Polycystic ovarian morphology in adolescents with regular menstrual cycles is associated with elevated anti-Müllerian hormone
BACKGROUND The significance of polycystic ovarian morphology (PCOM) during adolescence is not clear. The aim of this study was to determine the relationship between PCOM and anti-Müllerian hormone (AMH), inhibin B, testosterone and insulin levels in healthy girls during the second decade of life. We...
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| Veröffentlicht in: | Human reproduction (Oxford) 2011-10, Vol.26 (10), p.2861-2868 |
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| creator | Villarroel, C. Merino, P.M. López, P. Eyzaguirre, F.C. Van Velzen, A. Iñiguez, G. Codner, E. |
| description | BACKGROUND
The significance of polycystic ovarian morphology (PCOM) during adolescence is not clear. The aim of this study was to determine the relationship between PCOM and anti-Müllerian hormone (AMH), inhibin B, testosterone and insulin levels in healthy girls during the second decade of life. We also determined whether AMH could be used as a surrogate marker of PCOM during adolescence.
METHODS
Seventy-four non-obese adolescents (age range: 13.5−19.75 years old) with regular menstrual cycles participated in this study. Transabdominal ultrasound and blood samples were obtained during the follicular phase.
RESULTS
PCOM was present in 33.8% of the subjects. Girls with PCOM had higher AMH levels than girls without PCOM (72.5 ± 6.1 versus 33.4 ± 2.6 pmol/l; P < 0.0001) and lower FSH levels (5.4 ± 0.3 versus 6.2 ± 0.2 mUI/ml; P < 0.036). Similar levels of inhibin B, androgens and LH were observed in girls with and without PCOM. PCOM prevalence and AMH levels were not associated with age (P= 0.745 and 0.2, respectively) or BMI-SDS (P= 0.951 and 0.096, respectively). AMH levels positively correlated with the of 2–5 mm follicle number. AMH levels ≥60.15 pmol/l had a sensitivity and specificity of 64.0 and 89.8%, respectively, to diagnose PCOM (area under the curve = 0.873).
CONCLUSIONS
These data confirm that PCOM in healthy non-hyperandrogenic girls with regular menstrual cycles is prevalent and is not associated with hyperandrogenism. The elevated AMH and lower FSH levels observed in healthy girls with regular menses and PCOM suggest that this ovarian pattern is secondary to a larger number of 2–5 mm follicles. An elevated AMH level is suggestive of the presence of PCOM during adolescence. |
| doi_str_mv | 10.1093/humrep/der223 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_890675938</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/humrep/der223</oup_id><sourcerecordid>890675938</sourcerecordid><originalsourceid>FETCH-LOGICAL-c324t-c2eeb263e270dac2239a2f9b1d9a57017fc7c0e661fd42cf8c6eaac1f878c6063</originalsourceid><addsrcrecordid>eNqF0DFv1TAQB3CrArWPtmNX5AXBEmo7iZ2MqKIFqRUMdI7uXS59Rk4c7KQoSz9ZN74YpnnQkenupJ_udH_GzqR4L0Wdn-_mPtB43lJQKj9gG1lokam8FC_YRihdZVJqecRexfhdiNRW-pAdKWmqwuR6wx6-erfgEieL3N9DsDDw3odx552_W7gdOLTeUUQapsh_2mnHA93NDgLvaYhTmMFxXDARbiOHGD1amKhdLTm6f5pgmGx28-vROXq6sfOh9wOdsJcduEin-3rMbi8_frv4lF1_ufp88eE6w1wVU4aKaKt0TsqIFjB9WoPq6q1sayiNkKZDg4K0ll1bKOwq1ASAsqtMaoXOj9nbde8Y_I-Z4tT0Nv3kHAzk59hUtdCmrPMqyWyVGHyMgbpmDLaHsDRSNH8Sb9bEmzXx5F_vN8_bntp_-m_ECbzZA4gIrgswoI3PrigLUZYmuXer8_P4n5u_AXj6ni8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>890675938</pqid></control><display><type>article</type><title>Polycystic ovarian morphology in adolescents with regular menstrual cycles is associated with elevated anti-Müllerian hormone</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Villarroel, C. ; Merino, P.M. ; López, P. ; Eyzaguirre, F.C. ; Van Velzen, A. ; Iñiguez, G. ; Codner, E.</creator><creatorcontrib>Villarroel, C. ; Merino, P.M. ; López, P. ; Eyzaguirre, F.C. ; Van Velzen, A. ; Iñiguez, G. ; Codner, E.</creatorcontrib><description>BACKGROUND
The significance of polycystic ovarian morphology (PCOM) during adolescence is not clear. The aim of this study was to determine the relationship between PCOM and anti-Müllerian hormone (AMH), inhibin B, testosterone and insulin levels in healthy girls during the second decade of life. We also determined whether AMH could be used as a surrogate marker of PCOM during adolescence.
