Virus-associated Hemophagocytic Syndrome (VAHS) as an Initial Manifestation in HIV Infection
A 21-year-old man admitted for idiopathic fever and sore throat was diagnosed with virus-associated hemophagocytic syndrome (VAHS) when bone marrow aspirate showed hemophagocytosis. ELISA for HIV antibodies was negative, although HIV RNA was positive. VAHS is extremely rare as an initial manifestati...
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| Veröffentlicht in: | Nippon Jibi Inkoka Gakkai Kaiho 2011, Vol.114(8), pp.726-730 |
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| container_title | Nippon Jibi Inkoka Gakkai Kaiho |
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| creator | Nagaya, Keiko Yokoi, Hidenori Narui, Yuya Haruyama, Takuo Yoshii, Ryouta Yanai, Aya Yoshikawa, Hiroshi Ikeda, Katsuhisa |
| description | A 21-year-old man admitted for idiopathic fever and sore throat was diagnosed with virus-associated hemophagocytic syndrome (VAHS) when bone marrow aspirate showed hemophagocytosis. ELISA for HIV antibodies was negative, although HIV RNA was positive. VAHS is extremely rare as an initial manifestation in HIV infection, being reported, to our knowledge, in only 4 subjects in Japan. Hemophagocytic syndrome (HPS) features fever and hepatosplenomegaly associated with pancytopenia, hypertriglyceridemia, and hypofibrinogemia, due to hypercytokinemia. Physicians should thus be aware that primary HIV infection may involve glandular-fever-like illness and should start prompt diagnosis to contain AIDS spread. |
| doi_str_mv | 10.3950/jibiinkoka.114.726 |
| format | Article |
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ELISA for HIV antibodies was negative, although HIV RNA was positive. VAHS is extremely rare as an initial manifestation in HIV infection, being reported, to our knowledge, in only 4 subjects in Japan. Hemophagocytic syndrome (HPS) features fever and hepatosplenomegaly associated with pancytopenia, hypertriglyceridemia, and hypofibrinogemia, due to hypercytokinemia. 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ELISA for HIV antibodies was negative, although HIV RNA was positive. VAHS is extremely rare as an initial manifestation in HIV infection, being reported, to our knowledge, in only 4 subjects in Japan. Hemophagocytic syndrome (HPS) features fever and hepatosplenomegaly associated with pancytopenia, hypertriglyceridemia, and hypofibrinogemia, due to hypercytokinemia. Physicians should thus be aware that primary HIV infection may involve glandular-fever-like illness and should start prompt diagnosis to contain AIDS spread.</description><subject>HIV Infections - complications</subject><subject>HIV RNA</subject><subject>Humans</subject><subject>Lymphohistiocytosis, Hemophagocytic - etiology</subject><subject>primary HIV infection</subject><subject>VAHS (virus-associated hemophagocytic syndrome)</subject><subject>Young Adult</subject><issn>0030-6622</issn><issn>1883-0854</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1vEzEQhi0EolHpH-CAfAMOG_yxH_axqoCN1IpDIScka-Idt2537WBvDvn3OEpIJS4ea-aZV6OHkPecLaVu2Jcnv_E-PMdnWHJeLzvRviILrpSsmGrq12TBmGRV2wpxQa5y9hvGmK6ZFOwtuRBccy2ZXpDfa592uYKco_Uw40B7nOL2ER6i3c_e0vt9GFKckH5aX_f3nylkCoGugp89jPQOgneYZ5h9DNQH2q_WZejQHhrvyBsHY8arU70kv759_XnTV7c_vq9urm8rK0XbVg0M2AygrWxAK8ldq7quQdWhtdxJNtS17JS0wDo4fOtGKOwGdOhK22l5ST4ec7cp_tmVc8zks8VxhIBxl43SrFVctAdSHEmbYs4JndkmP0HaG87Mwat58WqKV1O8lqUPp_jdZsLhvPLPYgH6I_BUTDzgGYBUDI74f6Y6vSX7jNhHSAaD_Atl6pBX</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Nagaya, Keiko</creator><creator>Yokoi, Hidenori</creator><creator>Narui, Yuya</creator><creator>Haruyama, Takuo</creator><creator>Yoshii, Ryouta</creator><creator>Yanai, Aya</creator><creator>Yoshikawa, Hiroshi</creator><creator>Ikeda, Katsuhisa</creator><general>The Oto-Rhino-Laryngological Society of Japan, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Virus-associated Hemophagocytic Syndrome (VAHS) as an Initial Manifestation in HIV Infection</title><author>Nagaya, Keiko ; Yokoi, Hidenori ; Narui, Yuya ; Haruyama, Takuo ; Yoshii, Ryouta ; Yanai, Aya ; Yoshikawa, Hiroshi ; Ikeda, Katsuhisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3266-5ade5da9c35a9831f68775e87ecc1f30d443783ca07a44374528e7defef783f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>2011</creationdate><topic>HIV Infections - complications</topic><topic>HIV RNA</topic><topic>Humans</topic><topic>Lymphohistiocytosis, Hemophagocytic - etiology</topic><topic>primary HIV infection</topic><topic>VAHS (virus-associated hemophagocytic syndrome)</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagaya, Keiko</creatorcontrib><creatorcontrib>Yokoi, Hidenori</creatorcontrib><creatorcontrib>Narui, Yuya</creatorcontrib><creatorcontrib>Haruyama, Takuo</creatorcontrib><creatorcontrib>Yoshii, Ryouta</creatorcontrib><creatorcontrib>Yanai, Aya</creatorcontrib><creatorcontrib>Yoshikawa, Hiroshi</creatorcontrib><creatorcontrib>Ikeda, Katsuhisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nippon Jibi Inkoka Gakkai Kaiho</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagaya, Keiko</au><au>Yokoi, Hidenori</au><au>Narui, Yuya</au><au>Haruyama, Takuo</au><au>Yoshii, Ryouta</au><au>Yanai, Aya</au><au>Yoshikawa, Hiroshi</au><au>Ikeda, Katsuhisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Virus-associated Hemophagocytic Syndrome (VAHS) as an Initial Manifestation in HIV Infection</atitle><jtitle>Nippon Jibi Inkoka Gakkai Kaiho</jtitle><addtitle>Nippon Jibiinkoka Gakkai Kaiho</addtitle><date>2011</date><risdate>2011</risdate><volume>114</volume><issue>8</issue><spage>726</spage><epage>730</epage><pages>726-730</pages><issn>0030-6622</issn><eissn>1883-0854</eissn><abstract>A 21-year-old man admitted for idiopathic fever and sore throat was diagnosed with virus-associated hemophagocytic syndrome (VAHS) when bone marrow aspirate showed hemophagocytosis. 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| ispartof | Nippon Jibiinkoka Gakkai Kaiho, 2011, Vol.114(8), pp.726-730 |
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| language | eng ; jpn |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | HIV Infections - complications HIV RNA Humans Lymphohistiocytosis, Hemophagocytic - etiology primary HIV infection VAHS (virus-associated hemophagocytic syndrome) Young Adult |
| title | Virus-associated Hemophagocytic Syndrome (VAHS) as an Initial Manifestation in HIV Infection |
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