The hepatitis B e antigen suppresses IL-1β-mediated NF-κB activation in hepatocytes

Previous clinical studies have demonstrated an association between the hepatitis B e antigen and Toll‐like receptor (TLR) expression and signalling. Therefore, the aim of this study was to develop an in vitro assay to measure the effect of hepatitis B virus proteins, including the precore protein, o...

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Veröffentlicht in:	Journal of viral hepatitis 2011-10, Vol.18 (10), p.e499-e507
Hauptverfasser:	Wilson, R., Warner, N., Ryan, K., Selleck, L., Colledge, D., Rodgers, S., Li, K., Revill, P., Locarnini, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Artificial Gene Fusion Cell Line Epithelial Cells - immunology Epithelial Cells - virology Genes, Reporter hepatitis B e antigen Hepatitis B e Antigens - metabolism Hepatitis B virus Hepatitis B virus - immunology Hepatitis B virus - pathogenicity Hepatocytes - immunology Hepatocytes - virology Humans Immune Evasion interleukin-1 Interleukin-1beta - antagonists & inhibitors Luciferases - genetics Luciferases - metabolism NF-kappa B - antagonists & inhibitors NF-κB activation precore protein TIR signalling
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