Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon
Background. Proteinuria during pregnancy has been associated with increased pregnancy complications. Furthermore, even low-grade proteinuria has been associated with increased mortality in the general population and in non-pregnant HIV-infected women. Methods. Urine dipstick protein was measured pro...
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| creator | Jao, Jennifer Palmer, Dennis Leus, Ine Tih, Pius Baweja, Mukta Klotman, Mary Sperling, Rhoda Wyatt, Christina |
| description | Background. Proteinuria during pregnancy has been associated with increased pregnancy complications. Furthermore, even low-grade proteinuria has been associated with increased mortality in the general population and in non-pregnant HIV-infected women.
Methods. Urine dipstick protein was measured prospectively on HIV-infected and trace protein or more and quantified by urine protein:creatinine measurement (P:C). Logistic regression modeling was used to identify factors associated with proteinuria.
Results. About 199 human immunodeficiency virus (HIV)-infected and 190 HIV-uninfected normotensive pregnant women were evaluated. The median age was 27 years in both groups and 37% presented in the third trimester. Among HIV-infected women, median CD4 cell count was 417 cells/mm3; 27% were on combination antiretroviral therapy (cART). Proteinuria was present in 39.2% of HIV-infected and 20.9% of uninfected women (P < 0.001). HIV infection was independently associated with proteinuria [adjusted odds ratio (OR) = 2.45; confidence interval (CI) = 1.56-3.85]. Among HIV-infected pregnant women, cART was protective (adjusted OR = 0.39; CI = 0.19-0.82). Results were qualitatively similar when urine P:C was evaluated as a continuous outcome variable.
Conclusions. The prevalence of low-grade proteinuria in both HIV-infected and -uninfected Cameroonian pregnant women is high. HIV-infected pregnant women are at increased risk for proteinuria, and cART appears to exert a protective effect. Further studies are needed to elucidate the causes of increased proteinuria in African pregnant women, both HIV-infected and -uninfected. |
| doi_str_mv | 10.1093/ndt/gfr310 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_892948012</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ndt/gfr310</oup_id><sourcerecordid>892948012</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-e54a1ec2c764df16291b93aa37f5ddb33a4b41c84a45cdd7d9d505a44bb19bab3</originalsourceid><addsrcrecordid>eNp90Mtq3DAUBmBRGjrTJJs-QPGmNBSc6GpbyzDkBoFk0WRrjqTjwcWWppKd0rev0plkdrMSB33nwk_IF0bPGdXiwrvpYt1FwegHsmSyoiUXjfpIlvmTlVRRvSCfU_pFKdW8rj-RBWc10zUTS2IeI77AgN5iAd4Vm4iut1OIqQhdrsKEvZ9jD0Xvi9u757L3HdoJ3X89-_cyN649-Kn4E0b0r3oFI8YQ_Ak56mBIeLp7j8nT9dXP1W15_3Bzt7q8L61kaipRSWBoua0r6TpWcc2MFgCi7pRzRgiQRjLbSJDKOlc77RRVIKUxTBsw4ph8387NV_-eMU3t2CeLwwAew5zaRnMtG8p4lmcHJaOcNqJphMj0x5baGFKK2LWb2I8Q_2bUvqbf5vTbbfoZf93Nnc2I7p2-xZ3Btx2AZGHoInjbp72TqlIVr_YuzJtDC_8BlRWbWw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1020838833</pqid></control><display><type>article</type><title>Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Jao, Jennifer ; Palmer, Dennis ; Leus, Ine ; Tih, Pius ; Baweja, Mukta ; Klotman, Mary ; Sperling, Rhoda ; Wyatt, Christina</creator><creatorcontrib>Jao, Jennifer ; Palmer, Dennis ; Leus, Ine ; Tih, Pius ; Baweja, Mukta ; Klotman, Mary ; Sperling, Rhoda ; Wyatt, Christina</creatorcontrib><description>Background. Proteinuria during pregnancy has been associated with increased pregnancy complications. Furthermore, even low-grade proteinuria has been associated with increased mortality in the general population and in non-pregnant HIV-infected women.
