Early diagnosis of recurrent diffuse large B‐cell lymphoma showing intravascular lymphoma by random skin biopsy
A 66‐year‐old man was admitted to our hospital presenting 2 weeks’ history of fever of unknown origin with elevated levels of lactate dehydrogenase and C‐reactive protein. Six years before this episode, he had developed diffuse large B‐cell lymphoma, which had been successfully treated with chemorad...
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| Veröffentlicht in: | Journal of dermatology 2011-06, Vol.38 (6), p.571-574 |
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| creator | KASUYA, Akira HASHIZUME, Hideo TAKIGAWA, Masahiro |
| description | A 66‐year‐old man was admitted to our hospital presenting 2 weeks’ history of fever of unknown origin with elevated levels of lactate dehydrogenase and C‐reactive protein. Six years before this episode, he had developed diffuse large B‐cell lymphoma, which had been successfully treated with chemoradiation. While recurrence of diffuse large B‐cell lymphoma was suspected, there was neither lymphadenopathy nor tumor formation by the imaging study. Random biopsy from normal‐appearing abdominal skin showed extensive infiltration of CD20+, CD79a+, CD3− atypical lymphoid cells in the lumen of vessels in subcutaneous tissues. These findings led us to the diagnosis of intravascular B‐cell lymphoma. Following rituximab plus cyclophosphamide, adriamycin, vincristine and prednisolone therapy, high fever subsided, and lactate dehydrogenase and C‐reactive protein levels returned to the normal range. In conclusion, random skin biopsy is useful for the early diagnosis of intravascular B‐cell lymphoma. |
| doi_str_mv | 10.1111/j.1346-8138.2010.01127.x |
| format | Article |
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Six years before this episode, he had developed diffuse large B‐cell lymphoma, which had been successfully treated with chemoradiation. While recurrence of diffuse large B‐cell lymphoma was suspected, there was neither lymphadenopathy nor tumor formation by the imaging study. Random biopsy from normal‐appearing abdominal skin showed extensive infiltration of CD20+, CD79a+, CD3− atypical lymphoid cells in the lumen of vessels in subcutaneous tissues. These findings led us to the diagnosis of intravascular B‐cell lymphoma. Following rituximab plus cyclophosphamide, adriamycin, vincristine and prednisolone therapy, high fever subsided, and lactate dehydrogenase and C‐reactive protein levels returned to the normal range. 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Six years before this episode, he had developed diffuse large B‐cell lymphoma, which had been successfully treated with chemoradiation. While recurrence of diffuse large B‐cell lymphoma was suspected, there was neither lymphadenopathy nor tumor formation by the imaging study. Random biopsy from normal‐appearing abdominal skin showed extensive infiltration of CD20+, CD79a+, CD3− atypical lymphoid cells in the lumen of vessels in subcutaneous tissues. These findings led us to the diagnosis of intravascular B‐cell lymphoma. Following rituximab plus cyclophosphamide, adriamycin, vincristine and prednisolone therapy, high fever subsided, and lactate dehydrogenase and C‐reactive protein levels returned to the normal range. In conclusion, random skin biopsy is useful for the early diagnosis of intravascular B‐cell lymphoma.</description><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols</subject><subject>Biopsy</subject><subject>Blood Vessels - pathology</subject><subject>fever of unknown origin</subject><subject>Humans</subject><subject>intravascular B‐cell lymphoma</subject><subject>Lymphoma, Large B-Cell, Diffuse - diagnosis</subject><subject>Lymphoma, Large B-Cell, Diffuse - drug therapy</subject><subject>Male</subject><subject>Neoplasm Recurrence, Local - blood supply</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Neoplasm Recurrence, Local - drug therapy</subject><subject>random skin biopsy</subject><subject>recurrent diffuse large B‐cell lymphoma</subject><subject>Skin - blood supply</subject><subject>Skin - pathology</subject><subject>Skin Neoplasms - blood supply</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Time