Cytoreductive surgery and HIPEC in peritoneal recurrent ovarian cancer: experience and lessons learned
Purpose Peritoneal recurrence of ovarian cancer is frequent after primary surgery and chemotherapy and has poor long-term survival. De novo cytoreductive surgery is crucial with the potential to improve prognosis, especially when combined with hyperthermic intraperitoneal chemotherapy (HIPEC). Metho...
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| Veröffentlicht in: | Langenbeck's archives of surgery 2011-10, Vol.396 (7), p.1077-1081 |
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| creator | Königsrainer, Ingmar Beckert, Stefan Becker, Sven Zieker, Derek Fehm, Tanja Grischke, Eva-Maria Lauk, Olivia Glatzle, Jörg Brücher, Björn Wallwiener, Diethelm Königsrainer, Alfred |
| description | Purpose
Peritoneal recurrence of ovarian cancer is frequent after primary surgery and chemotherapy and has poor long-term survival. De novo cytoreductive surgery is crucial with the potential to improve prognosis, especially when combined with hyperthermic intraperitoneal chemotherapy (HIPEC).
Methods
The sampled data of 40 consecutive patients were retrospectively analyzed. Thirty-one patients were treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy.
Results
No patient was lost in the perioperative period, and the combined procedure was performed with acceptable morbidity. Colon-preserving cytoreductive surgery was associated with reduced morbidity.
Conclusions
Patients suffering from peritoneal recurrence of ovarian cancer should be considered for radical reoperation with HIPEC in a center with expertise in multimodal therapeutic options. Organ-preserving cytoreductive surgery allows complete cytoreduction with the goal of decreasing morbidity. |
| doi_str_mv | 10.1007/s00423-011-0835-2 |
| format | Article |
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Peritoneal recurrence of ovarian cancer is frequent after primary surgery and chemotherapy and has poor long-term survival. De novo cytoreductive surgery is crucial with the potential to improve prognosis, especially when combined with hyperthermic intraperitoneal chemotherapy (HIPEC).
Methods
The sampled data of 40 consecutive patients were retrospectively analyzed. Thirty-one patients were treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy.
Results
No patient was lost in the perioperative period, and the combined procedure was performed with acceptable morbidity. Colon-preserving cytoreductive surgery was associated with reduced morbidity.
Conclusions
Patients suffering from peritoneal recurrence of ovarian cancer should be considered for radical reoperation with HIPEC in a center with expertise in multimodal therapeutic options. Organ-preserving cytoreductive surgery allows complete cytoreduction with the goal of decreasing morbidity.</description><identifier>ISSN: 1435-2443</identifier><identifier>EISSN: 1435-2451</identifier><identifier>DOI: 10.1007/s00423-011-0835-2</identifier><identifier>PMID: 21842290</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adult ; Aged ; Antineoplastic Agents - administration & dosage ; Cardiac Surgery ; Cohort Studies ; Combined Modality Therapy ; Female ; General Surgery ; Humans ; Hyperthermia, Induced - methods ; Infusions, Parenteral ; Kaplan-Meier Estimate ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Invasiveness - pathology ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - therapy ; Neoplasm Staging ; Original Article ; Ovarian Neoplasms - mortality ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - therapy ; Ovariectomy - methods ; Peritoneal Neoplasms - mortality ; Peritoneal Neoplasms - secondary ; Peritoneal Neoplasms - therapy ; Prognosis ; Retrospective Studies ; Risk Assessment ; Statistics, Nonparametric ; Survival Analysis ; Thoracic Surgery ; Traumatic Surgery ; Treatment Outcome ; Vascular Surgery</subject><ispartof>Langenbeck's archives of surgery, 2011-10, Vol.396 (7), p.1077-1081</ispartof><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-1bee310b8b8feddd1941049700c672fddf5f88fc08d37280be6b0161c7fc0c6f3</citedby><cites>FETCH-LOGICAL-c343t-1bee310b8b8feddd1941049700c672fddf5f88fc08d37280be6b0161c7fc0c6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00423-011-0835-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00423-011-0835-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21842290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Königsrainer, Ingmar</creatorcontrib><creatorcontrib>Beckert, Stefan</creatorcontrib><creatorcontrib>Becker, Sven</creatorcontrib><creatorcontrib>Zieker, Derek</creatorcontrib><creatorcontrib>Fehm, Tanja</creatorcontrib><creatorcontrib>Grischke, Eva-Maria</creatorcontrib><creatorcontrib>Lauk, Olivia</creatorcontrib><creatorcontrib>Glatzle, Jörg</creatorcontrib><creatorcontrib>Brücher, Björn</creatorcontrib><creatorcontrib>Wallwiener, Diethelm</creatorcontrib><creatorcontrib>Königsrainer, Alfred</creatorcontrib><title>Cytoreductive surgery and HIPEC in peritoneal recurrent ovarian cancer: experience and lessons learned</title><title>Langenbeck's archives of surgery</title><addtitle>Langenbecks Arch Surg</addtitle><addtitle>Langenbecks Arch Surg</addtitle><description>Purpose
Peritoneal recurrence of ovarian cancer is frequent after primary surgery and chemotherapy and has poor long-term survival. De novo cytoreductive surgery is crucial with the potential to improve prognosis, especially when combined with hyperthermic intraperitoneal chemotherapy (HIPEC).
