Collagen IV‐derived peptide binds hydrophobic cavity of Legionella pneumophila Mip and interferes with bacterial epithelial transmigration

Summary The Legionella virulence factor Mip (macrophage infectivity potentiator) contributes to bacterial dissemination within infected lung tissue. The Mip protein, which belongs to the enzyme family of FK506‐binding proteins (FKBP), binds specifically to collagen IV. We identified a surface‐expose...

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Veröffentlicht in:	Cellular microbiology 2011-10, Vol.13 (10), p.1558-1572
Hauptverfasser:	Ünal, Can, Schwedhelm, Kai F., Thiele, Alexandra, Weiwad, Matthias, Schweimer, Kristian, Frese, Frederike, Fischer, Gunter, Hacker, Jörg, Faber, Cornelius, Steinert, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacterial Proteins - metabolism Cell Line Collagen Type IV - metabolism Epithelial Cells - microbiology Host-Pathogen Interactions Humans Immunoprecipitation Legionella pneumophila Legionella pneumophila - pathogenicity Magnetic Resonance Spectroscopy Models, Molecular Molecular Dynamics Simulation Nuclear Magnetic Resonance, Biomolecular Peptidylprolyl Isomerase - metabolism Protein Binding Protein Interaction Mapping Transendothelial and Transepithelial Migration
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