Bacteremia caused by Brevundimonas species at a tertiary care hospital in Taiwan, 2000–2010
We investigated clinical and microbiological characteristics of 30 patients with Brevundimonas bacteremia treated at a tertiary care hospital in Taiwan during 2000–2010. All the 30 bacteria isolates were confirmed to the species level by 16S rRNA sequencing analysis. Minimum inhibitory concentration...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2011-10, Vol.30 (10), p.1185-1191 |
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| creator | Lee, M. R. Huang, Y. T. Liao, C. H. Chuang, T. Y. Lin, C. K. Lee, S. W. Lai, C. C. Yu, C. J. Hsueh, P. R. |
| description | We investigated clinical and microbiological characteristics of 30 patients with
Brevundimonas
bacteremia treated at a tertiary care hospital in Taiwan during 2000–2010. All the 30 bacteria isolates were confirmed to the species level by 16S rRNA sequencing analysis. Minimum inhibitory concentrations (MICs) of 11 antimicrobial agents against these isolates were determined by the agar dilution method. Seventeen (57%) patients had underlying malignancy, 12 (40%) had undergone central catheter placement, and 13 (43%) had received chemotherapy within the previous three months. Eight (27%) patients had community-acquired bacteremia and the remaining 22 patients (73%) had healthcare-associated bacteremia. The overall 14-day and 30-day mortality rates were 13% and 17%, respectively. Among the 30 isolates,
B. vesicularis
constituted most commonly (
n
= 22, 63%), followed by
B. nasdae
(
n
= 5) and
B. diminuta
(
n
= 3). All isolates were susceptible to piperacillin-tazobactam and amikacin, while all were resistant to ciprofloxacin and colistin. Tigecycline (MICs at which 90% of isolates are inhibited [MIC
90
] was 0.12 mg/L) and doripenem (MIC
90
of 1 mg/L) both possessed good in vitro activities. In conclusions,
Brevundimonas
should be considered a pathogen that can cause bacteremia in immunocompromised hosts. Piperacillin-tazobactam, amikacin, doripenem, and tigecycline exhibit good in vitro activities against these ciprofloxacin- and colistin-resistant
Brevundimonas
species. |
| doi_str_mv | 10.1007/s10096-011-1210-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_890032826</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2451134521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-a2d30e2300a4466a19c5191bfa44f0ca8b5a832e8f746aa21b6c820f8c6be30d3</originalsourceid><addsrcrecordid>eNp1kM9qFTEUh4NY2mvtA7iRIBQ3HXtOkplJlm3RWii4aZcSzmQymjJ_rsmM0l3foW_YJzGXe7UguElI8v3OOfkYe4PwAQHq05RXUxWAWKBAKMoXbIVKloWStXzJVmCkKkwt5AF7ldId5Iyu6312IFBVqJVZsa_n5GYf_RCIO1qSb3lzz8-j_7mMbRimkRJPa--CT5xmTjzDc6B4n-no-fcprcNMPQ8jv6Hwi8YTLnKfp4dHAQiv2V5HffJHu_2Q3X76eHPxubj-cnl1cXZdOFVVc0GileCFBCCVLwiNK9Fg0-VjB450U5KWwuuuVhWRwKZyWkCnXdV4Ca08ZO-3dddx-rH4NNshJOf7nkY_LclqAyCFFlUm3_1D3k1LHPNwVmuDGtFsINxCLk4pRd_ZdQxD_rRFsBvzdmveZvN2Y96WOfN2V3hpBt_-TfxRnYHjHUDJUd9FGl1Iz5wqa9A1ZE5suZSfxm8-Pk_4_-6_AbFBmX4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>889181196</pqid></control><display><type>article</type><title>Bacteremia caused by Brevundimonas species at a tertiary care hospital in Taiwan, 2000–2010</title><source>MEDLINE</source><source>Springer Journals</source><creator>Lee, M. R. ; Huang, Y. T. ; Liao, C. H. ; Chuang, T. Y. ; Lin, C. K. ; Lee, S. W. ; Lai, C. C. ; Yu, C. J. ; Hsueh, P. R.</creator><creatorcontrib>Lee, M. R. ; Huang, Y. T. ; Liao, C. H. ; Chuang, T. Y. ; Lin, C. K. ; Lee, S. W. ; Lai, C. C. ; Yu, C. J. ; Hsueh, P. R.</creatorcontrib><description>We investigated clinical and microbiological characteristics of 30 patients with
Brevundimonas