Methods
The sampled data of 40 consecutive patients were retrospectively analyzed. Thirty-one patients were treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy.
Results
No patient was lost in the perioperative period, and the combined procedure was performed with acceptable morbidity. Colon-preserving cytoreductive surgery was associated with reduced morbidity.
Conclusions
Patients suffering from peritoneal recurrence of ovarian cancer should be considered for radical reoperation with HIPEC in a center with expertise in multimodal therapeutic options. Organ-preserving cytoreductive surgery allows complete cytoreduction with the goal of decreasing morbidity.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Cardiac Surgery</subject><subject>Cohort Studies</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>Infusions, Parenteral</subject><subject>Kaplan-Meier Estimate</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - therapy</subject><subject>Neoplasm Staging</subject><subject>Original Article</subject><subject>Ovarian Neoplasms - mortality</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - therapy</subject><subject>Ovariectomy - methods</subject><subject>Peritoneal Neoplasms - mortality</subject><subject>Peritoneal Neoplasms - secondary</subject><subject>Peritoneal Neoplasms - therapy</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Statistics, Nonparametric</subject><subject>Survival Analysis</subject><subject>Thoracic Surgery</subject><subject>Traumatic Surgery</subject><subject>Treatment Outcome</subject><subject>Vascular Surgery</subject><issn>1435-2443</issn><issn>1435-2451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PxCAQhonR-P0DvBhunqozlG2pN7PxKzHRg54JhcHUdOkKrXH_vayrHj3NAM_7JjyMnSCcI0B9kQCkKAtALECVs0JssX2U60XOcPtvl-UeO0jpDQCqupG7bE-gkkI0sM_8fDUOkdxkx-6DeJriK8UVN8Hxu_un6znvAl9S7MYhkOl5JDvFSGHkw4eJnQncmmApXnL6XGOUD9_hnlIaQsrTxEDuiO140yc6_pmH7OXm-nl-Vzw83t7Prx4KW8pyLLAlKhFa1SpPzjlsJIJsagBb1cI752deKW9BubIWClqqWsAKbZ3vbOXLQ3a26V3G4X2iNOpFlyz1vQk0TEmrJitAhFkmcUPaOKQUyetl7BYmrjSCXtvVG7s629Vru1rkzOlP-9QuyP0lfnVmQGyAlJ9CNqnfhimG_ON_Wr8AEXOGYw</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Königsrainer, Ingmar</creator><creator>Beckert, Stefan</creator><creator>Becker, Sven</creator><creator>Zieker, Derek</creator><creator>Fehm, Tanja</creator><creator>Grischke, Eva-Maria</creator><creator>Lauk, Olivia</creator><creator>Glatzle, Jörg</creator><creator>Brücher, Björn</creator><creator>Wallwiener, Diethelm</creator><creator>Königsrainer, Alfred</creator><general>Springer-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Cytoreductive surgery and HIPEC in peritoneal recurrent ovarian cancer: experience and lessons learned</title><author>Königsrainer, Ingmar ; Beckert, Stefan ; Becker, Sven ; Zieker, Derek ; Fehm, Tanja ; Grischke, Eva-Maria ; Lauk, Olivia ; Glatzle, Jörg ; Brücher, Björn ; Wallwiener, Diethelm ; Königsrainer, Alfred</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-1bee310b8b8feddd1941049700c672fddf5f88fc08d37280be6b0161c7fc0c6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Cardiac Surgery</topic><topic>Cohort Studies</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Hyperthermia, Induced - methods</topic><topic>Infusions, Parenteral</topic><topic>Kaplan-Meier Estimate</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - therapy</topic><topic>Neoplasm Staging</topic><topic>Original Article</topic><topic>Ovarian Neoplasms - mortality</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - therapy</topic><topic>Ovariectomy - methods</topic><topic>Peritoneal Neoplasms - mortality</topic><topic>Peritoneal Neoplasms - secondary</topic><topic>Peritoneal Neoplasms - therapy</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Statistics, Nonparametric</topic><topic>Survival