Methods. Urine dipstick protein was measured prospectively on HIV-infected and trace protein or more and quantified by urine protein:creatinine measurement (P:C). Logistic regression modeling was used to identify factors associated with proteinuria.
Results. About 199 human immunodeficiency virus (HIV)-infected and 190 HIV-uninfected normotensive pregnant women were evaluated. The median age was 27 years in both groups and 37% presented in the third trimester. Among HIV-infected women, median CD4 cell count was 417 cells/mm3; 27% were on combination antiretroviral therapy (cART). Proteinuria was present in 39.2% of HIV-infected and 20.9% of uninfected women (P < 0.001). HIV infection was independently associated with proteinuria [adjusted odds ratio (OR) = 2.45; confidence interval (CI) = 1.56-3.85]. Among HIV-infected pregnant women, cART was protective (adjusted OR = 0.39; CI = 0.19-0.82). Results were qualitatively similar when urine P:C was evaluated as a continuous outcome variable.
Conclusions. The prevalence of low-grade proteinuria in both HIV-infected and -uninfected Cameroonian pregnant women is high. HIV-infected pregnant women are at increased risk for proteinuria, and cART appears to exert a protective effect. Further studies are needed to elucidate the causes of increased proteinuria in African pregnant women, both HIV-infected and -uninfected.</description><identifier>ISSN: 0931-0509</identifier><identifier>EISSN: 1460-2385</identifier><identifier>DOI: 10.1093/ndt/gfr310</identifier><identifier>PMID: 21719713</identifier><identifier>CODEN: NDTREA</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Age ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; antiretroviral therapy ; Antiretroviral Therapy, Highly Active ; Biological and medical sciences ; Cameroon - epidemiology ; Case-Control Studies ; CD4 antigen ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Follow-Up Studies ; HIV Infections - complications ; HIV Infections - epidemiology ; HIV Infections - transmission ; HIV-1 - pathogenicity ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infection ; Infectious diseases ; Intensive care medicine ; Medical sciences ; Mortality ; Pregnancy ; Pregnancy complications ; Pregnancy Complications, Infectious - diagnosis ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Complications, Infectious - etiology ; Prevalence ; Prognosis ; Proteinuria ; Proteinuria - diagnosis ; Proteinuria - epidemiology ; Proteinuria - etiology ; Survival Rate ; Urine ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Young Adult</subject><ispartof>Nephrology, dialysis, transplantation, 2011-09, Vol.26 (9), p.3051-3053</ispartof><rights>The Author 2011. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-e54a1ec2c764df16291b93aa37f5ddb33a4b41c84a45cdd7d9d505a44bb19bab3</citedby><cites>FETCH-LOGICAL-c415t-e54a1ec2c764df16291b93aa37f5ddb33a4b41c84a45cdd7d9d505a44bb19bab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24565626$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21719713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jao, Jennifer</creatorcontrib><creatorcontrib>Palmer, Dennis</creatorcontrib><creatorcontrib>Leus, Ine</creatorcontrib><creatorcontrib>Tih, Pius</creatorcontrib><creatorcontrib>Baweja, Mukta</creatorcontrib><creatorcontrib>Klotman, Mary</creatorcontrib><creatorcontrib>Sperling, Rhoda</creatorcontrib><creatorcontrib>Wyatt, Christina</creatorcontrib><title>Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon</title><title>Nephrology, dialysis, transplantation</title><addtitle>Nephrol Dial Transplant</addtitle><description>Background. Proteinuria during pregnancy has been associated with increased pregnancy complications. Furthermore, even low-grade proteinuria has been associated with increased mortality in the general population and in non-pregnant HIV-infected women.
Methods. Urine dipstick protein was measured prospectively on HIV-infected and trace protein or more and quantified by urine protein:creatinine measurement (P:C). Logistic regression modeling was used to identify factors associated with proteinuria.