bacteremia treated at a tertiary care hospital in Taiwan during 2000–2010. All the 30 bacteria isolates were confirmed to the species level by 16S rRNA sequencing analysis. Minimum inhibitory concentrations (MICs) of 11 antimicrobial agents against these isolates were determined by the agar dilution method. Seventeen (57%) patients had underlying malignancy, 12 (40%) had undergone central catheter placement, and 13 (43%) had received chemotherapy within the previous three months. Eight (27%) patients had community-acquired bacteremia and the remaining 22 patients (73%) had healthcare-associated bacteremia. The overall 14-day and 30-day mortality rates were 13% and 17%, respectively. Among the 30 isolates,
B. vesicularis
constituted most commonly (
n
= 22, 63%), followed by
B. nasdae
(
n
= 5) and
B. diminuta
(
n
= 3). All isolates were susceptible to piperacillin-tazobactam and amikacin, while all were resistant to ciprofloxacin and colistin. Tigecycline (MICs at which 90% of isolates are inhibited [MIC
90
] was 0.12 mg/L) and doripenem (MIC
90
of 1 mg/L) both possessed good in vitro activities. In conclusions,
Brevundimonas
should be considered a pathogen that can cause bacteremia in immunocompromised hosts. Piperacillin-tazobactam, amikacin, doripenem, and tigecycline exhibit good in vitro activities against these ciprofloxacin- and colistin-resistant
Brevundimonas
species.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-011-1210-5</identifier><identifier>PMID: 21461849</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - pharmacology ; Antimicrobial agents ; Automation ; Bacteremia - epidemiology ; Bacteremia - microbiology ; Bacteremia - mortality ; Bacteremia - pathology ; Bacterial diseases ; Bacterial sepsis ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Caulobacteraceae - genetics ; Caulobacteraceae - isolation & purification ; Chemotherapy ; Child ; Child, Preschool ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - microbiology ; Community-Acquired Infections - mortality ; Community-Acquired Infections - pathology ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Cross Infection - mortality ; Cross Infection - pathology ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; DNA, Ribosomal - chemistry ; DNA, Ribosomal - genetics ; Female ; Gram-Negative Bacterial Infections - epidemiology ; Gram-Negative Bacterial Infections - microbiology ; Gram-Negative Bacterial Infections - mortality ; Gram-Negative Bacterial Infections - pathology ; Hospitals ; Human bacterial diseases ; Humans ; Identification ; Infant ; Infectious diseases ; Internal Medicine ; Laboratories ; Male ; Medical instruments ; Medical Microbiology ; Medical sciences ; Medicine ; Methods ; Microbial Sensitivity Tests ; Microbiology ; Middle Aged ; Mortality ; RNA, Ribosomal, 16S - genetics ; Sequence Analysis, DNA ; Survival Analysis ; Taiwan - epidemiology ; Young Adult</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2011-10, Vol.30 (10), p.1185-1191</ispartof><rights>Springer-Verlag 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-a2d30e2300a4466a19c5191bfa44f0ca8b5a832e8f746aa21b6c820f8c6be30d3</citedby><cites>FETCH-LOGICAL-c466t-a2d30e2300a4466a19c5191bfa44f0ca8b5a832e8f746aa21b6c820f8c6be30d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-011-1210-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-011-1210-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24570870$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21461849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, M. R.</creatorcontrib><creatorcontrib>Huang, Y. T.</creatorcontrib><creatorcontrib>Liao, C. H.</creatorcontrib><creatorcontrib>Chuang, T. Y.</creatorcontrib><creatorcontrib>Lin, C. K.</creatorcontrib><creatorcontrib>Lee, S. W.</creatorcontrib><creatorcontrib>Lai, C. C.</creatorcontrib><creatorcontrib>Yu, C. J.</creatorcontrib><creatorcontrib>Hsueh, P. R.</creatorcontrib><title>Bacteremia caused by Brevundimonas species at a tertiary care hospital in Taiwan, 2000–2010</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>We investigated clinical and microbiological characteristics of 30 patients with
