Progression from Normal to Reduced Left Ventricular Ejection Fraction in Patients With Concentric Left Ventricular Hypertrophy After Long-Term Follow-Up
Whether concentric left ventricular (LV) hypertrophy (LVH) is a common precursor to depressed LV ejection fraction (EF) in humans is uncertain. From 1992 through 1994, 555 patients at our institution underwent echocardiography and had LVH (posterior or septal wall thickness ≥1.3 cm or concentric LVH...
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| Veröffentlicht in: | The American journal of cardiology 2011-10, Vol.108 (7), p.997-1001 |
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| creator | Krishnamoorthy, Arun, MD Brown, Timothy, BS Ayers, Colby R., MS Gupta, Sachin, MD, MSc Rame, J. Eduardo, MD, MPhil Patel, Parag C., MD Markham, David W., MD, MSc Drazner, Mark H., MD, MSc |
| description | Whether concentric left ventricular (LV) hypertrophy (LVH) is a common precursor to depressed LV ejection fraction (EF) in humans is uncertain. From 1992 through 1994, 555 patients at our institution underwent echocardiography and had LVH (posterior or septal wall thickness ≥1.3 cm or concentric LVH noted) and normal LVEF. Of these, 220 (40%) had a follow-up assessment of LVEF by December 2008. The duration of follow-up was classified as short (≤7.5 years) or long (>7.5 years) term. The primary outcome was the development of a qualitatively depressed LVEF (mildly, moderately, or severely depressed). After a median follow-up of 7.5 years, 20% of the patients with concentric LVH developed a low LVEF. A low LVEF developed in 13% of subjects without interval myocardial infarction (MI) and 50% of subjects with interval MI during short-term follow-up (p |
| doi_str_mv | 10.1016/j.amjcard.2011.05.037 |
| format | Article |
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Eduardo, MD, MPhil ; Patel, Parag C., MD ; Markham, David W., MD, MSc ; Drazner, Mark H., MD, MSc</creator><creatorcontrib>Krishnamoorthy, Arun, MD ; Brown, Timothy, BS ; Ayers, Colby R., MS ; Gupta, Sachin, MD, MSc ; Rame, J. Eduardo, MD, MPhil ; Patel, Parag C., MD ; Markham, David W., MD, MSc ; Drazner, Mark H., MD, MSc</creatorcontrib><description>Whether concentric left ventricular (LV) hypertrophy (LVH) is a common precursor to depressed LV ejection fraction (EF) in humans is uncertain. From 1992 through 1994, 555 patients at our institution underwent echocardiography and had LVH (posterior or septal wall thickness ≥1.3 cm or concentric LVH noted) and normal LVEF. Of these, 220 (40%) had a follow-up assessment of LVEF by December 2008. The duration of follow-up was classified as short (≤7.5 years) or long (>7.5 years) term. The primary outcome was the development of a qualitatively depressed LVEF (mildly, moderately, or severely depressed). After a median follow-up of 7.5 years, 20% of the patients with concentric LVH developed a low LVEF. A low LVEF developed in 13% of subjects without interval myocardial infarction (MI) and 50% of subjects with interval MI during short-term follow-up (p <0.005). A low LVEF developed in 20% of subjects without interval MI and 44% of subjects with interval MI during long-term follow-up (p = 0.01). Of the subjects who developed a reduced LVEF, the relative wall thickness (median 0.5, 25th to 75th percentile 0.4 to 0.6) at follow-up was consistent with a concentric, rather than eccentric, phenotype. In conclusion, in patients with concentric LVH, the transition from a normal LVEF to a low LVEF was relatively infrequent (20%) after long-term follow-up in the absence of interval MI and usually did not result in a change in the LV geometry from a concentric to an eccentric phenotype.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2011.05.037</identifier><identifier>PMID: 21798496</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cardiology ; Cardiology. 