Role of T and Dendritic Cells in Mouse Islet Allografts Treated With Anti-CD45RB Monoclonal Antibodies
Abstract Currently lifelong immunosuppression is required for organ transplant recipients. Anti-CD45RB monoclonal antibody (mAb) prolongs graft survival by mechanisms that are not yet clear. Therefore, we investigated the role of T and dendritic cells (DC) in islet allografts treated with anti-CD45R...
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| Veröffentlicht in: | Transplantation proceedings 2011-09, Vol.43 (7), p.2721-2727 |
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| creator | Deng, C.Y Qi, H Wang, X.G Zhou, H.X Deng, S.P Li, F.R |
| description | Abstract Currently lifelong immunosuppression is required for organ transplant recipients. Anti-CD45RB monoclonal antibody (mAb) prolongs graft survival by mechanisms that are not yet clear. Therefore, we investigated the role of T and dendritic cells (DC) in islet allografts treated with anti-CD45RB mAb after transplantation of 200 allogeneic islets (BALB/c mouse) under the kidney capsules of diabetic C57BL/6 mice treated with intraperitoneal injections of 100 μg of anti-CD45RB mAb on days 0, 1, 3, 5, and 7. We observed a tilt of the ratios of Th1/Th2 and Tc1/Tc2 to Th2 and Tc2. The numbers of naïve and memory T cells were down-regulated in peripheral blood after transplantation. In addition, the maturation, endocytosis, and interleukin-12 secreted by DC derived from bone marrow cells was suppressed in recipient mice. Therefore, anti-CD45RB mAb alleviated, rejection by suppressive effects on T-lymphocyte subsets and DC. |
| doi_str_mv | 10.1016/j.transproceed.2011.05.049 |
| format | Article |
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Anti-CD45RB monoclonal antibody (mAb) prolongs graft survival by mechanisms that are not yet clear. Therefore, we investigated the role of T and dendritic cells (DC) in islet allografts treated with anti-CD45RB mAb after transplantation of 200 allogeneic islets (BALB/c mouse) under the kidney capsules of diabetic C57BL/6 mice treated with intraperitoneal injections of 100 μg of anti-CD45RB mAb on days 0, 1, 3, 5, and 7. We observed a tilt of the ratios of Th1/Th2 and Tc1/Tc2 to Th2 and Tc2. The numbers of naïve and memory T cells were down-regulated in peripheral blood after transplantation. In addition, the maturation, endocytosis, and interleukin-12 secreted by DC derived from bone marrow cells was suppressed in recipient mice. Therefore, anti-CD45RB mAb alleviated, rejection by suppressive effects on T-lymphocyte subsets and DC.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2011.05.049</identifier><identifier>PMID: 21911152</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Antibodies, Monoclonal - immunology ; Biological and medical sciences ; Dendritic Cells - immunology ; Diabetes Mellitus, Experimental - immunology ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Immunologic Memory ; Islets of Langerhans - immunology ; Leukocyte Common Antigens - immunology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Streptozocin ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; T-Lymphocytes - immunology ; Tissue, organ and graft immunology ; Transplantation, Homologous</subject><ispartof>Transplantation proceedings, 2011-09, Vol.43 (7), p.2721-2727</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-1a5aff803f7009e2e3e131086b53f5e8d18cf307832a3ef0db74ed1abb56b90a3</citedby><cites>FETCH-LOGICAL-c464t-1a5aff803f7009e2e3e131086b53f5e8d18cf307832a3ef0db74ed1abb56b90a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2011.05.049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24549857$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21911152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deng, C.Y</creatorcontrib><creatorcontrib>Qi, H</creatorcontrib><creatorcontrib>Wang, X.G</creatorcontrib><creatorcontrib>Zhou, H.X</creatorcontrib><creatorcontrib>Deng, S.P</creatorcontrib><creatorcontrib>Li, F.R</creatorcontrib><title>Role of T and Dendritic Cells in Mouse Islet Allografts Treated With Anti-CD45RB Monoclonal Antibodies</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Currently lifelong immunosuppression is required for organ transplant recipients. Anti-CD45RB monoclonal antibody (mAb) prolongs graft survival by mechanisms that are not yet clear. Therefore, we investigated the role of T and dendritic cells (DC) in islet allografts treated with anti-CD45RB mAb after transplantation of 200 allogeneic islets (BALB/c mouse) under the kidney capsules of diabetic C57BL/6 mice treated with intraperitoneal injections of 100 μg of anti-CD45RB mAb on days 0, 1, 3, 5, and 7. We observed a tilt of the ratios of Th1/Th2 and Tc1/Tc2 to Th2 and Tc2. The numbers of naïve and memory T cells were down-regulated in peripheral blood after transplantation. In addition, the maturation, endocytosis, and interleukin-12 secreted by DC derived from bone marrow cells was suppressed in recipient mice. Therefore, anti-CD45RB mAb alleviated, rejection by suppressive effects on T-lymphocyte subsets and DC.