Brevundimonas
bacteremia treated at a tertiary care hospital in Taiwan during 2000–2010. All the 30 bacteria isolates were confirmed to the species level by 16S rRNA sequencing analysis. Minimum inhibitory concentrations (MICs) of 11 antimicrobial agents against these isolates were determined by the agar dilution method. Seventeen (57%) patients had underlying malignancy, 12 (40%) had undergone central catheter placement, and 13 (43%) had received chemotherapy within the previous three months. Eight (27%) patients had community-acquired bacteremia and the remaining 22 patients (73%) had healthcare-associated bacteremia. The overall 14-day and 30-day mortality rates were 13% and 17%, respectively. Among the 30 isolates,
B. vesicularis
constituted most commonly (
n
= 22, 63%), followed by
B. nasdae
(
n
= 5) and
B. diminuta
(
n
= 3). All isolates were susceptible to piperacillin-tazobactam and amikacin, while all were resistant to ciprofloxacin and colistin. Tigecycline (MICs at which 90% of isolates are inhibited [MIC
90
] was 0.12 mg/L) and doripenem (MIC
90
of 1 mg/L) both possessed good in vitro activities. In conclusions,
Brevundimonas
should be considered a pathogen that can cause bacteremia in immunocompromised hosts. Piperacillin-tazobactam, amikacin, doripenem, and tigecycline exhibit good in vitro activities against these ciprofloxacin- and colistin-resistant
Brevundimonas
species.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antimicrobial agents</subject><subject>Automation</subject><subject>Bacteremia - epidemiology</subject><subject>Bacteremia - microbiology</subject><subject>Bacteremia - mortality</subject><subject>Bacteremia - pathology</subject><subject>Bacterial diseases</subject><subject>Bacterial sepsis</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Caulobacteraceae - genetics</subject><subject>Caulobacteraceae - isolation & purification</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Community-Acquired Infections - microbiology</subject><subject>Community-Acquired Infections - mortality</subject><subject>Community-Acquired Infections - pathology</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - microbiology</subject><subject>Cross Infection - mortality</subject><subject>Cross Infection - pathology</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>DNA, Ribosomal - chemistry</subject><subject>DNA, Ribosomal - genetics</subject><subject>Female</subject><subject>Gram-Negative Bacterial Infections - epidemiology</subject><subject>Gram-Negative Bacterial Infections - microbiology</subject><subject>Gram-Negative Bacterial Infections - mortality</subject><subject>Gram-Negative Bacterial Infections - pathology</subject><subject>Hospitals</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Identification</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical instruments</subject><subject>Medical Microbiology</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Methods</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Survival Analysis</subject><subject>Taiwan - epidemiology</subject><subject>Young Adult</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kM9qFTEUh4NY2mvtA7iRIBQ3HXtOkplJlm3RWii4aZcSzmQymjJ_rsmM0l3foW_YJzGXe7UguElI8v3OOfkYe4PwAQHq05RXUxWAWKBAKMoXbIVKloWStXzJVmCkKkwt5AF7ldId5Iyu6312IFBVqJVZsa_n5GYf_RCIO1qSb3lzz8-j_7mMbRimkRJPa--CT5xmTjzDc6B4n-no-fcprcNMPQ8jv6Hwi8YTLnKfp4dHAQiv2V5HffJHu_2Q3X76eHPxubj-cnl1cXZdOFVVc0GileCFBCCVLwiNK9Fg0-VjB450U5KWwuuuVhWRwKZyWkCnXdV4Ca08ZO-3dddx-rH4NNshJOf7nkY_LclqAyCFFlUm3_1D3k1LHPNwVmuDGtFsINxCLk4pRd_ZdQxD_rRFsBvzdmveZvN2Y96WOfN2V3hpBt_-TfxRnYHjHUDJUd9FGl1Iz5wqa9A1ZE5suZSfxm8-Pk_4_-6_AbFBmX4</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Lee, M. R.