The Fentanyl/Etomidate‐Anesthetized Beagle (FEAB) Model in Safety Pharmacology Assessment

This unit describes a procedure for performing safety studies in the anesthetized beagle dog. Detailed are the anesthetic regime, the surgical procedure, and all materials needed to perform cardiovascular, central nervous system, and respiratory safety studies in these animals. An overview of all pa...

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Veröffentlicht in:	Current Protocols in Pharmacology 2011-09, Vol.54 (1), p.10.13.1-10.13.21
Hauptverfasser:	van der Linde, Henk J., Deuren, Bruno Van, Somers, Yves, Teisman, Ard, Gallacher, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	anesthesia Anesthetics, Intravenous Animals cardiovascular CNS dog Dogs Drug Evaluation, Preclinical - methods etomidate Etomidate - pharmacology fentanyl Fentanyl - pharmacology respiratory safety pharmacology Toxicity Tests - methods
Online-Zugang:	Volltext
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