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Biological and medical sciences</subject><subject>Dendritic Cells - immunology</subject><subject>Diabetes Mellitus, Experimental - immunology</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Immunologic Memory</subject><subject>Islets of Langerhans - immunology</subject><subject>Leukocyte Common Antigens - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Streptozocin</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>T-Lymphocytes - immunology</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation, Homologous</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkluPEyEUgCdG49bVv2CIifFpRs4AM4wPJrX1sskak7XGR8IwB6VS2IWpyf57qe1G45NPBPjO7YOqega0AQrdy20zJx3ydYoGcWpaCtBQ0VA-3KsWIHtWt13L7lcLSjnUwLg4qx7lvKVl33L2sDprYQAA0S4qexU9kmjJhugwkTWGKbnZGbJC7zNxgXyM-4zkInucydL7-C1pO2eySahnnMhXN38nyzC7erXm4upN4UM0Pgbtfx-PcXKYH1cPrPYZn5zW8-rLu7eb1Yf68tP7i9Xysja843MNWmhrJWW2p3TAFhkCAyq7UTArUE4gjWW0l6zVDC2dxp7jBHocRTcOVLPz6sUxb5Fzs8c8q53LpoyiA5Y5lJQD5z0bhkK-OpImxZwTWnWd3E6nWwVUHTSrrfpbszpoVlSoorkEPz2V2Y-7cncXeue1AM9PgM5Ge1sSGZf_cFzwQYq-cOsjh0XKT4dJZeMwGJxcQjOrKbr_6-f1P2mMd8GVyj_wFvM27lN5j6xA5VZR9fnwMQ7_AoDS0oZkvwCmlrZR</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Deng, C.Y</creator><creator>Qi, H</creator><creator>Wang, X.G</creator><creator>Zhou, H.X</creator><creator>Deng, S.P</creator><creator>Li, F.R</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Role of T and Dendritic Cells in Mouse Islet Allografts Treated With Anti-CD45RB Monoclonal Antibodies</title><author>Deng, C.Y ; Qi, H ; Wang, X.G ; Zhou, H.X ; Deng, S.P ; Li, F.R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-1a5aff803f7009e2e3e131086b53f5e8d18cf307832a3ef0db74ed1abb56b90a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Biological and medical sciences</topic><topic>Dendritic Cells - immunology</topic><topic>Diabetes Mellitus, Experimental - immunology</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Immunologic Memory</topic><topic>Islets of Langerhans - immunology</topic><topic>Leukocyte Common Antigens - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Streptozocin</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>T-Lymphocytes - immunology</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deng, C.Y</creatorcontrib><creatorcontrib>Qi, H</creatorcontrib><creatorcontrib>Wang, X.G</creatorcontrib><creatorcontrib>Zhou, H.X</creatorcontrib><creatorcontrib>Deng, S.P</creatorcontrib><creatorcontrib>Li, F.R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deng, C.Y</au><au>Qi, H</au><au>Wang, X.G</au><au>Zhou, H.X</au><au>Deng, S.P</au><au>Li, F.R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of T and Dendritic Cells in Mouse Islet Allografts Treated With Anti-CD45RB Monoclonal Antibodies</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>43</volume><issue>7</issue><spage>2721</spage><epage>2727</epage><pages>2721-2727</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Currently lifelong immunosuppression is required for organ transplant recipients. Anti-CD45RB monoclonal antibody (mAb) prolongs graft survival by mechanisms that are not yet clear. Therefore, we investigated the role of T and dendritic cells (DC) in islet allografts treated with anti-CD45RB mAb after transplantation of 200 allogeneic islets (BALB/c mouse) under the kidney capsules of diabetic C57BL/6 mice treated with intraperitoneal injections of 100 μg of anti-CD45RB mAb on days 0, 1, 3, 5, and 7. We observed a tilt of the ratios of Th1/Th2 and Tc1/Tc2 to Th2 and Tc2. The numbers of naïve and memory T cells were down-regulated in peripheral blood after transplantation. In addition, the maturation, endocytosis, and interleukin-12 secreted by DC derived from bone marrow cells was suppressed in recipient mice. Therefore, anti-CD45RB mAb alleviated, rejection by suppressive effects on T-lymphocyte subsets and DC.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>21911152</pmid><doi>10.1016/j.transproceed.2011.05.049</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Antibodies, Monoclonal - immunology Biological and medical sciences Dendritic Cells - immunology Diabetes Mellitus, Experimental - immunology Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Immunologic Memory Islets of Langerhans - immunology Leukocyte Common Antigens - immunology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Streptozocin Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases T-Lymphocytes - immunology Tissue, organ and graft immunology Transplantation, Homologous |
| title | Role of T and Dendritic Cells in Mouse Islet Allografts Treated With Anti-CD45RB Monoclonal Antibodies |
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