 units per muscle. Total dose used was 100 units in each patient. Local pain score was measured on an 11-point Likert scale, 4 weeks after BtxA injections.
Mean pain score decreased by 43% (8.2 ± 0.8 to 4.5 ± 1.1, P < 0.001). 97% patients had significant pain relief. One patient had transient neck drop after the injections.
This is a retrospective study, it lacks a control group and hence the placebo effect cannot be eliminated. This study does not provide information on the efficacy of this treatment after 4 weeks.
Intramuscular injection of botulinum toxin in the upper limb girdle muscles was beneficial for short term relief of pain caused by CRPS. 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Ambady, Prakash ; Venkatesh, Yedatore ; Schwartzman, Robert J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-403827a7ceffa000ff1814b770298c1288bf25fd04829d27fb80ce235ea243873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Botulinum toxin</topic><topic>Botulinum Toxins, Type A - therapeutic use</topic><topic>Complex Regional Pain Syndromes - classification</topic><topic>Complex Regional Pain Syndromes - drug therapy</topic><topic>Electromyography</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Intramuscular</topic><topic>Likelihood Functions</topic><topic>Male</topic><topic>Neuromuscular Agents - therapeutic use</topic><topic>Pain</topic><topic>Pain Measurement</topic><topic>Peptide Fragments - therapeutic use</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kharkar, Siddharth</creatorcontrib><creatorcontrib>Ambady, Prakash</creatorcontrib><creatorcontrib>Venkatesh, Yedatore</creatorcontrib><creatorcontrib>Schwartzman, Robert J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pain physician</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kharkar, Siddharth</au><au>Ambady, Prakash</au><au>Venkatesh, Yedatore</au><au>Schwartzman, Robert J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intramuscular botulinum toxin in complex regional pain syndrome: case series and literature review</atitle><jtitle>Pain physician</jtitle><addtitle>Pain Physician</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>14</volume><issue>5</issue><spage>419</spage><epage>424</epage><pages>419-424</pages><issn>1533-3159</issn><eissn>2150-1149</eissn><abstract>Pain associated with Complex Regional Pain Syndrome (CRPS) is frequently excruciating and intractable. The use of botulinum toxin for relief of CRPS-associated pain has not been well described.
To assess whether intramuscular botulinum toxin injections cause relief of pain caused by CRPS, and to assess the risks of this treatment.
Retrospective chart review.
Outpatient clinic.
37 patients with spasm/dystonia in the neck and/or upper limb girdle muscles.
EMG-guided injection of Botulinum Toxin - A (BtxA), 10-20 units per muscle. Total dose used was 100 units in each patient. Local pain score was measured on an 11-point Likert scale, 4 weeks after BtxA injections.
Mean pain score decreased by 43% (8.2 ± 0.8 to 4.5 ± 1.1, P < 0.001). 97% patients had significant pain relief. One patient had transient neck drop after the injections.
This is a retrospective study, it lacks a control group and hence the placebo effect cannot be eliminated. This study does not provide information on the efficacy of this treatment after 4 weeks.
Intramuscular injection of botulinum toxin in the upper limb girdle muscles was beneficial for short term relief of pain caused by CRPS. The incidence of complications was low (2.7%).</abstract><cop>United States</cop><pub>American Society of Interventional Pain Physician</pub><pmid>21927045</pmid><doi>10.36076/ppj.2011/14/419</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Botulinum toxin Botulinum Toxins, Type A - therapeutic use Complex Regional Pain Syndromes - classification Complex Regional Pain Syndromes - drug therapy Electromyography Female Humans Injections, Intramuscular Likelihood Functions Male Neuromuscular Agents - therapeutic use Pain Pain Measurement Peptide Fragments - therapeutic use Retrospective Studies |
| title | Intramuscular botulinum toxin in complex regional pain syndrome: case series and literature review |
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