</creator><creator>Huang, Y. T.</creator><creator>Liao, C. H.</creator><creator>Chuang, T. Y.</creator><creator>Lin, C. K.</creator><creator>Lee, S. W.</creator><creator>Lai, C. C.</creator><creator>Yu, C. J.</creator><creator>Hsueh, P. R.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Bacteremia caused by Brevundimonas species at a tertiary care hospital in Taiwan, 2000–2010</title><author>Lee, M. R. ; Huang, Y. T. ; Liao, C. H. ; Chuang, T. Y. ; Lin, C. K. ; Lee, S. W. ; Lai, C. C. ; Yu, C. J. ; Hsueh, P. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-a2d30e2300a4466a19c5191bfa44f0ca8b5a832e8f746aa21b6c820f8c6be30d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antimicrobial agents</topic><topic>Automation</topic><topic>Bacteremia - epidemiology</topic><topic>Bacteremia - microbiology</topic><topic>Bacteremia - mortality</topic><topic>Bacteremia - pathology</topic><topic>Bacterial diseases</topic><topic>Bacterial sepsis</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Caulobacteraceae - genetics</topic><topic>Caulobacteraceae - isolation & purification</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Community-Acquired Infections - epidemiology</topic><topic>Community-Acquired Infections - microbiology</topic><topic>Community-Acquired Infections - mortality</topic><topic>Community-Acquired Infections - pathology</topic><topic>Cross Infection - epidemiology</topic><topic>Cross Infection - microbiology</topic><topic>Cross Infection - mortality</topic><topic>Cross Infection - pathology</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>DNA, Ribosomal - chemistry</topic><topic>DNA, Ribosomal - genetics</topic><topic>Female</topic><topic>Gram-Negative Bacterial Infections - epidemiology</topic><topic>Gram-Negative Bacterial Infections - microbiology</topic><topic>Gram-Negative Bacterial Infections - mortality</topic><topic>Gram-Negative Bacterial Infections - pathology</topic><topic>Hospitals</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Identification</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Internal Medicine</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medical instruments</topic><topic>Medical Microbiology</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Methods</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Survival Analysis</topic><topic>Taiwan - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, M. R.</creatorcontrib><creatorcontrib>Huang, Y. T.</creatorcontrib><creatorcontrib>Liao, C. H.</creatorcontrib><creatorcontrib>Chuang, T. Y.</creatorcontrib><creatorcontrib>Lin, C. K.</creatorcontrib><creatorcontrib>Lee, S. W.</creatorcontrib><creatorcontrib>Lai, C. C.</creatorcontrib><creatorcontrib>Yu, C. J.</creatorcontrib><creatorcontrib>Hsueh, P. R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, M. R.</au><au>Huang, Y. T.</au><au>Liao, C. H.</au><au>Chuang, T. Y.</au><au>Lin, C. K.</au><au>Lee, S. W.</au><au>Lai, C. C.</au><au>Yu, C. J.</au><au>Hsueh, P. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacteremia caused by Brevundimonas species at a tertiary care hospital in Taiwan, 2000–2010</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>30</volume><issue>10</issue><spage>1185</spage><epage>1191</epage><pages>1185-1191</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>We investigated clinical and microbiological characteristics of 30 patients with
Brevundimonas