Results. About 199 human immunodeficiency virus (HIV)-infected and 190 HIV-uninfected normotensive pregnant women were evaluated. The median age was 27 years in both groups and 37% presented in the third trimester. Among HIV-infected women, median CD4 cell count was 417 cells/mm3; 27% were on combination antiretroviral therapy (cART). Proteinuria was present in 39.2% of HIV-infected and 20.9% of uninfected women (P < 0.001). HIV infection was independently associated with proteinuria [adjusted odds ratio (OR) = 2.45; confidence interval (CI) = 1.56-3.85]. Among HIV-infected pregnant women, cART was protective (adjusted OR = 0.39; CI = 0.19-0.82). Results were qualitatively similar when urine P:C was evaluated as a continuous outcome variable.
Conclusions. The prevalence of low-grade proteinuria in both HIV-infected and -uninfected Cameroonian pregnant women is high. HIV-infected pregnant women are at increased risk for proteinuria, and cART appears to exert a protective effect. Further studies are needed to elucidate the causes of increased proteinuria in African pregnant women, both HIV-infected and -uninfected.</description><subject>Adult</subject><subject>Age</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>antiretroviral therapy</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Biological and medical sciences</subject><subject>Cameroon - epidemiology</subject><subject>Case-Control Studies</subject><subject>CD4 antigen</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - transmission</subject><subject>HIV-1 - pathogenicity</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infection</subject><subject>Infectious diseases</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Pregnancy Complications, Infectious - diagnosis</subject><subject>Pregnancy Complications, Infectious - epidemiology</subject><subject>Pregnancy Complications, Infectious - etiology</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Proteinuria</subject><subject>Proteinuria - diagnosis</subject><subject>Proteinuria - epidemiology</subject><subject>Proteinuria - etiology</subject><subject>Survival Rate</subject><subject>Urine</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Young Adult</subject><issn>0931-0509</issn><issn>1460-2385</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90Mtq3DAUBmBRGjrTJJs-QPGmNBSc6GpbyzDkBoFk0WRrjqTjwcWWppKd0rev0plkdrMSB33nwk_IF0bPGdXiwrvpYt1FwegHsmSyoiUXjfpIlvmTlVRRvSCfU_pFKdW8rj-RBWc10zUTS2IeI77AgN5iAd4Vm4iut1OIqQhdrsKEvZ9jD0Xvi9u757L3HdoJ3X89-_cyN649-Kn4E0b0r3oFI8YQ_Ak56mBIeLp7j8nT9dXP1W15_3Bzt7q8L61kaipRSWBoua0r6TpWcc2MFgCi7pRzRgiQRjLbSJDKOlc77RRVIKUxTBsw4ph8387NV_-eMU3t2CeLwwAew5zaRnMtG8p4lmcHJaOcNqJphMj0x5baGFKK2LWb2I8Q_2bUvqbf5vTbbfoZf93Nnc2I7p2-xZ3Btx2AZGHoInjbp72TqlIVr_YuzJtDC_8BlRWbWw</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Jao, Jennifer</creator><creator>Palmer, Dennis</creator><creator>Leus, Ine</creator><creator>Tih, Pius</creator><creator>Baweja, Mukta</creator><creator>Klotman, Mary</creator><creator>Sperling, Rhoda</creator><creator>Wyatt, Christina</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon</title><author>Jao, Jennifer ; Palmer, Dennis ; Leus, Ine ; Tih, Pius ; Baweja, Mukta ; Klotman, Mary ; Sperling, Rhoda ; Wyatt, Christina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-e54a1ec2c764df16291b93aa37f5ddb33a4b41c84a45cdd7d9d505a44bb19bab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>antiretroviral therapy</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Biological and medical sciences</topic><topic>Cameroon - epidemiology</topic><topic>Case-Control Studies</topic><topic>CD4 antigen</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - transmission</topic><topic>HIV-1 - pathogenicity</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infection</topic><topic>Infectious diseases</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Mortality</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Pregnancy Complications, Infectious - diagnosis</topic><topic>Pregnancy Complications, Infectious - epidemiology</topic><topic>Pregnancy