The Fentanyl/Etomidate‐Anesthetized Beagle (FEAB) Model in Safety Pharmacology Assessment
This unit describes a procedure for performing safety studies in the anesthetized beagle dog. Detailed are the anesthetic regime, the surgical procedure, and all materials needed to perform cardiovascular, central nervous system, and respiratory safety studies in these animals. An overview of all pa...
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| Veröffentlicht in: | Current Protocols in Pharmacology 2011-09, Vol.54 (1), p.10.13.1-10.13.21 |
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| container_end_page | 10.13.21 |
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| container_issue | 1 |
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| container_title | Current Protocols in Pharmacology |
| container_volume | 54 |
| creator | van der Linde, Henk J. Deuren, Bruno Van Somers, Yves Teisman, Ard Gallacher, David J. |
| description | This unit describes a procedure for performing safety studies in the anesthetized beagle dog. Detailed are the anesthetic regime, the surgical procedure, and all materials needed to perform cardiovascular, central nervous system, and respiratory safety studies in these animals. An overview of all parameters that can be measured and calculated is provided, as are experimental protocols. Endpoints discussed include hemodynamic, electrocardiological, respiratory, arterial blood, and electroencephalogical parameters. Also presented are a formula to correct QT interval for changes in core body temperature and an overview of changes in ECG, MAP, and EEG traces that may occur during safety studies. The information provided yields a multiparametric model for performing reliable safety studies in anesthetized dogs. Curr. Protoc. Pharmacol. 54:10.13.1‐10.13.21. © 2011 by John Wiley & Sons, Inc. |
| doi_str_mv | 10.1002/0471141755.ph1013s54 |
| format | Article |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | anesthesia Anesthetics, Intravenous Animals cardiovascular CNS dog Dogs Drug Evaluation, Preclinical - methods etomidate Etomidate - pharmacology fentanyl Fentanyl - pharmacology respiratory safety pharmacology Toxicity Tests - methods |
| title | The Fentanyl/Etomidate‐Anesthetized Beagle (FEAB) Model in Safety Pharmacology Assessment |
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