Association Between SLC20A1 and Sodium-Lithium Countertransport
Background Sodium-lithium countertransport (SLC) is a premorbidity marker of essential hypertension. Evidence from linkage analysis and kinetic studies in humans have suggested that SLC20A1 variations may affect SLC activity as measured in erythrocytes and leukocytes. SLC20A1 encodes a sodium-depend...
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| Veröffentlicht in: | American journal of hypertension 2011-10, Vol.24 (10), p.1069-1072 |
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| creator | Zheng, Xiaojing Morrison, Alanna C. Turner, Stephen T. Ferrell, Robert E. |
| description | Background
Sodium-lithium countertransport (SLC) is a premorbidity marker of essential hypertension. Evidence from linkage analysis and kinetic studies in humans have suggested that SLC20A1 variations may affect SLC activity as measured in erythrocytes and leukocytes. SLC20A1 encodes a sodium-dependent phosphate cotransporter, and is widely expressed on the mammalian plasma membrane. In this study, we investigated the relationship between SLC20A1 and SLC activity.
Methods
By means of gene expression profiling, we studied the expressions of SLC20A1 in individuals with high SLC activity as compared to those with low SLC activity. In order to investigate the allelic association of SLC20A1 with SLC, we genotyped six tag single-nucleotide polymorphisms (tSNPs) in SLC20A1 in subjects from the Rochester Family Heart Study (RFHS) involving 1,815 individuals from 252 pedigrees of mixed European ancestry. The genetic association of SLC20A1 with SLC was assessed by Sequential Oligogenic Linkage Analysis Routines (SOLAR).
Results
Expression levels of SLC20A1 were higher in individuals with high SLC activity than in those with low SLC activity. Four SNPs in SLC20A1 were associated with SLC activity after adjusting for age, sex, body mass index, triglycerides, and antihypertensive drug treatment (P ≤ 0.05). The strongest evidence of association was in respect of rs4849091 (P = 0.001), and this association remained significant even after correction for multiple tests.
Conclusions
Allelic variations in SLC20A1 were associated with the levels of SLC activity, thereby supporting the hypothesis that SLC20A1 is involved in determining SLC activity.
American Journal of Hypertension advance online publication 28 July 2011; doi:10.1038/ajh.2011.130 |
| doi_str_mv | 10.1038/ajh.2011.130 |
| format | Article |
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Sodium-lithium countertransport (SLC) is a premorbidity marker of essential hypertension. Evidence from linkage analysis and kinetic studies in humans have suggested that SLC20A1 variations may affect SLC activity as measured in erythrocytes and leukocytes. SLC20A1 encodes a sodium-dependent phosphate cotransporter, and is widely expressed on the mammalian plasma membrane. In this study, we investigated the relationship between SLC20A1 and SLC activity.
Methods
By means of gene expression profiling, we studied the expressions of SLC20A1 in individuals with high SLC activity as compared to those with low SLC activity. In order to investigate the allelic association of SLC20A1 with SLC, we genotyped six tag single-nucleotide polymorphisms (tSNPs) in SLC20A1 in subjects from the Rochester Family Heart Study (RFHS) involving 1,815 individuals from 252 pedigrees of mixed European ancestry. The genetic association of SLC20A1 with SLC was assessed by Sequential Oligogenic Linkage Analysis Routines (SOLAR).
Results
Expression levels of SLC20A1 were higher in individuals with high SLC activity than in those with low SLC activity. Four SNPs in SLC20A1 were associated with SLC activity after adjusting for age, sex, body mass index, triglycerides, and antihypertensive drug treatment (P ≤ 0.05). The strongest evidence of association was in respect of rs4849091 (P = 0.001), and this association remained significant even after correction for multiple tests.
Conclusions
Allelic variations in SLC20A1 were associated with the levels of SLC activity, thereby supporting the hypothesis that SLC20A1 is involved in determining SLC activity.