bacteremia treated at a tertiary care hospital in Taiwan during 2000–2010. All the 30 bacteria isolates were confirmed to the species level by 16S rRNA sequencing analysis. Minimum inhibitory concentrations (MICs) of 11 antimicrobial agents against these isolates were determined by the agar dilution method. Seventeen (57%) patients had underlying malignancy, 12 (40%) had undergone central catheter placement, and 13 (43%) had received chemotherapy within the previous three months. Eight (27%) patients had community-acquired bacteremia and the remaining 22 patients (73%) had healthcare-associated bacteremia. The overall 14-day and 30-day mortality rates were 13% and 17%, respectively. Among the 30 isolates,
B. vesicularis
constituted most commonly (
n
= 22, 63%), followed by
B. nasdae
(
n
= 5) and
B. diminuta
(
n
= 3). All isolates were susceptible to piperacillin-tazobactam and amikacin, while all were resistant to ciprofloxacin and colistin. Tigecycline (MICs at which 90% of isolates are inhibited [MIC
90
] was 0.12 mg/L) and doripenem (MIC
90
of 1 mg/L) both possessed good in vitro activities. In conclusions,
Brevundimonas
should be considered a pathogen that can cause bacteremia in immunocompromised hosts. Piperacillin-tazobactam, amikacin, doripenem, and tigecycline exhibit good in vitro activities against these ciprofloxacin- and colistin-resistant
Brevundimonas
species.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21461849</pmid><doi>10.1007/s10096-011-1210-5</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2011-10, Vol.30 (10), p.1185-1191 |
| issn | 0934-9723 1435-4373 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_890032826 |
| source | MEDLINE; Springer Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology Antimicrobial agents Automation Bacteremia - epidemiology Bacteremia - microbiology Bacteremia - mortality Bacteremia - pathology Bacterial diseases Bacterial sepsis Biological and medical sciences Biomedical and Life Sciences Biomedicine Caulobacteraceae - genetics Caulobacteraceae - isolation & purification Chemotherapy Child Child, Preschool Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Community-Acquired Infections - mortality Community-Acquired Infections - pathology Cross Infection - epidemiology Cross Infection - microbiology Cross Infection - mortality Cross Infection - pathology DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Ribosomal - chemistry DNA, Ribosomal - genetics Female Gram-Negative Bacterial Infections - epidemiology Gram-Negative Bacterial Infections - microbiology Gram-Negative Bacterial Infections - mortality Gram-Negative Bacterial Infections - pathology Hospitals Human bacterial diseases Humans Identification Infant Infectious diseases Internal Medicine Laboratories Male Medical instruments Medical Microbiology Medical sciences Medicine Methods Microbial Sensitivity Tests Microbiology Middle Aged Mortality RNA, Ribosomal, 16S - genetics Sequence Analysis, DNA Survival Analysis Taiwan - epidemiology Young Adult |
| title | Bacteremia caused by Brevundimonas species at a tertiary care hospital in Taiwan, 2000–2010 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T17%3A42%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bacteremia%20caused%20by%20Brevundimonas%20species%20at%20a%20tertiary%20care%20hospital%20in%20Taiwan,%202000%E2%80%932010&rft.jtitle=European%20journal%20of%20clinical%20microbiology%20&%20infectious%20diseases&rft.au=Lee,%20M.%20R.&rft.date=2011-10-01&rft.volume=30&rft.issue=10&rft.spage=1185&rft.epage=1191&rft.pages=1185-1191&rft.issn=0934-9723&rft.eissn=1435-4373&rft_id=info:doi/10.1007/s10096-011-1210-5&rft_dat=%3Cproquest_cross%3E2451134521%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=889181196&rft_id=info:pmid/21461849&rfr_iscdi=true |