Complications, Infectious - etiology</topic><topic>Prevalence</topic><topic>Prognosis</topic><topic>Proteinuria</topic><topic>Proteinuria - diagnosis</topic><topic>Proteinuria - epidemiology</topic><topic>Proteinuria - etiology</topic><topic>Survival Rate</topic><topic>Urine</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jao, Jennifer</creatorcontrib><creatorcontrib>Palmer, Dennis</creatorcontrib><creatorcontrib>Leus, Ine</creatorcontrib><creatorcontrib>Tih, Pius</creatorcontrib><creatorcontrib>Baweja, Mukta</creatorcontrib><creatorcontrib>Klotman, Mary</creatorcontrib><creatorcontrib>Sperling, Rhoda</creatorcontrib><creatorcontrib>Wyatt, Christina</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nephrology, dialysis, transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jao, Jennifer</au><au>Palmer, Dennis</au><au>Leus, Ine</au><au>Tih, Pius</au><au>Baweja, Mukta</au><au>Klotman, Mary</au><au>Sperling, Rhoda</au><au>Wyatt, Christina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon</atitle><jtitle>Nephrology, dialysis, transplantation</jtitle><addtitle>Nephrol Dial Transplant</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>26</volume><issue>9</issue><spage>3051</spage><epage>3053</epage><pages>3051-3053</pages><issn>0931-0509</issn><eissn>1460-2385</eissn><coden>NDTREA</coden><abstract>Background. Proteinuria during pregnancy has been associated with increased pregnancy complications. Furthermore, even low-grade proteinuria has been associated with increased mortality in the general population and in non-pregnant HIV-infected women.
Methods. Urine dipstick protein was measured prospectively on HIV-infected and trace protein or more and quantified by urine protein:creatinine measurement (P:C). Logistic regression modeling was used to identify factors associated with proteinuria.
Results. About 199 human immunodeficiency virus (HIV)-infected and 190 HIV-uninfected normotensive pregnant women were evaluated. The median age was 27 years in both groups and 37% presented in the third trimester. Among HIV-infected women, median CD4 cell count was 417 cells/mm3; 27% were on combination antiretroviral therapy (cART). Proteinuria was present in 39.2% of HIV-infected and 20.9% of uninfected women (P < 0.001). HIV infection was independently associated with proteinuria [adjusted odds ratio (OR) = 2.45; confidence interval (CI) = 1.56-3.85]. Among HIV-infected pregnant women, cART was protective (adjusted OR = 0.39; CI = 0.19-0.82). Results were qualitatively similar when urine P:C was evaluated as a continuous outcome variable.
Conclusions. The prevalence of low-grade proteinuria in both HIV-infected and -uninfected Cameroonian pregnant women is high. HIV-infected pregnant women are at increased risk for proteinuria, and cART appears to exert a protective effect. Further studies are needed to elucidate the causes of increased proteinuria in African pregnant women, both HIV-infected and -uninfected.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21719713</pmid><doi>10.1093/ndt/gfr310</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Age Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy antiretroviral therapy Antiretroviral Therapy, Highly Active Biological and medical sciences Cameroon - epidemiology Case-Control Studies CD4 antigen Emergency and intensive care: renal failure. Dialysis management Female Follow-Up Studies HIV Infections - complications HIV Infections - epidemiology HIV Infections - transmission HIV-1 - pathogenicity Human immunodeficiency virus Human viral diseases Humans Infection Infectious diseases Intensive care medicine Medical sciences Mortality Pregnancy Pregnancy complications Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - etiology Prevalence Prognosis Proteinuria Proteinuria - diagnosis Proteinuria - epidemiology Proteinuria - etiology Survival Rate Urine Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Young Adult |
| title | Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon |
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