American Journal of Hypertension advance online publication 28 July 2011; doi:10.1038/ajh.2011.130</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1038/ajh.2011.130</identifier><identifier>PMID: 21796222</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Basingstoke: Oxford University Press</publisher><subject>Alleles ; Antiporters - physiology ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cell physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypertension - drug therapy ; Hypertension - genetics ; Hypertension - metabolism ; Linkage Disequilibrium ; Lithium - metabolism ; Male ; Medical sciences ; Membrane and intracellular transports ; Molecular and cellular biology ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide ; Sodium - metabolism ; Sodium-Phosphate Cotransporter Proteins, Type III - genetics</subject><ispartof>American journal of hypertension, 2011-10, Vol.24 (10), p.1069-1072</ispartof><rights>American Journal of Hypertension, Ltd. © 2011 by the American Journal of Hypertension, Ltd. 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Oct 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-6a6dc98fb668f4d32289955a27ef3759fdb5723a18a314f37eacdee8432dd8403</citedby><cites>FETCH-LOGICAL-c417t-6a6dc98fb668f4d32289955a27ef3759fdb5723a18a314f37eacdee8432dd8403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24574882$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21796222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Xiaojing</creatorcontrib><creatorcontrib>Morrison, Alanna C.</creatorcontrib><creatorcontrib>Turner, Stephen T.</creatorcontrib><creatorcontrib>Ferrell, Robert E.</creatorcontrib><title>Association Between SLC20A1 and Sodium-Lithium Countertransport</title><title>American journal of hypertension</title><addtitle>Am J Hypertens</addtitle><description>Background
Sodium-lithium countertransport (SLC) is a premorbidity marker of essential hypertension. Evidence from linkage analysis and kinetic studies in humans have suggested that SLC20A1 variations may affect SLC activity as measured in erythrocytes and leukocytes. SLC20A1 encodes a sodium-dependent phosphate cotransporter, and is widely expressed on the mammalian plasma membrane. In this study, we investigated the relationship between SLC20A1 and SLC activity.
Methods
By means of gene expression profiling, we studied the expressions of SLC20A1 in individuals with high SLC activity as compared to those with low SLC activity. In order to investigate the allelic association of SLC20A1 with SLC, we genotyped six tag single-nucleotide polymorphisms (tSNPs) in SLC20A1 in subjects from the Rochester Family Heart Study (RFHS) involving 1,815 individuals from 252 pedigrees of mixed European ancestry. The genetic association of SLC20A1 with SLC was assessed by Sequential Oligogenic Linkage Analysis Routines (SOLAR).
Results
Expression levels of SLC20A1 were higher in individuals with high SLC activity than in those with low SLC activity. Four SNPs in SLC20A1 were associated with SLC activity after adjusting for age, sex, body mass index, triglycerides, and antihypertensive drug treatment (P ≤ 0.05). The strongest evidence of association was in respect of rs4849091 (P = 0.001), and this association remained significant even after correction for multiple tests.
Conclusions
Allelic variations in SLC20A1 were associated with the levels of SLC activity, thereby supporting the hypothesis that SLC20A1 is involved in determining SLC activity.
American Journal of Hypertension advance online publication 28 July 2011; doi:10.1038/ajh.2011.130</description><subject>Alleles</subject><subject>Antiporters - physiology</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cell physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - genetics</subject><subject>Hypertension - metabolism</subject><subject>Linkage Disequilibrium</subject><subject>Lithium - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane and intracellular transports</subject><subject>Molecular and cellular biology</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Sodium - metabolism</subject><subject>Sodium-Phosphate Cotransporter Proteins, Type III - genetics</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp90E1LwzAYwPEgipvTm2cpgnixM3ma5uUkc_gGAw_Tc8malHW0TU1axG9vyqYDD54eCD-eJH-EzgmeEpyIW7VZTwETMiUJPkBjIimJOUB6iMZYyDTmmJEROvF-gzGmjJFjNALCJQOAMbqbeW_zUnWlbaJ7030a00TLxRzwjESq0dHS6rKv40XZrcOM5rZvOuM6pxrfWtedoqNCVd6c7eYEvT8-vM2f48Xr08t8tohzSngXM8V0LkWxYkwUVCcAQso0VcBNkfBUFnqVckgUESohNBwZlWtjBE1Aa0FxMkHX272tsx-98V1Wlz43VaUaY3ufCQmSslQM8vKP3NjeNeFxA8LACbCAbrYod9Z7Z4qsdWWt3FdGcDZkzULWbMiahayBX-x29qva6F_80zGAqx1QPldVEfLkpd87mnIqBOy_Yfv2_yu_AdR0ihs</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Zheng, Xiaojing</creator><creator>Morrison, Alanna C.