METHODS
Seventy-four non-obese adolescents (age range: 13.5−19.75 years old) with regular menstrual cycles participated in this study. Transabdominal ultrasound and blood samples were obtained during the follicular phase.
RESULTS
PCOM was present in 33.8% of the subjects. Girls with PCOM had higher AMH levels than girls without PCOM (72.5 ± 6.1 versus 33.4 ± 2.6 pmol/l; P < 0.0001) and lower FSH levels (5.4 ± 0.3 versus 6.2 ± 0.2 mUI/ml; P < 0.036). Similar levels of inhibin B, androgens and LH were observed in girls with and without PCOM. PCOM prevalence and AMH levels were not associated with age (P= 0.745 and 0.2, respectively) or BMI-SDS (P= 0.951 and 0.096, respectively). AMH levels positively correlated with the of 2–5 mm follicle number. AMH levels ≥60.15 pmol/l had a sensitivity and specificity of 64.0 and 89.8%, respectively, to diagnose PCOM (area under the curve = 0.873).
CONCLUSIONS
These data confirm that PCOM in healthy non-hyperandrogenic girls with regular menstrual cycles is prevalent and is not associated with hyperandrogenism. The elevated AMH and lower FSH levels observed in healthy girls with regular menses and PCOM suggest that this ovarian pattern is secondary to a larger number of 2–5 mm follicles. An elevated AMH level is suggestive of the presence of PCOM during adolescence.</description><identifier>ISSN: 0268-1161</identifier><identifier>EISSN: 1460-2350</identifier><identifier>DOI: 10.1093/humrep/der223</identifier><identifier>PMID: 21784736</identifier><identifier>CODEN: HUREEE</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Anti-Mullerian Hormone - blood ; Biological and medical sciences ; Female ; Gene Expression Regulation ; Gynecology. Andrology. Obstetrics ; Humans ; Hyperandrogenism - diagnosis ; Inhibins - blood ; Insulin - blood ; Medical sciences ; Menstrual Cycle - physiology ; Ovary - diagnostic imaging ; Polycystic Ovary Syndrome - pathology ; ROC Curve ; Testosterone - blood ; Ultrasonography</subject><ispartof>Human reproduction (Oxford), 2011-10, Vol.26 (10), p.2861-2868</ispartof><rights>The Author 2011. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-c2eeb263e270dac2239a2f9b1d9a57017fc7c0e661fd42cf8c6eaac1f878c6063</citedby><cites>FETCH-LOGICAL-c324t-c2eeb263e270dac2239a2f9b1d9a57017fc7c0e661fd42cf8c6eaac1f878c6063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1581,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24540557$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21784736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Villarroel, C.</creatorcontrib><creatorcontrib>Merino, P.M.</creatorcontrib><creatorcontrib>López, P.</creatorcontrib><creatorcontrib>Eyzaguirre, F.C.</creatorcontrib><creatorcontrib>Van Velzen, A.</creatorcontrib><creatorcontrib>Iñiguez, G.</creatorcontrib><creatorcontrib>Codner, E.</creatorcontrib><title>Polycystic ovarian morphology in adolescents with regular menstrual cycles is associated with elevated anti-Müllerian hormone</title><title>Human reproduction (Oxford)</title><addtitle>Hum Reprod</addtitle><description>BACKGROUND
The significance of polycystic ovarian morphology (PCOM) during adolescence is not clear. The aim of this study was to determine the relationship between PCOM and anti-Müllerian hormone (AMH), inhibin B, testosterone and insulin levels in healthy girls during the second decade of life. We also determined whether AMH could be used as a surrogate marker of PCOM during adolescence.