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Eduardo, MD, MPhil</creatorcontrib><creatorcontrib>Patel, Parag C., MD</creatorcontrib><creatorcontrib>Markham, David W., MD, MSc</creatorcontrib><creatorcontrib>Drazner, Mark H., MD, MSc</creatorcontrib><title>Progression from Normal to Reduced Left Ventricular Ejection Fraction in Patients With Concentric Left Ventricular Hypertrophy After Long-Term Follow-Up</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Whether concentric left ventricular (LV) hypertrophy (LVH) is a common precursor to depressed LV ejection fraction (EF) in humans is uncertain. From 1992 through 1994, 555 patients at our institution underwent echocardiography and had LVH (posterior or septal wall thickness ≥1.3 cm or concentric LVH noted) and normal LVEF. Of these, 220 (40%) had a follow-up assessment of LVEF by December 2008. The duration of follow-up was classified as short (≤7.5 years) or long (>7.5 years) term. The primary outcome was the development of a qualitatively depressed LVEF (mildly, moderately, or severely depressed). After a median follow-up of 7.5 years, 20% of the patients with concentric LVH developed a low LVEF. A low LVEF developed in 13% of subjects without interval myocardial infarction (MI) and 50% of subjects with interval MI during short-term follow-up (p <0.005). A low LVEF developed in 20% of subjects without interval MI and 44% of subjects with interval MI during long-term follow-up (p = 0.01). Of the subjects who developed a reduced LVEF, the relative wall thickness (median 0.5, 25th to 75th percentile 0.4 to 0.6) at follow-up was consistent with a concentric, rather than eccentric, phenotype. 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Eduardo, MD, MPhil</au><au>Patel, Parag C., MD</au><au>Markham, David W., MD, MSc</au><au>Drazner, Mark H., MD, MSc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Progression from Normal to Reduced Left Ventricular Ejection Fraction in Patients With Concentric Left Ventricular Hypertrophy After Long-Term Follow-Up</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>108</volume><issue>7</issue><spage>997</spage><epage>1001</epage><pages>997-1001</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Whether concentric left ventricular (LV) hypertrophy (LVH) is a common precursor to depressed LV ejection fraction (EF) in humans is uncertain. From 1992 through 1994, 555 patients at our institution underwent echocardiography and had LVH (posterior or septal wall thickness ≥1.3 cm or concentric LVH noted) and normal LVEF. Of these, 220 (40%) had a follow-up assessment of LVEF by December 2008. The duration of follow-up was classified as short (≤7.5 years) or long (>7.5 years) term. The primary outcome was the development of a qualitatively depressed LVEF (mildly, moderately, or severely depressed). After a median follow-up of 7.5 years, 20% of the patients with concentric LVH developed a low LVEF. A low LVEF developed in 13% of subjects without interval myocardial infarction (MI) and 50% of subjects with interval MI during short-term follow-up (p <0.005). A low LVEF developed in 20% of subjects without interval MI and 44% of subjects with interval MI during long-term follow-up (p = 0.01). Of the subjects who developed a reduced LVEF, the relative wall thickness (median 0.5, 25th to 75th percentile 0.4 to 0.6) at follow-up was consistent with a concentric, rather than eccentric, phenotype. In conclusion, in patients with concentric LVH, the transition from a normal LVEF to a low LVEF was relatively infrequent (20%) after long-term follow-up in the absence of interval MI and usually did not result in a change in the LV geometry from a concentric to an eccentric phenotype.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21798496</pmid><doi>10.1016/j.amjcard.2011.05.037</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular disease Cardiovascular system Disease Progression Echocardiography Female Follow-Up Studies Genotype & phenotype Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - physiopathology Investigative techniques of hemodynamics Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Prognosis Retrospective Studies Stroke Volume - physiology Time Factors Ventricular Function, Left - physiology |
| title | Progression from Normal to Reduced Left Ventricular Ejection Fraction in Patients With Concentric Left Ventricular Hypertrophy After Long-Term Follow-Up |
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