Specific PET Imaging of xC― Transporter Activity Using a 18F-Labeled Glutamate Derivative Reveals a Dominant Pathway in Tumor Metabolism

(18)F-labeled small molecules targeting adaptations of tumor metabolism possess the potential for early tumor detection with high sensitivity and specificity by positron emission tomography (PET) imaging. Compounds tracing deranged pathways other than glycolysis may have advantages in situations whe...

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Veröffentlicht in:	Clinical cancer research 2011-09, Vol.17 (18), p.6000-6011
Hauptverfasser:	KOGLIN, Norman, MUELLER, Andre, BERNDT, Mathias, SCHMITT-WILLICH, Heribert, TOSCHI, Luisella, STEPHENS, Andrew W, GEKELER, Volker, FRIEBE, Matthias, DINKELBORG, Ludger M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System y+ - genetics Amino Acid Transport System y+ - metabolism Animals Antineoplastic agents Biological and medical sciences Cell Line, Tumor Female Glutamates - metabolism Glutamates - pharmacokinetics Humans Medical sciences Mice Mice, Nude Multimodal Imaging Neoplasms - diagnostic imaging Neoplasms - metabolism Pharmacology. Drug treatments Positron-Emission Tomography Radiopharmaceuticals - metabolism Rats Rats, Nude Signal Transduction Tomography, X-Ray Computed Xenograft Model Antitumor Assays
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