METHODS
Seventy-four non-obese adolescents (age range: 13.5−19.75 years old) with regular menstrual cycles participated in this study. Transabdominal ultrasound and blood samples were obtained during the follicular phase.
RESULTS
PCOM was present in 33.8% of the subjects. Girls with PCOM had higher AMH levels than girls without PCOM (72.5 ± 6.1 versus 33.4 ± 2.6 pmol/l; P < 0.0001) and lower FSH levels (5.4 ± 0.3 versus 6.2 ± 0.2 mUI/ml; P < 0.036). Similar levels of inhibin B, androgens and LH were observed in girls with and without PCOM. PCOM prevalence and AMH levels were not associated with age (P= 0.745 and 0.2, respectively) or BMI-SDS (P= 0.951 and 0.096, respectively). AMH levels positively correlated with the of 2–5 mm follicle number. AMH levels ≥60.15 pmol/l had a sensitivity and specificity of 64.0 and 89.8%, respectively, to diagnose PCOM (area under the curve = 0.873).
CONCLUSIONS
These data confirm that PCOM in healthy non-hyperandrogenic girls with regular menstrual cycles is prevalent and is not associated with hyperandrogenism. The elevated AMH and lower FSH levels observed in healthy girls with regular menses and PCOM suggest that this ovarian pattern is secondary to a larger number of 2–5 mm follicles. An elevated AMH level is suggestive of the presence of PCOM during adolescence.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Mullerian Hormone - blood</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Gene Expression Regulation</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hyperandrogenism - diagnosis</subject><subject>Inhibins - blood</subject><subject>Insulin - blood</subject><subject>Medical sciences</subject><subject>Menstrual Cycle - physiology</subject><subject>Ovary - diagnostic imaging</subject><subject>Polycystic Ovary Syndrome - pathology</subject><subject>ROC Curve</subject><subject>Testosterone - blood</subject><subject>Ultrasonography</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0DFv1TAQB3CrArWPtmNX5AXBEmo7iZ2MqKIFqRUMdI7uXS59Rk4c7KQoSz9ZN74YpnnQkenupJ_udH_GzqR4L0Wdn-_mPtB43lJQKj9gG1lokam8FC_YRihdZVJqecRexfhdiNRW-pAdKWmqwuR6wx6-erfgEieL3N9DsDDw3odx552_W7gdOLTeUUQapsh_2mnHA93NDgLvaYhTmMFxXDARbiOHGD1amKhdLTm6f5pgmGx28-vROXq6sfOh9wOdsJcduEin-3rMbi8_frv4lF1_ufp88eE6w1wVU4aKaKt0TsqIFjB9WoPq6q1sayiNkKZDg4K0ll1bKOwq1ASAsqtMaoXOj9nbde8Y_I-Z4tT0Nv3kHAzk59hUtdCmrPMqyWyVGHyMgbpmDLaHsDRSNH8Sb9bEmzXx5F_vN8_bntp_-m_ECbzZA4gIrgswoI3PrigLUZYmuXer8_P4n5u_AXj6ni8</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Villarroel, C.</creator><creator>Merino, P.M.</creator><creator>López, P.</creator><creator>Eyzaguirre, F.C.</creator><creator>Van Velzen, A.</creator><creator>Iñiguez, G.</creator><creator>Codner, E.</creator><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Polycystic ovarian morphology in adolescents with regular menstrual cycles is associated with elevated anti-Müllerian hormone</title><author>Villarroel, C. ; Merino, P.M. ; López, P. ; Eyzaguirre, F.C. ; Van Velzen, A. ; Iñiguez, G. ; Codner, E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-c2eeb263e270dac2239a2f9b1d9a57017fc7c0e661fd42cf8c6eaac1f878c6063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Mullerian Hormone - blood</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Gene Expression Regulation</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hyperandrogenism - diagnosis</topic><topic>Inhibins - blood</topic><topic>Insulin - blood</topic><topic>Medical sciences</topic><topic>Menstrual Cycle - physiology</topic><topic>Ovary - diagnostic imaging</topic><topic>Polycystic Ovary Syndrome - pathology</topic><topic>ROC Curve</topic><topic>Testosterone - blood</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Villarroel, C.