Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice

The goal of the present study was to elucidate the mechanisms of immunoregulation by which dietary punicic acid (PUA) prevents or ameliorates experimental inflammatory bowel disease (IBD). The expression of PPARγ and δ, their responsive genes and pro-inflammatory cytokines was assayed in the colonic...

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Veröffentlicht in:	British journal of nutrition 2011-09, Vol.106 (6), p.878-886
Hauptverfasser:	Bassaganya-Riera, Josep, DiGuardo, Margaret, Climent, Montse, Vives, Cristina, Carbo, Adria, Jouni, Zeina E., Einerhand, Alexandra W. C., O'Shea, Marianne, Hontecillas, Raquel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Feed Animals anti-inflammatory activity Anti-Inflammatory Agents - pharmacology Biological and medical sciences colitis dextran Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gene Deletion genes immunomodulation Inflammation Inflammatory Bowel Diseases - drug therapy Interleukin-10 - genetics Intestinal Mucosa - microbiology Intestines - metabolism Linolenic Acids - pharmacology macrophages Mice Mice, Inbred C57BL Mice, Transgenic mucosa Nutritional Immunology PPAR delta - metabolism PPAR gamma - metabolism protective effect sodium sulfate T-Lymphocytes - cytology T-Lymphocytes, Regulatory - cytology tumor necrosis factor-alpha Vertebrates: anatomy and physiology, studies on body, several organs or systems
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