Factors</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1OwzAQhS0EoqVwBeQdqxQ7dhJ7wQJK-VMlNrC2HNtpXfJXu6HNjiNwRk5CQqHMZkbzPo1G7wEAMRrjri6XY0xoHDBM2DhE3RZhHCbj7QEY7oVDMESERUFIUTIAJ94vEQp5hNExGISYY4qjaAhWU-nyFmor52XlrYdVBp1RjXOmXHfrLGu8gbl0cwNvvj4-lclzmLdFvagKCf2i2thyDm25dvJdetV05L-cttDJUlcF9G-2hKmtat-egqNM5t6c_fYReL2bvkwegtnz_ePkehYoSlgShBk3XGkTJRlnJuYxixUzlGY4DWlsJMHKZFoyHmvOtEYUpZKQUHOppOQ0JSNwsbtbu2rVGL8WhfX9-7I0VeMF4wgRjBHryPNfskkLo0XtbCFdK_5c6oCrHbCxuWn3OkaiT0MsRW-66E0XfRriJw2xFU-3034i30-IgRY</recordid><startdate>201106</startdate><enddate>201106</enddate><creator>KASUYA, Akira</creator><creator>HASHIZUME, Hideo</creator><creator>TAKIGAWA, Masahiro</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201106</creationdate><title>Early diagnosis of recurrent diffuse large B‐cell lymphoma showing intravascular lymphoma by random skin biopsy</title><author>KASUYA, Akira ; HASHIZUME, Hideo ; TAKIGAWA, Masahiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4387-2f9e9cde57f98e69686c8e44f1b246ea31cefda896d98dd040ba332d9acaa94b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols</topic><topic>Biopsy</topic><topic>Blood Vessels - pathology</topic><topic>fever of unknown origin</topic><topic>Humans</topic><topic>intravascular B‐cell lymphoma</topic><topic>Lymphoma, Large B-Cell, Diffuse - diagnosis</topic><topic>Lymphoma, Large B-Cell, Diffuse - drug therapy</topic><topic>Male</topic><topic>Neoplasm Recurrence, Local - blood supply</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>Neoplasm Recurrence, Local - drug therapy</topic><topic>random skin biopsy</topic><topic>recurrent diffuse large B‐cell lymphoma</topic><topic>Skin - blood supply</topic><topic>Skin - pathology</topic><topic>Skin Neoplasms - blood supply</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - drug therapy</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KASUYA, Akira</creatorcontrib><creatorcontrib>HASHIZUME, Hideo</creatorcontrib><creatorcontrib>TAKIGAWA, Masahiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KASUYA, Akira</au><au>HASHIZUME, Hideo</au><au>TAKIGAWA, Masahiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early diagnosis of recurrent diffuse large B‐cell lymphoma showing intravascular lymphoma by random skin biopsy</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2011-06</date><risdate>2011</risdate><volume>38</volume><issue>6</issue><spage>571</spage><epage>574</epage><pages>571-574</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>A 66‐year‐old man was admitted to our hospital presenting 2 weeks’ history of fever of unknown origin with elevated levels of lactate dehydrogenase and C‐reactive protein. Six years before this episode, he had developed diffuse large B‐cell lymphoma, which had been successfully treated with chemoradiation. While recurrence of diffuse large B‐cell lymphoma was suspected, there was neither lymphadenopathy nor tumor formation by the imaging study. Random biopsy from normal‐appearing abdominal skin showed extensive infiltration of CD20+, CD79a+, CD3− atypical lymphoid cells in the lumen of vessels in subcutaneous tissues. These findings led us to the diagnosis of intravascular B‐cell lymphoma. Following rituximab plus cyclophosphamide, adriamycin, vincristine and prednisolone therapy, high fever subsided, and lactate dehydrogenase and C‐reactive protein levels returned to the normal range. In conclusion, random skin biopsy is useful for the early diagnosis of intravascular B‐cell lymphoma.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21914155</pmid><doi>10.1111/j.1346-8138.2010.01127.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of dermatology, 2011-06, Vol.38 (6), p.571-574 |
| issn | 0385-2407 1346-8138 |
| language | eng |
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| subjects | Aged Antineoplastic Combined Chemotherapy Protocols Biopsy Blood Vessels - pathology fever of unknown origin Humans intravascular B‐cell lymphoma Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - drug therapy Male Neoplasm Recurrence, Local - blood supply Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - drug therapy random skin biopsy recurrent diffuse large B‐cell lymphoma Skin - blood supply Skin - pathology Skin Neoplasms - blood supply Skin Neoplasms - diagnosis Skin Neoplasms - drug therapy Time Factors |
| title | Early diagnosis of recurrent diffuse large B‐cell lymphoma showing intravascular lymphoma by random skin biopsy |
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