</creator><creator>Turner, Stephen T.</creator><creator>Ferrell, Robert E.</creator><general>Oxford University Press</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Association Between SLC20A1 and Sodium-Lithium Countertransport</title><author>Zheng, Xiaojing ; Morrison, Alanna C. ; Turner, Stephen T. ; Ferrell, Robert E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-6a6dc98fb668f4d32289955a27ef3759fdb5723a18a314f37eacdee8432dd8403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alleles</topic><topic>Antiporters - physiology</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cell physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - genetics</topic><topic>Hypertension - metabolism</topic><topic>Linkage Disequilibrium</topic><topic>Lithium - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane and intracellular transports</topic><topic>Molecular and cellular biology</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Sodium - metabolism</topic><topic>Sodium-Phosphate Cotransporter Proteins, Type III - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Xiaojing</creatorcontrib><creatorcontrib>Morrison, Alanna C.</creatorcontrib><creatorcontrib>Turner, Stephen T.</creatorcontrib><creatorcontrib>Ferrell, Robert E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Xiaojing</au><au>Morrison, Alanna C.</au><au>Turner, Stephen T.</au><au>Ferrell, Robert E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between SLC20A1 and Sodium-Lithium Countertransport</atitle><jtitle>American journal of hypertension</jtitle><addtitle>Am J Hypertens</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>24</volume><issue>10</issue><spage>1069</spage><epage>1072</epage><pages>1069-1072</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><coden>AJHYE6</coden><abstract>Background
Sodium-lithium countertransport (SLC) is a premorbidity marker of essential hypertension. Evidence from linkage analysis and kinetic studies in humans have suggested that SLC20A1 variations may affect SLC activity as measured in erythrocytes and leukocytes. SLC20A1 encodes a sodium-dependent phosphate cotransporter, and is widely expressed on the mammalian plasma membrane. In this study, we investigated the relationship between SLC20A1 and SLC activity.
Methods
By means of gene expression profiling, we studied the expressions of SLC20A1 in individuals with high SLC activity as compared to those with low SLC activity. In order to investigate the allelic association of SLC20A1 with SLC, we genotyped six tag single-nucleotide polymorphisms (tSNPs) in SLC20A1 in subjects from the Rochester Family Heart Study (RFHS) involving 1,815 individuals from 252 pedigrees of mixed European ancestry. The genetic association of SLC20A1 with SLC was assessed by Sequential Oligogenic Linkage Analysis Routines (SOLAR).
Results
Expression levels of SLC20A1 were higher in individuals with high SLC activity than in those with low SLC activity. Four SNPs in SLC20A1 were associated with SLC activity after adjusting for age, sex, body mass index, triglycerides, and antihypertensive drug treatment (P ≤ 0.05). The strongest evidence of association was in respect of rs4849091 (P = 0.001), and this association remained significant even after correction for multiple tests.
Conclusions
Allelic variations in SLC20A1 were associated with the levels of SLC activity, thereby supporting the hypothesis that SLC20A1 is involved in determining SLC activity.
American Journal of Hypertension advance online publication 28 July 2011; doi:10.1038/ajh.2011.130</abstract><cop>Basingstoke</cop><pub>Oxford University Press</pub><pmid>21796222</pmid><doi>10.1038/ajh.2011.130</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alleles Antiporters - physiology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell physiology Female Fundamental and applied biological sciences. Psychology Humans Hypertension - drug therapy Hypertension - genetics Hypertension - metabolism Linkage Disequilibrium Lithium - metabolism Male Medical sciences Membrane and intracellular transports Molecular and cellular biology Oligonucleotide Array Sequence Analysis Polymorphism, Single Nucleotide Sodium - metabolism Sodium-Phosphate Cotransporter Proteins, Type III - genetics |
| title | Association Between SLC20A1 and Sodium-Lithium Countertransport |
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