Analysis</topic><topic>Thoracic Surgery</topic><topic>Traumatic Surgery</topic><topic>Treatment Outcome</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Königsrainer, Ingmar</creatorcontrib><creatorcontrib>Beckert, Stefan</creatorcontrib><creatorcontrib>Becker, Sven</creatorcontrib><creatorcontrib>Zieker, Derek</creatorcontrib><creatorcontrib>Fehm, Tanja</creatorcontrib><creatorcontrib>Grischke, Eva-Maria</creatorcontrib><creatorcontrib>Lauk, Olivia</creatorcontrib><creatorcontrib>Glatzle, Jörg</creatorcontrib><creatorcontrib>Brücher, Björn</creatorcontrib><creatorcontrib>Wallwiener, Diethelm</creatorcontrib><creatorcontrib>Königsrainer, Alfred</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langenbeck's archives of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Königsrainer, Ingmar</au><au>Beckert, Stefan</au><au>Becker, Sven</au><au>Zieker, Derek</au><au>Fehm, Tanja</au><au>Grischke, Eva-Maria</au><au>Lauk, Olivia</au><au>Glatzle, Jörg</au><au>Brücher, Björn</au><au>Wallwiener, Diethelm</au><au>Königsrainer, Alfred</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytoreductive surgery and HIPEC in peritoneal recurrent ovarian cancer: experience and lessons learned</atitle><jtitle>Langenbeck's archives of surgery</jtitle><stitle>Langenbecks Arch Surg</stitle><addtitle>Langenbecks Arch Surg</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>396</volume><issue>7</issue><spage>1077</spage><epage>1081</epage><pages>1077-1081</pages><issn>1435-2443</issn><eissn>1435-2451</eissn><abstract>Purpose
Peritoneal recurrence of ovarian cancer is frequent after primary surgery and chemotherapy and has poor long-term survival. De novo cytoreductive surgery is crucial with the potential to improve prognosis, especially when combined with hyperthermic intraperitoneal chemotherapy (HIPEC).
Methods
The sampled data of 40 consecutive patients were retrospectively analyzed. Thirty-one patients were treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy.
Results
No patient was lost in the perioperative period, and the combined procedure was performed with acceptable morbidity. Colon-preserving cytoreductive surgery was associated with reduced morbidity.
Conclusions
Patients suffering from peritoneal recurrence of ovarian cancer should be considered for radical reoperation with HIPEC in a center with expertise in multimodal therapeutic options. Organ-preserving cytoreductive surgery allows complete cytoreduction with the goal of decreasing morbidity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21842290</pmid><doi>10.1007/s00423-011-0835-2</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1435-2443 |
| ispartof | Langenbeck's archives of surgery, 2011-10, Vol.396 (7), p.1077-1081 |
| issn | 1435-2443 1435-2451 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_890671105 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Abdominal Surgery Adult Aged Antineoplastic Agents - administration & dosage Cardiac Surgery Cohort Studies Combined Modality Therapy Female General Surgery Humans Hyperthermia, Induced - methods Infusions, Parenteral Kaplan-Meier Estimate Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness - pathology Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - therapy Neoplasm Staging Original Article Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Ovariectomy - methods Peritoneal Neoplasms - mortality Peritoneal Neoplasms - secondary Peritoneal Neoplasms - therapy Prognosis Retrospective Studies Risk Assessment Statistics, Nonparametric Survival Analysis Thoracic Surgery Traumatic Surgery Treatment Outcome Vascular Surgery |
| title | Cytoreductive surgery and HIPEC in peritoneal recurrent ovarian cancer: experience and lessons learned |
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