</creatorcontrib><creatorcontrib>Merino, P.M.</creatorcontrib><creatorcontrib>López, P.</creatorcontrib><creatorcontrib>Eyzaguirre, F.C.</creatorcontrib><creatorcontrib>Van Velzen, A.</creatorcontrib><creatorcontrib>Iñiguez, G.</creatorcontrib><creatorcontrib>Codner, E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villarroel, C.</au><au>Merino, P.M.</au><au>López, P.</au><au>Eyzaguirre, F.C.</au><au>Van Velzen, A.</au><au>Iñiguez, G.</au><au>Codner, E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polycystic ovarian morphology in adolescents with regular menstrual cycles is associated with elevated anti-Müllerian hormone</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>26</volume><issue>10</issue><spage>2861</spage><epage>2868</epage><pages>2861-2868</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><coden>HUREEE</coden><abstract>BACKGROUND
The significance of polycystic ovarian morphology (PCOM) during adolescence is not clear. The aim of this study was to determine the relationship between PCOM and anti-Müllerian hormone (AMH), inhibin B, testosterone and insulin levels in healthy girls during the second decade of life. We also determined whether AMH could be used as a surrogate marker of PCOM during adolescence.
METHODS
Seventy-four non-obese adolescents (age range: 13.5−19.75 years old) with regular menstrual cycles participated in this study. Transabdominal ultrasound and blood samples were obtained during the follicular phase.
RESULTS
PCOM was present in 33.8% of the subjects. Girls with PCOM had higher AMH levels than girls without PCOM (72.5 ± 6.1 versus 33.4 ± 2.6 pmol/l; P < 0.0001) and lower FSH levels (5.4 ± 0.3 versus 6.2 ± 0.2 mUI/ml; P < 0.036). Similar levels of inhibin B, androgens and LH were observed in girls with and without PCOM. PCOM prevalence and AMH levels were not associated with age (P= 0.745 and 0.2, respectively) or BMI-SDS (P= 0.951 and 0.096, respectively). AMH levels positively correlated with the of 2–5 mm follicle number. AMH levels ≥60.15 pmol/l had a sensitivity and specificity of 64.0 and 89.8%, respectively, to diagnose PCOM (area under the curve = 0.873).
CONCLUSIONS
These data confirm that PCOM in healthy non-hyperandrogenic girls with regular menstrual cycles is prevalent and is not associated with hyperandrogenism. The elevated AMH and lower FSH levels observed in healthy girls with regular menses and PCOM suggest that this ovarian pattern is secondary to a larger number of 2–5 mm follicles. An elevated AMH level is suggestive of the presence of PCOM during adolescence.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>21784736</pmid><doi>10.1093/humrep/der223</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Human reproduction (Oxford), 2011-10, Vol.26 (10), p.2861-2868 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Anti-Mullerian Hormone - blood Biological and medical sciences Female Gene Expression Regulation Gynecology. Andrology. Obstetrics Humans Hyperandrogenism - diagnosis Inhibins - blood Insulin - blood Medical sciences Menstrual Cycle - physiology Ovary - diagnostic imaging Polycystic Ovary Syndrome - pathology ROC Curve Testosterone - blood Ultrasonography |
| title | Polycystic ovarian morphology in adolescents with regular menstrual cycles is associated with elevated anti-Müllerian hormone |
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